Journal ArticleDOI
Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B.
William E. Klunk,Henry Engler,Agneta Nordberg,Yanming Wang,G. Blomqvist,Daniel P. Holt,Mats Bergström,Irina Savitcheva,Guo Feng Huang,Sergio Estrada,Birgitta Ausén,Manik L. Debnath,Julien Barletta,Julie C. Price,Johan Sandell,Brian J. Lopresti,Anders Wall,Pernilla Koivisto,Gunnar Antoni,Chester A. Mathis,Bengt Långström +20 more
TLDR
The results suggest that PET imaging with the novel tracer, PIB, can provide quantitative information on amyloid deposits in living subjects.Abstract:
This report describes the first human study of a novel amyloid-imaging positron emission tomography (PET) tracer, termed Pittsburgh Compound-B (PIB), in 16 patients with diagnosed mild AD and 9 controls. Compared with controls, AD patients typically showed marked retention of PIB in areas of association cortex known to contain large amounts of amyloid deposits in AD. In the AD patient group, PIB retention was increased most prominently in frontal cortex (1.94-fold, p = 0.0001). Large increases also were observed in parietal (1.71-fold, p = 0.0002), temporal (1.52-fold, p = 0.002), and occipital (1.54-fold, p = 0.002) cortex and the striatum (1.76-fold, p = 0.0001). PIB retention was equivalent in AD patients and controls in areas known to be relatively unaffected by amyloid deposition (such as subcortical white matter, pons, and cerebellum). Studies in three young (21 years) and six older healthy controls (69.5 +/- 11 years) showed low PIB retention in cortical areas and no significant group differences between young and older controls. In cortical areas, PIB retention correlated inversely with cerebral glucose metabolism determined with 18F-fluorodeoxyglucose. This relationship was most robust in the parietal cortex (r = -0.72; p = 0.0001). The results suggest that PET imaging with the novel tracer, PIB, can provide quantitative information on amyloid deposits in living subjects.read more
Citations
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Journal ArticleDOI
Human apoE Isoforms Differentially Regulate Brain Amyloid-β Peptide Clearance
Joseph M. Castellano,Jungsu Kim,Floy R. Stewart,Hong Jiang,Ronald B. DeMattos,Bruce W. Patterson,Anne M. Fagan,John C. Morris,Kwasi G. Mawuenyega,Carlos Cruchaga,Alison Goate,Kelly R. Bales,Steven M. Paul,Randall J. Bateman,David M. Holtzman +14 more
TL;DR: New light is shed on how apoE4 is implicated in AD and the Aβ clearance pathway is highlighted as a new target for developing drugs to slow or even halt the accumulation of amyloid plaques in patients with AD.
Journal ArticleDOI
Imaging beta-amyloid burden in aging and dementia.
Christopher C. Rowe,Steven Ng,Uwe Ackermann,Sylvia J. Gong,Kerryn E. Pike,Gregory Raymond Savage,Tiffany F. Cowie,Kerryn L Dickinson,Paul Maruff,David Darby,Clare Smith,Michael Woodward,John Merory,Henri Tochon-Danguy,Graeme O'Keefe,William E. Klunk,Chett A Mathis,Julie C. Price,Colin L. Masters,Colin L. Masters,Victor L. Villemagne,Victor L. Villemagne +21 more
TL;DR: Pittsburgh Compound B PET findings match histopathologic reports of β-amyloid (Aβ) distribution in aging and dementia, and suggest that Aβ may influence the development of dementia with Lewy bodies, and therefore strategies to reduce A β may benefit this condition.
Journal ArticleDOI
Ways toward an early diagnosis in Alzheimer’s disease: The Alzheimer’s Disease Neuroimaging Initiative (ADNI)
Susanne G. Mueller,Susanne G. Mueller,Michael W. Weiner,Michael W. Weiner,Leon J. Thal,Ronald C. Petersen,Clifford R. Jack,William J. Jagust,John Q. Trojanowski,Arthur W. Toga,Laurel A. Beckett +10 more
TL;DR: There is increasing evidence that a combination of currently existing neuroimaging and cerebrospinal fluid (CSF) and blood biomarkers can provide important complementary information and thus contribute to a more accurate and earlier diagnosis of AD.
Journal ArticleDOI
Selective changes of resting-state networks in individuals at risk for Alzheimer's disease
Christian Sorg,Valentin Riedl,Valentin Riedl,Mark Mühlau,Vince D. Calhoun,Tom Eichele,Leonhard Läer,Alexander Drzezga,Hans Förstl,Alexander Kurz,Claus Zimmer,Afra M. Wohlschläger +11 more
TL;DR: This work analyzes functional and structural MRI data from healthy elderly and patients with amnestic mild cognitive impairment and concludes that in individuals at risk for AD, a specific subset of RSNs is altered, likely representing effects of ongoing early neurodegeneration.
Journal ArticleDOI
Frequent Amyloid Deposition Without Significant Cognitive Impairment Among the Elderly
Howard J. Aizenstein,Robert D. Nebes,Judith Saxton,Julie C. Price,Chester A. Mathis,Nicholas D. Tsopelas,Scott K. Ziolko,Jeffrey A. James,Beth E. Snitz,Patricia R. Houck,Wenzhu Bi,Ann D. Cohen,Brian J. Lopresti,Steven T. DeKosky,Edythe M. Halligan,William E. Klunk +15 more
TL;DR: In this group of participants without clinically significant impairment, amyloid deposition was not associated with worse cognitive function, suggesting that an elderly person with a significantAmyloid burden can remain cognitively normal, but this finding is based on relatively small numbers and needs to be replicated in larger cohorts.
References
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