Journal ArticleDOI
Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B.
William E. Klunk,Henry Engler,Agneta Nordberg,Yanming Wang,G. Blomqvist,Daniel P. Holt,Mats Bergström,Irina Savitcheva,Guo Feng Huang,Sergio Estrada,Birgitta Ausén,Manik L. Debnath,Julien Barletta,Julie C. Price,Johan Sandell,Brian J. Lopresti,Anders Wall,Pernilla Koivisto,Gunnar Antoni,Chester A. Mathis,Bengt Långström +20 more
TLDR
The results suggest that PET imaging with the novel tracer, PIB, can provide quantitative information on amyloid deposits in living subjects.Abstract:
This report describes the first human study of a novel amyloid-imaging positron emission tomography (PET) tracer, termed Pittsburgh Compound-B (PIB), in 16 patients with diagnosed mild AD and 9 controls. Compared with controls, AD patients typically showed marked retention of PIB in areas of association cortex known to contain large amounts of amyloid deposits in AD. In the AD patient group, PIB retention was increased most prominently in frontal cortex (1.94-fold, p = 0.0001). Large increases also were observed in parietal (1.71-fold, p = 0.0002), temporal (1.52-fold, p = 0.002), and occipital (1.54-fold, p = 0.002) cortex and the striatum (1.76-fold, p = 0.0001). PIB retention was equivalent in AD patients and controls in areas known to be relatively unaffected by amyloid deposition (such as subcortical white matter, pons, and cerebellum). Studies in three young (21 years) and six older healthy controls (69.5 +/- 11 years) showed low PIB retention in cortical areas and no significant group differences between young and older controls. In cortical areas, PIB retention correlated inversely with cerebral glucose metabolism determined with 18F-fluorodeoxyglucose. This relationship was most robust in the parietal cortex (r = -0.72; p = 0.0001). The results suggest that PET imaging with the novel tracer, PIB, can provide quantitative information on amyloid deposits in living subjects.read more
Citations
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Journal ArticleDOI
The pattern of amyloid accumulation in the brains of adults with Down syndrome
Tiina Annus,Liam R. Wilson,Young T. Hong,Julio Acosta–Cabronero,Tim D. Fryer,Arturo Cardenas–Blanco,Robert Smith,Istvan Boros,Jonathan P. Coles,Franklin I. Aigbirhio,David K. Menon,Shahid Zaman,Shahid Zaman,Peter J. Nestor,Anthony J. Holland,Anthony J. Holland +15 more
TL;DR: Adults with Down syndrome (DS) invariably develop Alzheimer's disease (AD) neuropathology and understanding amyloid deposition in DS can yield crucial information about disease pathogenesis.
Journal ArticleDOI
The dynamics of Alzheimer's disease biomarkers in the Alzheimer's Disease Neuroimaging Initiative cohort
Anna Caroli,Giovanni B. Frisoni +1 more
TL;DR: This study provides the first evidence in favor of the dynamic biomarker model which has recently been proposed, and cerebro-spinal fluid tau and hippocampal volume changed later showing similar monotonous trends, reflecting disease progression.
Journal ArticleDOI
Brain inflammation accompanies amyloid in the majority of mild cognitive impairment cases due to Alzheimer's disease.
Peter Parbo,Rola Ismail,Kim V. Hansen,Ali Amidi,Frederik H Mårup,Hanne Gottrup,Hans Brændgaard,Bengt O Eriksson,Simon Fristed Eskildsen,Torben Ellegaard Lund,Anna Tietze,Paul Edison,Nicola Pavese,Nicola Pavese,Morten Gersel Stokholm,Per Borghammer,Rainer Hinz,Joel Aanerud,David J. Brooks,David J. Brooks,David J. Brooks +20 more
TL;DR: Increased inflammation occurs early in Alzheimer's disease and would be present in most amyloid-positive mild cognitive impairment cases, its cortical distribution overlapping that of amyloids deposition.
Journal ArticleDOI
The Eye As a Biomarker for Alzheimer's Disease.
Jeremiah K.H. Lim,Qiao-Xin Li,Zheng He,Algis J. Vingrys,Vickie H. Y. Wong,Nicolas Currier,Jamie Mullen,Bang V. Bui,Christine T. O. Nguyen +8 more
TL;DR: The development of ocular biomarkers can have far implications in the discovery of treatments which can improve the quality of lives of patients, and potential future avenues of research in this area are explored.
Journal ArticleDOI
Amyloid Imaging With Carbon 11–Labeled Pittsburgh Compound B for Traumatic Brain Injury
Young T. Hong,Tonny Veenith,Deborah Dewar,Joanne G. Outtrim,Vaithianadan Mani,Claire Williams,Sally L. Pimlott,Peter J. Hutchinson,Adriana Tavares,Roberto Canales,Chester A. Mathis,William E. Klunk,Franklin I. Aigbirhio,Jonathan P. Coles,Jean-Claude Baron,Jean-Claude Baron,John D. Pickard,Tim D. Fryer,William Stewart,David K. Menon +19 more
TL;DR: Compared with the controls, the patients with TBI showed significantly increased [11C]PiB distribution volume ratios in cortical gray matter and the striatum, but not in the thalamus or white matter, and this binding could be valuable in imaging amyloid deposition following TBI.
References
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