Journal ArticleDOI
Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B.
William E. Klunk,Henry Engler,Agneta Nordberg,Yanming Wang,G. Blomqvist,Daniel P. Holt,Mats Bergström,Irina Savitcheva,Guo Feng Huang,Sergio Estrada,Birgitta Ausén,Manik L. Debnath,Julien Barletta,Julie C. Price,Johan Sandell,Brian J. Lopresti,Anders Wall,Pernilla Koivisto,Gunnar Antoni,Chester A. Mathis,Bengt Långström +20 more
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TLDR
The results suggest that PET imaging with the novel tracer, PIB, can provide quantitative information on amyloid deposits in living subjects.Abstract:
This report describes the first human study of a novel amyloid-imaging positron emission tomography (PET) tracer, termed Pittsburgh Compound-B (PIB), in 16 patients with diagnosed mild AD and 9 controls. Compared with controls, AD patients typically showed marked retention of PIB in areas of association cortex known to contain large amounts of amyloid deposits in AD. In the AD patient group, PIB retention was increased most prominently in frontal cortex (1.94-fold, p = 0.0001). Large increases also were observed in parietal (1.71-fold, p = 0.0002), temporal (1.52-fold, p = 0.002), and occipital (1.54-fold, p = 0.002) cortex and the striatum (1.76-fold, p = 0.0001). PIB retention was equivalent in AD patients and controls in areas known to be relatively unaffected by amyloid deposition (such as subcortical white matter, pons, and cerebellum). Studies in three young (21 years) and six older healthy controls (69.5 +/- 11 years) showed low PIB retention in cortical areas and no significant group differences between young and older controls. In cortical areas, PIB retention correlated inversely with cerebral glucose metabolism determined with 18F-fluorodeoxyglucose. This relationship was most robust in the parietal cortex (r = -0.72; p = 0.0001). The results suggest that PET imaging with the novel tracer, PIB, can provide quantitative information on amyloid deposits in living subjects.read more
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APOE genotype and neuroimaging markers of Alzheimer's disease: systematic review and meta-analysis
Ying Liu,Jin-Tai Yu,Hui Fu Wang,Pei Ran Han,Chen Chen Tan,Chong Wang,Xiangfei Meng,Shannon L. Risacher,Andrew J. Saykin,Lan Tan +9 more
TL;DR: APOE ɛ4 was associated with atrophic hippocampal volume in MRI markers, increased cerebral amyloid deposition and cerebral hypometabolism, which may indicate the potential role of the APOE gene in the pathophysiology of Alzheimer's disease.
Journal ArticleDOI
Positron emission tomography in CNS drug discovery and drug monitoring.
TL;DR: The basic principles of PET, the importance of appropriate tracer selection, the impact of improved radiopharmaceutical chemistry in radiotracer development, and the different roles that PET can fulfill in CNS drug research are presented.
Journal ArticleDOI
Cerebral microhemorrhage and brain β-amyloid in aging and Alzheimer disease
Paul Yates,Rojana Sirisriro,Victor Villemagne,Shawna Farquharson,C.L. Masters,Christopher C. Rowe +5 more
TL;DR: Asymptomatic Aβ deposition in older adults is strongly associated with lobar MH, and in HC, PiB+ subjects was similar, regardless of clinical classification, and there was a positive correlation between number of L MH and SUVR, and between LMH and age.
Journal ArticleDOI
Imaging in-vivo tau pathology in Alzheimer’s disease with THK5317 PET in a multimodal paradigm
Konstantinos Chiotis,Laure Saint-Aubert,Irina Savitcheva,Vesna Jelic,Pia Andersen,My Jonasson,My Jonasson,Jonas Eriksson,Jonas Eriksson,Mark Lubberink,Ove Almkvist,Ove Almkvist,Ove Almkvist,Anders Wall,Anders Wall,Gunnar Antoni,Gunnar Antoni,Agneta Nordberg,Agneta Nordberg +18 more
TL;DR: The tau-specific PET tracer [18F]THK5317 images in vivo show the expected regional distribution of tau pathology, which contrasts with the different patterns of hypometabolism and amyloid-beta deposition.
Journal ArticleDOI
Molecules that target beta-amyloid.
TL;DR: The described anti‐amyloid molecular toolbox will also provide an avenue for designing new diagnostic and therapeutic reagents that may stabilize relevant oligomeric intermediates which likely have bearing on the pathophysiology of Alzheimer’s disease.
References
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Graphical Evaluation of Blood-to-Brain Transfer Constants from Multiple-Time Uptake Data. Generalizations:
TL;DR: General equations are derived that can be used to analyze tissue uptake data when the blood–plasma concentration of the test substance cannot be easily measured and for situations when trapping of theTest substance is incomplete and for a combination of these two conditions.
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