Journal ArticleDOI
Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B.
William E. Klunk,Henry Engler,Agneta Nordberg,Yanming Wang,G. Blomqvist,Daniel P. Holt,Mats Bergström,Irina Savitcheva,Guo Feng Huang,Sergio Estrada,Birgitta Ausén,Manik L. Debnath,Julien Barletta,Julie C. Price,Johan Sandell,Brian J. Lopresti,Anders Wall,Pernilla Koivisto,Gunnar Antoni,Chester A. Mathis,Bengt Långström +20 more
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TLDR
The results suggest that PET imaging with the novel tracer, PIB, can provide quantitative information on amyloid deposits in living subjects.Abstract:
This report describes the first human study of a novel amyloid-imaging positron emission tomography (PET) tracer, termed Pittsburgh Compound-B (PIB), in 16 patients with diagnosed mild AD and 9 controls. Compared with controls, AD patients typically showed marked retention of PIB in areas of association cortex known to contain large amounts of amyloid deposits in AD. In the AD patient group, PIB retention was increased most prominently in frontal cortex (1.94-fold, p = 0.0001). Large increases also were observed in parietal (1.71-fold, p = 0.0002), temporal (1.52-fold, p = 0.002), and occipital (1.54-fold, p = 0.002) cortex and the striatum (1.76-fold, p = 0.0001). PIB retention was equivalent in AD patients and controls in areas known to be relatively unaffected by amyloid deposition (such as subcortical white matter, pons, and cerebellum). Studies in three young (21 years) and six older healthy controls (69.5 +/- 11 years) showed low PIB retention in cortical areas and no significant group differences between young and older controls. In cortical areas, PIB retention correlated inversely with cerebral glucose metabolism determined with 18F-fluorodeoxyglucose. This relationship was most robust in the parietal cortex (r = -0.72; p = 0.0001). The results suggest that PET imaging with the novel tracer, PIB, can provide quantitative information on amyloid deposits in living subjects.read more
Citations
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Journal ArticleDOI
Differential effects of the APOE genotype on brain function across the lifespan
Nicola Filippini,Klaus P. Ebmeier,Bradley J. MacIntosh,Aaron J. Trachtenberg,Giovanni B. Frisoni,Gordon K. Wilcock,Christian F. Beckmann,Christian F. Beckmann,Steve M. Smith,Paul M. Matthews,Paul M. Matthews,Clare E. Mackay +11 more
TL;DR: A significant interaction between age and ε4-status in the hippocampi, frontal pole, subcortical nuclei, middle temporal gyri and cerebellum is found, such that aging was associated with decreased activity in e4-carriers and increased activity in non-carrier.
Journal ArticleDOI
Amyloid-β Contributes to Blood–Brain Barrier Leakage in Transgenic Human Amyloid Precursor Protein Mice and in Humans With Cerebral Amyloid Angiopathy
Anika M.S. Hartz,Björn Bauer,Emma L. B. Soldner,Andrea Wolf,Sandra Boy,Roland Backhaus,Ivan Mihaljevic,Ulrich Bogdahn,Hans H. Klünemann,Gerhard Schuierer,Felix Schlachetzki +10 more
TL;DR: It is concluded that amyloid-&bgr; causes BBB leakage and that assessing BBB permeability could potentially help characterize CAA progression and be a surrogate marker for treatment response.
Journal ArticleDOI
Longitudinal stability of CSF biomarkers in Alzheimer's disease
Kaj Blennow,Henrik Zetterberg,Lennart Minthon,Lars Lannfelt,Stig Strid,Peter Annas,Hans Basun,Niels Andreasen +7 more
TL;DR: It is concluded that T-tau, P-t Tau and Abeta42 concentrations in CSF are remarkably stable over a 6-month period in individual AD patients, suggesting that these biomarkers may have a potential to identify and monitor very minor biochemical changes induced by treatment, and thus support their possible usefulness in clinical trials with drug candidates with disease-modifying potential.
Journal ArticleDOI
Imaging central nervous system myelin by positron emission tomography in multiple sclerosis using [methyl‐11C]‐2‐(4′‐methylaminophenyl)‐ 6‐hydroxybenzothiazole
Bruno Stankoff,Leorah Freeman,Leorah Freeman,Marie Stéphane Aigrot,Marie Stéphane Aigrot,Audrey Chardain,Audrey Chardain,Frédéric Dollé,Anna Williams,Damien Galanaud,Lucie Armand,Stéphane Lehéricy,Catherine Lubetzki,Bernard Zalc,Michel Bottlaender +14 more
TL;DR: It is questioned whether the thioflavine‐T derivative 2‐(4′‐methylaminophenyl)‐6‐hydroxybenzothiazole (PIB), which also binds to amyloid plaques, could serve as a myelin marker.
Journal ArticleDOI
Appropriate Use Criteria for Amyloid PET: A Report of the Amyloid Imaging Task Force, the Society of Nuclear Medicine and Molecular Imaging, and the Alzheimer’s Association
Keith A. Johnson,Satoshi Minoshima,Nicolaas I. Bohnen,Kevin J. Donohoe,Norman L. Foster,Peter Herscovitch,Jason Karlawish,Christopher C. Rowe,Maria C. Carrillo,Dean M. Hartley,Saima Hedrick,Virginia Pappas,William Thies +12 more
TL;DR: The Alzheimer's Association and the Society of Nuclear Medicine and Molecular Imaging (SNMIM) convened the Amyloid Imaging Taskforce (AIT) to provide guidance to dementia care practitioners, patients, and caregivers.
References
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Journal ArticleDOI
Clinical diagnosis of Alzheimer's disease : report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease
Guy M. McKhann,David A. Drachman,Marshall F. Folstein,Robert Katzman,Donald L. Price,Emanuel M. Stadlan +5 more
TL;DR: The criteria proposed are intended to serve as a guide for the diagnosis of probable, possible, and definite Alzheimer's disease; these criteria will be revised as more definitive information becomes available.
Journal ArticleDOI
Neuropathological stageing of Alzheimer-related changes.
Heiko Braak,Eva Braak +1 more
TL;DR: The investigation showed that recognition of the six stages required qualitative evaluation of only a few key preparations, permitting the differentiation of six stages.
Journal ArticleDOI
Graphical Evaluation of Blood-to-Brain Transfer Constants from Multiple-Time Uptake Data:
TL;DR: A theoretical model of blood–brain exchange is developed and a procedure is derived that can be used for graphing multiple-time tissue uptake data and determining whether a unidirectional transfer process was dominant during part or all of the experimental period.
Journal ArticleDOI
Phases of Aβ-deposition in the human brain and its relevance for the development of AD
TL;DR: Aβ-deposition in the entire brain follows a distinct sequence in which the regions are hierarchically involved and expands anterogradely into regions that receive neuronal projections from regions already exhibiting Aβ.
Journal ArticleDOI
Graphical Evaluation of Blood-to-Brain Transfer Constants from Multiple-Time Uptake Data. Generalizations:
TL;DR: General equations are derived that can be used to analyze tissue uptake data when the blood–plasma concentration of the test substance cannot be easily measured and for situations when trapping of theTest substance is incomplete and for a combination of these two conditions.
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