Journal ArticleDOI
Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B.
William E. Klunk,Henry Engler,Agneta Nordberg,Yanming Wang,G. Blomqvist,Daniel P. Holt,Mats Bergström,Irina Savitcheva,Guo Feng Huang,Sergio Estrada,Birgitta Ausén,Manik L. Debnath,Julien Barletta,Julie C. Price,Johan Sandell,Brian J. Lopresti,Anders Wall,Pernilla Koivisto,Gunnar Antoni,Chester A. Mathis,Bengt Långström +20 more
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TLDR
The results suggest that PET imaging with the novel tracer, PIB, can provide quantitative information on amyloid deposits in living subjects.Abstract:
This report describes the first human study of a novel amyloid-imaging positron emission tomography (PET) tracer, termed Pittsburgh Compound-B (PIB), in 16 patients with diagnosed mild AD and 9 controls. Compared with controls, AD patients typically showed marked retention of PIB in areas of association cortex known to contain large amounts of amyloid deposits in AD. In the AD patient group, PIB retention was increased most prominently in frontal cortex (1.94-fold, p = 0.0001). Large increases also were observed in parietal (1.71-fold, p = 0.0002), temporal (1.52-fold, p = 0.002), and occipital (1.54-fold, p = 0.002) cortex and the striatum (1.76-fold, p = 0.0001). PIB retention was equivalent in AD patients and controls in areas known to be relatively unaffected by amyloid deposition (such as subcortical white matter, pons, and cerebellum). Studies in three young (21 years) and six older healthy controls (69.5 +/- 11 years) showed low PIB retention in cortical areas and no significant group differences between young and older controls. In cortical areas, PIB retention correlated inversely with cerebral glucose metabolism determined with 18F-fluorodeoxyglucose. This relationship was most robust in the parietal cortex (r = -0.72; p = 0.0001). The results suggest that PET imaging with the novel tracer, PIB, can provide quantitative information on amyloid deposits in living subjects.read more
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Journal ArticleDOI
Radioiodinated Flavones for in Vivo Imaging of β-Amyloid Plaques in the Brain
Masahiro Ono,Naoko Yoshida,Kenichi Ishibashi,Mamoru Haratake,Yasushi Arano,Hiroshi Mori,Morio Nakayama +6 more
TL;DR: The results in the study suggest that these classes of radioiodinated flavones may be useful candidates as potential imaging agents for in vivo imaging of β-amyloid peptide aggregates in the brain.
Journal ArticleDOI
Detection of amyloid in Alzheimer's disease with positron emission tomography using [11C]AZD2184.
Svante Nyberg,Maria Eriksdotter Jönhagen,Zsolt Cselényi,Christer Halldin,Per Julin,Hans Olsson,Yvonne Freund-Levi,Jan Andersson,Katarina Varnäs,Samuel P.S. Svensson,Lars Farde,Lars Farde +11 more
TL;DR: [11C]AZD2184 is a promising radioligand for detailed mapping of Aβ amyloid depositions in Alzheimer’s disease, due to low non-specific binding, high signal to background ratio and reversible binding as evident from early peak equilibrium.
Journal ArticleDOI
Disconnection of frontal and parietal areas contributes to impaired attention in very early Alzheimer's disease.
Susanne Neufang,Atae Akhrif,Valentin Riedl,Hans Förstl,Alexander Kurz,Claus Zimmer,Christian Sorg,Afra M. Wohlschläger +7 more
TL;DR: It is concluded that, at very early stages of AD, the reduction of effective connectivity in fronto-parietal circuits is related to regional gray matter volume and contributes to impairments in top-down attentional control.
Journal ArticleDOI
Evaluating atypical dementia syndromes using positron emission tomography with carbon 11 labeled Pittsburgh Compound B.
TL;DR: Pittsburgh Compound B has the potential to facilitate differential diagnosis of dementia and identify patients who could benefit from specific therapeutic strategies aimed at beta amyloid reduction.
Journal ArticleDOI
PET/CT in diagnosis of dementia
TL;DR: PET imaging with different tracers offers reliable biomarkers in dementia, which can assist clinicians in the diagnosis of different dementing disorders, especially in the situation of overlapping phenotypes.
References
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Graphical Evaluation of Blood-to-Brain Transfer Constants from Multiple-Time Uptake Data. Generalizations:
TL;DR: General equations are derived that can be used to analyze tissue uptake data when the blood–plasma concentration of the test substance cannot be easily measured and for situations when trapping of theTest substance is incomplete and for a combination of these two conditions.
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