Journal ArticleDOI
Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B.
William E. Klunk,Henry Engler,Agneta Nordberg,Yanming Wang,G. Blomqvist,Daniel P. Holt,Mats Bergström,Irina Savitcheva,Guo Feng Huang,Sergio Estrada,Birgitta Ausén,Manik L. Debnath,Julien Barletta,Julie C. Price,Johan Sandell,Brian J. Lopresti,Anders Wall,Pernilla Koivisto,Gunnar Antoni,Chester A. Mathis,Bengt Långström +20 more
Reads0
Chats0
TLDR
The results suggest that PET imaging with the novel tracer, PIB, can provide quantitative information on amyloid deposits in living subjects.Abstract:
This report describes the first human study of a novel amyloid-imaging positron emission tomography (PET) tracer, termed Pittsburgh Compound-B (PIB), in 16 patients with diagnosed mild AD and 9 controls. Compared with controls, AD patients typically showed marked retention of PIB in areas of association cortex known to contain large amounts of amyloid deposits in AD. In the AD patient group, PIB retention was increased most prominently in frontal cortex (1.94-fold, p = 0.0001). Large increases also were observed in parietal (1.71-fold, p = 0.0002), temporal (1.52-fold, p = 0.002), and occipital (1.54-fold, p = 0.002) cortex and the striatum (1.76-fold, p = 0.0001). PIB retention was equivalent in AD patients and controls in areas known to be relatively unaffected by amyloid deposition (such as subcortical white matter, pons, and cerebellum). Studies in three young (21 years) and six older healthy controls (69.5 +/- 11 years) showed low PIB retention in cortical areas and no significant group differences between young and older controls. In cortical areas, PIB retention correlated inversely with cerebral glucose metabolism determined with 18F-fluorodeoxyglucose. This relationship was most robust in the parietal cortex (r = -0.72; p = 0.0001). The results suggest that PET imaging with the novel tracer, PIB, can provide quantitative information on amyloid deposits in living subjects.read more
Citations
More filters
Journal ArticleDOI
Preclinical Alzheimer disease and risk of falls.
Susan Stark,Catherine M. Roe,Elizabeth A. Grant,Holly Hollingsworth,Tammie L.S. Benzinger,Anne M. Fagan,Virginia Buckles,John C. Morris +7 more
TL;DR: This study suggests that subtle noncognitive changes that predispose older adults to falls are associated with AD and may precede detectable cognitive changes.
Journal ArticleDOI
Imaging technology for neurodegenerative diseases: progress toward detection of specific pathologies.
TL;DR: Recent advances in imaging beta-amyloid plaques, one of the hallmarks of Alzheimer disease, offer the possibility for more efficient assessment of antiamyloid interventions as well as specific noninvasive diagnostic capabilities.
Journal ArticleDOI
Specific estrogen sulfotransferase (SULT1E1) substrates and molecular imaging probe candidates
Graham B. Cole,Gyochang Keum,Jie Liu,Gary W. Small,Nagichettiar Satyamurthy,Vladimir Kepe,Jorge R. Barrio +6 more
TL;DR: In vivo assays of SULT1E1 functional activity are now feasible in humans, as in vitro sulfation assays showed alkyl and aryl substitutions to a fused heterocyclic system modeled after β-naphthol, based on compounds that interact with the estrogen receptor.
Journal ArticleDOI
Prediction of cognitive decline by positron emission tomography of brain amyloid and tau.
Gary W. Small,Prabha Siddarth,Vladimir Kepe,Linda M. Ercoli,Alison C. Burggren,Susan Y. Bookheimer,Karen J. Miller,Jeanne Kim,Helen Lavretsky,S.C. Huang,Jorge R. Barrio +10 more
TL;DR: PET scanning may have practical utility in identifying people at risk for future cognitive decline and in tracking the effectiveness of novel interventions designed to prevent or delay neurodegeneration and cognitive decline.
Journal ArticleDOI
Comparison of Pittsburgh compound B and florbetapir in cross-sectional and longitudinal studies
Yi Su,Shaney Flores,Guoqiao Wang,Russ C. Hornbeck,Benjamin Speidel,Nelly Joseph-Mathurin,Andrei G. Vlassenko,Brian A. Gordon,Robert A. Koeppe,William E. Klunk,Clifford R. Jack,Martin R. Farlow,Stephen Salloway,Barbara J. Snider,Sarah B. Berman,Erik D. Roberson,Jared R. Brosch,Ivonne Jimenez-Velazques,Christopher H. van Dyck,Douglas Galasko,Shauna H. Yuan,Suman Jayadev,Lawrence S. Honig,Serge Gauthier,Ging-Yuek Robin Hsiung,Mario Masellis,William S. Brooks,Michael J. Fulham,Roger Clarnette,Colin L. Masters,David Wallon,Didier Hannequin,Bruno Dubois,Jérémie Pariente,Raquel Sánchez-Valle,Catherine J. Mummery,John M. Ringman,Michel Bottlaender,Gregory Klein,Smiljana Milosavljevic-Ristic,Eric McDade,Chengjie Xiong,John C. Morris,Randall J. Bateman,Tammie L.S. Benzinger +44 more
TL;DR: This study presents a direct comparison of Pittsburgh compound B–based and florbetapir‐based amyloid imaging in the same participants from two independent cohorts using a crossover design.
References
More filters
Journal ArticleDOI
Clinical diagnosis of Alzheimer's disease : report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease
Guy M. McKhann,David A. Drachman,Marshall F. Folstein,Robert Katzman,Donald L. Price,Emanuel M. Stadlan +5 more
TL;DR: The criteria proposed are intended to serve as a guide for the diagnosis of probable, possible, and definite Alzheimer's disease; these criteria will be revised as more definitive information becomes available.
Journal ArticleDOI
Neuropathological stageing of Alzheimer-related changes.
Heiko Braak,Eva Braak +1 more
TL;DR: The investigation showed that recognition of the six stages required qualitative evaluation of only a few key preparations, permitting the differentiation of six stages.
Journal ArticleDOI
Graphical Evaluation of Blood-to-Brain Transfer Constants from Multiple-Time Uptake Data:
TL;DR: A theoretical model of blood–brain exchange is developed and a procedure is derived that can be used for graphing multiple-time tissue uptake data and determining whether a unidirectional transfer process was dominant during part or all of the experimental period.
Journal ArticleDOI
Phases of Aβ-deposition in the human brain and its relevance for the development of AD
TL;DR: Aβ-deposition in the entire brain follows a distinct sequence in which the regions are hierarchically involved and expands anterogradely into regions that receive neuronal projections from regions already exhibiting Aβ.
Journal ArticleDOI
Graphical Evaluation of Blood-to-Brain Transfer Constants from Multiple-Time Uptake Data. Generalizations:
TL;DR: General equations are derived that can be used to analyze tissue uptake data when the blood–plasma concentration of the test substance cannot be easily measured and for situations when trapping of theTest substance is incomplete and for a combination of these two conditions.
Related Papers (5)
The diagnosis of dementia due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer's disease
Guy M. McKhann,Guy M. McKhann,David S. Knopman,Howard Chertkow,Bradley T. Hyman,Clifford R. Jack,Claudia H. Kawas,William E. Klunk,Walter J. Koroshetz,Jennifer J. Manly,Richard Mayeux,Richard C. Mohs,John C. Morris,Martin N. Rossor,Philip Scheltens,Maria C. Carrillo,Bill Thies,Sandra Weintraub,Creighton H. Phelps +18 more