Journal ArticleDOI
Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B.
William E. Klunk,Henry Engler,Agneta Nordberg,Yanming Wang,G. Blomqvist,Daniel P. Holt,Mats Bergström,Irina Savitcheva,Guo Feng Huang,Sergio Estrada,Birgitta Ausén,Manik L. Debnath,Julien Barletta,Julie C. Price,Johan Sandell,Brian J. Lopresti,Anders Wall,Pernilla Koivisto,Gunnar Antoni,Chester A. Mathis,Bengt Långström +20 more
TLDR
The results suggest that PET imaging with the novel tracer, PIB, can provide quantitative information on amyloid deposits in living subjects.Abstract:
This report describes the first human study of a novel amyloid-imaging positron emission tomography (PET) tracer, termed Pittsburgh Compound-B (PIB), in 16 patients with diagnosed mild AD and 9 controls. Compared with controls, AD patients typically showed marked retention of PIB in areas of association cortex known to contain large amounts of amyloid deposits in AD. In the AD patient group, PIB retention was increased most prominently in frontal cortex (1.94-fold, p = 0.0001). Large increases also were observed in parietal (1.71-fold, p = 0.0002), temporal (1.52-fold, p = 0.002), and occipital (1.54-fold, p = 0.002) cortex and the striatum (1.76-fold, p = 0.0001). PIB retention was equivalent in AD patients and controls in areas known to be relatively unaffected by amyloid deposition (such as subcortical white matter, pons, and cerebellum). Studies in three young (21 years) and six older healthy controls (69.5 +/- 11 years) showed low PIB retention in cortical areas and no significant group differences between young and older controls. In cortical areas, PIB retention correlated inversely with cerebral glucose metabolism determined with 18F-fluorodeoxyglucose. This relationship was most robust in the parietal cortex (r = -0.72; p = 0.0001). The results suggest that PET imaging with the novel tracer, PIB, can provide quantitative information on amyloid deposits in living subjects.read more
Citations
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Journal ArticleDOI
Effects of beta-amyloid accumulation on neural function during encoding across the adult lifespan.
Kristen M. Kennedy,Karen M. Rodrigue,Michael D. Devous,Andrew Hebrank,Gérard N. Bischof,Denise C. Park +5 more
TL;DR: A reduction of both activation and suppression as a function of amyloid load was found across the lifespan, even in young- and middle-aged individuals, suggesting that it is detrimental, rather than compensatory in nature.
Journal ArticleDOI
Anatomical and Functional Deficits in Patients with Amnestic Mild Cognitive Impairment
TL;DR: It is found that wide spread brain volume reduction accompanied with decreased and increased regional function in MCI, while the anatomical and functional changes were independently.
Journal ArticleDOI
PIB binding in aged primate brain: Enrichment of high-affinity sites in humans with Alzheimer's disease
TL;DR: The high-affinity binding of PIB may be selective for a pathologic, human-specific conformation of multimeric Aβ, and thus could be a useful experimental tool for clarifying the unique predisposition of humans to Alzheimer's disease.
Journal ArticleDOI
Discriminative and prognostic potential of cerebrospinal fluid phosphoTau/tau ratio and neurofilaments for frontotemporal dementia subtypes.
Yolande A.L. Pijnenburg,Nicolaas A. Verwey,Wiesje M. van der Flier,Philip Scheltens,Charlotte E. Teunissen +4 more
TL;DR: This data indicates that CSF p/t‐tau and NfL are related to ALS status in FTLD‐TDP and amyotrophic lateral sclerosis, respectively.
Journal ArticleDOI
Cerebral perfusion and glucose metabolism in Alzheimer’s disease and frontotemporal dementia: two sides of the same coin?
Sander C.J. Verfaillie,Sofie Adriaanse,Maja Binnewijzend,Marije R. Benedictus,Rik Ossenkoppele,Mike P. Wattjes,Yolande A.L. Pijnenburg,Wiesje M. van der Flier,Adriaan A. Lammertsma,Joost P.A. Kuijer,Ronald Boellaard,Philip Scheltens,Bart N.M. van Berckel,Frederik Barkhof +13 more
TL;DR: Similar patterns of hypoperfusion and hypometabolism were observed in regions typically associated with AD and FTD, suggesting that ASL-MRI provides information comparable to FDG-PET.
References
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Graphical Evaluation of Blood-to-Brain Transfer Constants from Multiple-Time Uptake Data. Generalizations:
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