Journal ArticleDOI
Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B.
William E. Klunk,Henry Engler,Agneta Nordberg,Yanming Wang,G. Blomqvist,Daniel P. Holt,Mats Bergström,Irina Savitcheva,Guo Feng Huang,Sergio Estrada,Birgitta Ausén,Manik L. Debnath,Julien Barletta,Julie C. Price,Johan Sandell,Brian J. Lopresti,Anders Wall,Pernilla Koivisto,Gunnar Antoni,Chester A. Mathis,Bengt Långström +20 more
TLDR
The results suggest that PET imaging with the novel tracer, PIB, can provide quantitative information on amyloid deposits in living subjects.Abstract:
This report describes the first human study of a novel amyloid-imaging positron emission tomography (PET) tracer, termed Pittsburgh Compound-B (PIB), in 16 patients with diagnosed mild AD and 9 controls. Compared with controls, AD patients typically showed marked retention of PIB in areas of association cortex known to contain large amounts of amyloid deposits in AD. In the AD patient group, PIB retention was increased most prominently in frontal cortex (1.94-fold, p = 0.0001). Large increases also were observed in parietal (1.71-fold, p = 0.0002), temporal (1.52-fold, p = 0.002), and occipital (1.54-fold, p = 0.002) cortex and the striatum (1.76-fold, p = 0.0001). PIB retention was equivalent in AD patients and controls in areas known to be relatively unaffected by amyloid deposition (such as subcortical white matter, pons, and cerebellum). Studies in three young (21 years) and six older healthy controls (69.5 +/- 11 years) showed low PIB retention in cortical areas and no significant group differences between young and older controls. In cortical areas, PIB retention correlated inversely with cerebral glucose metabolism determined with 18F-fluorodeoxyglucose. This relationship was most robust in the parietal cortex (r = -0.72; p = 0.0001). The results suggest that PET imaging with the novel tracer, PIB, can provide quantitative information on amyloid deposits in living subjects.read more
Citations
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Journal ArticleDOI
The diagnostic value of FDG and amyloid PET in Alzheimer’s disease—A systematic review
Louise Rice,Sotirios Bisdas +1 more
TL;DR: Both techniques have been shown to detect AD with high sensitivity and specificity compared to other neurodegenerative processes and cognitively normal age-matched individuals, but future studies with standardised, uniform thresholds and a lengthier longitudinal follow-up need to be conducted to make surer conclusions about the future role of PET in clinical practice.
Journal ArticleDOI
Near-infrared fluorescent probes for imaging of amyloid plaques in Alzheimer's disease
TL;DR: A brief overview of the state-of-the-art development of NIRF Aβ probes and their in vitro and in vivo applications with special focus on design strategies and optical, binding, and brain-kinetic properties is provided.
Journal ArticleDOI
Synthesis of carbon-11 labeled fluorinated 2-arylbenzothiazoles as novel potential PET cancer imaging agents.
Min Wang,Mingzhang Gao,Bruce H. Mock,Kathy D. Miller,George W. Sledge,Gary D. Hutchins,Qi Huang Zheng +6 more
TL;DR: Carbon-11 labeled fluorinated 2-arylbenzothiazoles may serve as novel probes for positron emission tomography to image tyrosine kinase in cancers and inspire new potential antitumor drugs.
Journal ArticleDOI
Pittsburgh compound B (11C-PIB) and fluorodeoxyglucose (18 F-FDG) PET in patients with Alzheimer disease, mild cognitive impairment, and healthy controls.
Devangere P. Devanand,Arthur Mikhno,Gregory H. Pelton,Katrina Cuasay,Gnanavalli Pradhaban,J.S. Dileep Kumar,Neil Upton,Robert Lai,Roger N. Gunn,Vincenzo Libri,Xinhua Liu,Ronald L. Van Heertum,J. John Mann,Ramin V. Parsey +13 more
TL;DR: 11C-PIB PET BPND clearly distinguished diagnostic groups and combined with 18F-FDG PET rCMRGlu, this effect was stronger.
Journal ArticleDOI
PET Approaches for Diagnosis of Dementia
TL;DR: FDG-PET findings and positive or negative amyloid deposits are important biomarkers for various neurodegenerative dementias and the use of combination PET with structural MR imaging can improve the diagnostic accuracy of dementia.
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