Journal ArticleDOI
Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B.
William E. Klunk,Henry Engler,Agneta Nordberg,Yanming Wang,G. Blomqvist,Daniel P. Holt,Mats Bergström,Irina Savitcheva,Guo Feng Huang,Sergio Estrada,Birgitta Ausén,Manik L. Debnath,Julien Barletta,Julie C. Price,Johan Sandell,Brian J. Lopresti,Anders Wall,Pernilla Koivisto,Gunnar Antoni,Chester A. Mathis,Bengt Långström +20 more
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TLDR
The results suggest that PET imaging with the novel tracer, PIB, can provide quantitative information on amyloid deposits in living subjects.Abstract:
This report describes the first human study of a novel amyloid-imaging positron emission tomography (PET) tracer, termed Pittsburgh Compound-B (PIB), in 16 patients with diagnosed mild AD and 9 controls. Compared with controls, AD patients typically showed marked retention of PIB in areas of association cortex known to contain large amounts of amyloid deposits in AD. In the AD patient group, PIB retention was increased most prominently in frontal cortex (1.94-fold, p = 0.0001). Large increases also were observed in parietal (1.71-fold, p = 0.0002), temporal (1.52-fold, p = 0.002), and occipital (1.54-fold, p = 0.002) cortex and the striatum (1.76-fold, p = 0.0001). PIB retention was equivalent in AD patients and controls in areas known to be relatively unaffected by amyloid deposition (such as subcortical white matter, pons, and cerebellum). Studies in three young (21 years) and six older healthy controls (69.5 +/- 11 years) showed low PIB retention in cortical areas and no significant group differences between young and older controls. In cortical areas, PIB retention correlated inversely with cerebral glucose metabolism determined with 18F-fluorodeoxyglucose. This relationship was most robust in the parietal cortex (r = -0.72; p = 0.0001). The results suggest that PET imaging with the novel tracer, PIB, can provide quantitative information on amyloid deposits in living subjects.read more
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Journal ArticleDOI
Regional dynamics of amyloid-β deposition in healthy elderly, mild cognitive impairment and Alzheimer’s disease: a voxelwise PiB–PET longitudinal study
Nicolas Villain,Gaël Chételat,Blandine Grassiot,Pierrick Bourgeat,Gareth Jones,Kathryn A. Ellis,David Ames,Ralph N. Martins,Francis Eustache,Olivier Salvado,Colin L. Masters,Christopher C. Rowe,Victor L. Villemagne +12 more
TL;DR: This study identified the existence of Pittsburgh compound 'accumulator' and 'non-accumulators', notably within the Pittsburgh compound B-negative group, which may be a relevant concept for future studies.
Journal ArticleDOI
The role of biomarkers in clinical trials for Alzheimer disease.
Leon J. Thal,Kejal Kantarci,Eric M. Reiman,William E. Klunk,Michael Weiner,Michael Weiner,Henrik Zetterberg,Henrik Zetterberg,Douglas Galasko,Domenico Praticò,Sue T. Griffin,Dale Schenk,Eric Siemers +12 more
TL;DR: This review summarizes a meeting of the Alzheimer's Association's Research Roundtable, during which existing and emerging biomarkers for AD were evaluated, and currently appropriate uses of biomarkers in the study of Alzheimer disease, and areas where additional work is needed are discussed.
Journal ArticleDOI
F-18 Polyethyleneglycol stilbenes as PET imaging agents targeting Aβ aggregates in the brain
TL;DR: The preliminary results strongly suggest 18F-labeled polyethyleneglycol (PEG)-stilbene derivatives are suitable candidates as Abeta plaque imaging agents for studying patients with Alzheimer's disease.
Journal ArticleDOI
Mild cognitive impairment.
Howard Feldman,Claudia Jacova +1 more
TL;DR: Although there are no pharmacological treatments at present that are capable of delaying the long-term progression of MCI to dementia, there is some evidence of short-term symptomatic benefits with acetylcholinesterase inhibitors.
Journal ArticleDOI
Brain Amyloid Imaging
TL;DR: Nuclear medicine physicians are provided with the background knowledge required for understanding this emerging investigation, including its appropriate use, and prepare them for practical training in scan interpretation.
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Graphical Evaluation of Blood-to-Brain Transfer Constants from Multiple-Time Uptake Data. Generalizations:
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