Journal ArticleDOI
Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B.
William E. Klunk,Henry Engler,Agneta Nordberg,Yanming Wang,G. Blomqvist,Daniel P. Holt,Mats Bergström,Irina Savitcheva,Guo Feng Huang,Sergio Estrada,Birgitta Ausén,Manik L. Debnath,Julien Barletta,Julie C. Price,Johan Sandell,Brian J. Lopresti,Anders Wall,Pernilla Koivisto,Gunnar Antoni,Chester A. Mathis,Bengt Långström +20 more
TLDR
The results suggest that PET imaging with the novel tracer, PIB, can provide quantitative information on amyloid deposits in living subjects.Abstract:
This report describes the first human study of a novel amyloid-imaging positron emission tomography (PET) tracer, termed Pittsburgh Compound-B (PIB), in 16 patients with diagnosed mild AD and 9 controls. Compared with controls, AD patients typically showed marked retention of PIB in areas of association cortex known to contain large amounts of amyloid deposits in AD. In the AD patient group, PIB retention was increased most prominently in frontal cortex (1.94-fold, p = 0.0001). Large increases also were observed in parietal (1.71-fold, p = 0.0002), temporal (1.52-fold, p = 0.002), and occipital (1.54-fold, p = 0.002) cortex and the striatum (1.76-fold, p = 0.0001). PIB retention was equivalent in AD patients and controls in areas known to be relatively unaffected by amyloid deposition (such as subcortical white matter, pons, and cerebellum). Studies in three young (21 years) and six older healthy controls (69.5 +/- 11 years) showed low PIB retention in cortical areas and no significant group differences between young and older controls. In cortical areas, PIB retention correlated inversely with cerebral glucose metabolism determined with 18F-fluorodeoxyglucose. This relationship was most robust in the parietal cortex (r = -0.72; p = 0.0001). The results suggest that PET imaging with the novel tracer, PIB, can provide quantitative information on amyloid deposits in living subjects.read more
Citations
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Journal ArticleDOI
Early 11C-PIB Frames and 18F-FDG PET Measures Are Comparable: A Study Validated in a Cohort of AD and FTLD Patients
TL;DR: The high correlation between pPIB and 18F-FDG measures and their comparable performance in differential diagnosis are promising in providing functional information using 11C-PIB PET data, and this approach could be useful, obviating 18F -FDG scans when longer-lived amyloid imaging agents become available.
Journal ArticleDOI
Basal forebrain atrophy correlates with amyloid β burden in Alzheimer's disease.
Georg M. Kerbler,Juergen Fripp,Christopher C. Rowe,Victor L. Villemagne,Olivier Salvado,Stephen E. Rose,Elizabeth J. Coulson +6 more
TL;DR: Cluster analysis showed that subjects with a whole basal forebrain volume below a determined cut-off value had a 7 times higher risk of having a worse diagnosis within ~18 months, and provides new evidence for a correlation between neocortical Aβ accumulation and basal fore brain degeneration.
Journal ArticleDOI
Aspects of beta-amyloid as a biomarker for Alzheimer's disease.
TL;DR: The possible biological functions of its precursor protein, the Abeta metabolism and homeostasis, the diagnostic performance of different Abeta assays in different settings and the potential usefulness of Abeta as a surrogate marker in clinical trials of novel Abeta-targeting drugs against Alzheimer's disease are reviewed.
Journal ArticleDOI
ANCA: A Family of Fluorescent Probes that Bind and Stain Amyloid Plaques in Human Tissue.
Willy M. Chang,Marianna Dakanali,Christina C. Capule,Christina J. Sigurdson,Jerry Yang,Emmanuel A. Theodorakis +5 more
TL;DR: A new family of fluorescent markers containing an Amino Naphthalenyl-2-Cyano-Acrylate motif has been synthesized and evaluated for its capability to associate with aggregated β-amyloid peptides and it was found that structural modifications of the WSG site do not affect considerably the binding affinity.
Journal ArticleDOI
Novel 18F-Labeled Benzofuran Derivatives with Improved Properties for Positron Emission Tomography (PET) Imaging of β-Amyloid Plaques in Alzheimer’s Brains
TL;DR: Two new fluorinated benzofuran derivatives are promising PET probes for imaging cerebral β-amyloid plaques in AD brain, with high affinity for Aβ(1-42) aggregates and specific labeling of β-amide plaques by 10 and 21 was observed in autoradiographs of sections of autopsied AD brain.
References
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Journal ArticleDOI
Graphical Evaluation of Blood-to-Brain Transfer Constants from Multiple-Time Uptake Data. Generalizations:
TL;DR: General equations are derived that can be used to analyze tissue uptake data when the blood–plasma concentration of the test substance cannot be easily measured and for situations when trapping of theTest substance is incomplete and for a combination of these two conditions.
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