Journal ArticleDOI
Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B.
William E. Klunk,Henry Engler,Agneta Nordberg,Yanming Wang,G. Blomqvist,Daniel P. Holt,Mats Bergström,Irina Savitcheva,Guo Feng Huang,Sergio Estrada,Birgitta Ausén,Manik L. Debnath,Julien Barletta,Julie C. Price,Johan Sandell,Brian J. Lopresti,Anders Wall,Pernilla Koivisto,Gunnar Antoni,Chester A. Mathis,Bengt Långström +20 more
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TLDR
The results suggest that PET imaging with the novel tracer, PIB, can provide quantitative information on amyloid deposits in living subjects.Abstract:
This report describes the first human study of a novel amyloid-imaging positron emission tomography (PET) tracer, termed Pittsburgh Compound-B (PIB), in 16 patients with diagnosed mild AD and 9 controls. Compared with controls, AD patients typically showed marked retention of PIB in areas of association cortex known to contain large amounts of amyloid deposits in AD. In the AD patient group, PIB retention was increased most prominently in frontal cortex (1.94-fold, p = 0.0001). Large increases also were observed in parietal (1.71-fold, p = 0.0002), temporal (1.52-fold, p = 0.002), and occipital (1.54-fold, p = 0.002) cortex and the striatum (1.76-fold, p = 0.0001). PIB retention was equivalent in AD patients and controls in areas known to be relatively unaffected by amyloid deposition (such as subcortical white matter, pons, and cerebellum). Studies in three young (21 years) and six older healthy controls (69.5 +/- 11 years) showed low PIB retention in cortical areas and no significant group differences between young and older controls. In cortical areas, PIB retention correlated inversely with cerebral glucose metabolism determined with 18F-fluorodeoxyglucose. This relationship was most robust in the parietal cortex (r = -0.72; p = 0.0001). The results suggest that PET imaging with the novel tracer, PIB, can provide quantitative information on amyloid deposits in living subjects.read more
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Journal ArticleDOI
Biomarkers for neurodegenerative diseases.
TL;DR: This review summarizes the field of biomarker research in the major neurodegenerative diseases and it is likely that more than one biomarker will be needed for early diagnosis and similarly for evaluation of disease progression for therapeutic trials.
Lifespan brain activity, b-amyloid, and Alzheimer's disease
TL;DR: In this article, a model that integrates recent cellular and molecular data with findings from the cogni- tive and imaging literature that suggest that life-long patterns of neural activity lead to Ab deposition was proposed.
Journal ArticleDOI
MRI-Based Automated Computer Classification of Probable AD Versus Normal Controls
Simon Duchesne,Anna Caroli,Cristina Geroldi,Christian Barillot,Giovanni B. Frisoni,D. L. Collins +5 more
TL;DR: It is shown in the Appendix that determinants and scaled grey-level intensity are appreciably more robust to varying parameters in validation studies using simulated data, when compared to raw intensities or grey/white matter volumes.
Journal ArticleDOI
Association of Plasma Total Tau Level With Cognitive Decline and Risk of Mild Cognitive Impairment or Dementia in the Mayo Clinic Study on Aging.
Michelle M. Mielke,Clinton E. Hagen,Alexandra M.V. Wennberg,David C. Airey,Rodolfo Savica,David S. Knopman,Mary M. Machulda,Rosebud O. Roberts,Clifford R. Jack,Ronald C. Petersen,Jeffrey L. Dage +10 more
TL;DR: Elevated plasma total tau levels are associated with cognitive decline, but the results differ based on cognitive status and the duration of follow-up, and the association between plasma totalTau levels and cognition is independent of elevated brain A&bgr;.
Journal ArticleDOI
Metabolite profiling of Alzheimer's disease cerebrospinal fluid.
Christian Czech,Peter Berndt,Kristina Busch,Oliver J. Schmitz,Jan C. Wiemer,Veronique Most,Harald Hampel,Jürgen Kastler,Hans Senn +8 more
TL;DR: Significant changes in the metabolite profile of AD patients compared to healthy controls have been identified and increased cortisol levels seemed to be related to the progression of AD and have been detected in more severe forms of AD.
References
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Guy M. McKhann,David A. Drachman,Marshall F. Folstein,Robert Katzman,Donald L. Price,Emanuel M. Stadlan +5 more
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Phases of Aβ-deposition in the human brain and its relevance for the development of AD
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Graphical Evaluation of Blood-to-Brain Transfer Constants from Multiple-Time Uptake Data. Generalizations:
TL;DR: General equations are derived that can be used to analyze tissue uptake data when the blood–plasma concentration of the test substance cannot be easily measured and for situations when trapping of theTest substance is incomplete and for a combination of these two conditions.
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