Journal ArticleDOI
Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B.
William E. Klunk,Henry Engler,Agneta Nordberg,Yanming Wang,G. Blomqvist,Daniel P. Holt,Mats Bergström,Irina Savitcheva,Guo Feng Huang,Sergio Estrada,Birgitta Ausén,Manik L. Debnath,Julien Barletta,Julie C. Price,Johan Sandell,Brian J. Lopresti,Anders Wall,Pernilla Koivisto,Gunnar Antoni,Chester A. Mathis,Bengt Långström +20 more
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TLDR
The results suggest that PET imaging with the novel tracer, PIB, can provide quantitative information on amyloid deposits in living subjects.Abstract:
This report describes the first human study of a novel amyloid-imaging positron emission tomography (PET) tracer, termed Pittsburgh Compound-B (PIB), in 16 patients with diagnosed mild AD and 9 controls. Compared with controls, AD patients typically showed marked retention of PIB in areas of association cortex known to contain large amounts of amyloid deposits in AD. In the AD patient group, PIB retention was increased most prominently in frontal cortex (1.94-fold, p = 0.0001). Large increases also were observed in parietal (1.71-fold, p = 0.0002), temporal (1.52-fold, p = 0.002), and occipital (1.54-fold, p = 0.002) cortex and the striatum (1.76-fold, p = 0.0001). PIB retention was equivalent in AD patients and controls in areas known to be relatively unaffected by amyloid deposition (such as subcortical white matter, pons, and cerebellum). Studies in three young (21 years) and six older healthy controls (69.5 +/- 11 years) showed low PIB retention in cortical areas and no significant group differences between young and older controls. In cortical areas, PIB retention correlated inversely with cerebral glucose metabolism determined with 18F-fluorodeoxyglucose. This relationship was most robust in the parietal cortex (r = -0.72; p = 0.0001). The results suggest that PET imaging with the novel tracer, PIB, can provide quantitative information on amyloid deposits in living subjects.read more
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High-yield, automated radiosynthesis of 2-(1-{6-[(2-[18F]fluoroethyl)(methyl)amino]-2-naphthyl}ethylidene)malononitrile ([18F]FDDNP) ready for animal or human administration.
Jie Liu,Vladimir Kepe,Alenka Žabjek,Andrej Petrič,Henry C. Padgett,Nagichettiar Satyamurthy,Jorge R. Barrio +6 more
TL;DR: A high-yield and fully automated synthesis of [18F]FDDNP—along with the synthesis and characterization of non-radioactive FDDNP, a fluorescent probe derived from 2-(1,1-dicyanopropenyl-2)-6-dimethylaminonaphthalene (DDNP)—are reported.
Journal ArticleDOI
Effects of acetylcholinesterase inhibitors and memantine on resting-state electroencephalographic rhythms in Alzheimer's disease patients
Claudio Babiloni,Claudio Del Percio,Régis Bordet,Jean Luis Bourriez,Marina Bentivoglio,Pierre Payoux,Philippe Derambure,Sophie Dix,Francesco Infarinato,Roberta Lizio,Antonio Ivano Triggiani,Jill C. Richardson,Paolo Maria Rossini +12 more
TL;DR: The expected effects of AChEIs on resting state EEG rhythms in AD patients are enlightened as promising EEG markers for the development of translational protocols both within the PharmaCog project and for wider use.
Journal ArticleDOI
Mild cognitive impairment should be considered for DSM-V.
TL;DR: A case for mild cognitive impairment inclusion in the Diagnostic and Statistical Manual of Mental Disorders (5th ed; DSM-V) is presented based on clinical, outcome, epidemiological, neuroimaging, and pathophysiological data.
Journal ArticleDOI
Executive Function Changes before Memory in Preclinical Alzheimer’s Pathology: A Prospective, Cross-Sectional, Case Control Study
Michael G. Harrington,Jiarong Chiang,Janice M. Pogoda,Megan Gomez,Kris Thomas,Sarah DeBoard Marion,Karen J. Miller,Prabha Siddarth,Xinyao Yi,Feimeng Zhou,Sherri Lee,Xianghong Arakaki,Robert Cowan,Thao Tran,Cherise Charleswell,Brian D. Ross,Alfred N. Fonteh +16 more
TL;DR: It is proposed that Stroop Interference may be an additional important screen for early pathology and useful to monitor treatment of preclinical Alzheimer’s disease; measures of executive and memory functions in a longitudinal design will be necessary to more fully evaluate this approach.
Journal ArticleDOI
Reference measurement procedure for CSF amyloid beta (Aβ)1-42 and the CSF Aβ1-42 /Aβ1-40 ratio - a cross-validation study against amyloid PET.
Josef Pannee,Erik Portelius,Lennart Minthon,Johan Gobom,Ulf Andreasson,Henrik Zetterberg,Henrik Zetterberg,Oskar Hansson,Kaj Blennow +8 more
TL;DR: Cross‐validation of the reference measurement procedure as well as the Aβ1–42/Aβ1-40 and Aβ2–42–Aβ3–40 ratios in CSF show that they are strongly associated with cortical Aβ fibrils measured by 18F‐flutemetamol PET.
References
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Graphical Evaluation of Blood-to-Brain Transfer Constants from Multiple-Time Uptake Data. Generalizations:
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