Journal ArticleDOI
Immunologic mechanisms in asthma.
TLDR
The immunologic mechanism of heterogenous asthma phenotypes is focused on, which contains heterogeneous group of endoypes and phenotypes, such as exercise-induced asthma, obesity induced asthma, etc.About:
This article is published in Seminars in Immunology.The article was published on 2019-12-01. It has received 252 citations till now. The article focuses on the topics: Asthma & Eosinophil.read more
Citations
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Journal ArticleDOI
Type 2 immunity in the skin and lungs.
Cezmi A. Akdis,Peter D. Arkwright,Marie-Charlotte Brüggen,William W. Busse,Massimo Gadina,Emma Guttman-Yassky,Emma Guttman-Yassky,Kenji Kabashima,Kenji Kabashima,Yasutaka Mitamura,Laura Vian,Jianni Wu,Jianni Wu,Oscar Palomares +13 more
TL;DR: The present review aims to highlight recent advances in type 2 immunity and discuss the cellular sources, targets, and roles of type 2 mechanisms in asthma and AD.
Iconographies supplémentaires de l'article : Airway epithelial cells from asthmatic children differentially express proremodeling factors
Jesus M. Lopez-Guisa,Claire Powers,Daniele File,Elizabeth Cochrane,Nathalia Jimenez,Jason S. Debley +5 more
TL;DR: Nasal epithelial cells might be a suitable surrogate for bronchial cells that could facilitate investigation of the airway epithelium in future longitudinal pediatric studies.
Journal ArticleDOI
EAACI Biologicals Guidelines—Recommendations for severe asthma
Ioana Agache,Cezmi A. Akdis,Mübeccel Akdis,Giorgio Walter Canonica,Thomas B. Casale,Tomas Chivato,Jonathan Corren,Derek K. Chu,Stefano Del Giacco,Thomas Eiwegger,Breda Flood,Davide Firinu,James E. Gern,Eckard Hamelmann,Nicola A. Hanania,Irene Hernández-Martín,Rebeca Knibb,Mika J. Mäkelä,Parameswaran Nair,Liam O’ Mahony,Nikolaos G. Papadopoulos,Nikolaos G. Papadopoulos,Alberto Papi,Hae-Sim Park,Luis Pérez de Llano,Oliver Pfaar,Santiago Quirce,Joaquín Sastre,Mohamed H. Shamji,Mohamed H. Shamji,Jürgen Schwarze,Oscar Palomares,Marek Jutel,Marek Jutel +33 more
TL;DR: The EAACI Guidelines on the use of biologicals in severe asthma follow the GRADE approach in formulating recommendations for each biological and each outcome, together with future approaches and research priorities.
Journal ArticleDOI
Efficacy and safety of treatment with biologicals (benralizumab, dupilumab and omalizumab) for severe allergic asthma: A systematic review for the EAACI Guidelines - recommendations on the use of biologicals in severe asthma
Ioana Agache,Claudio Rocha,Jessica Beltran,Yang Song,Margarita Posso,Ivan Solà,Pablo Alonso-Coello,Cezmi A. Akdis,Mübeccel Akdis,Giorgio Walter Canonica,Thomas B. Casale,Tomas Chivato,Jonathan Corren,Stefano Del Giacco,Thomas Eiwegger,Davide Firinu,James E. Gern,Eckard Hamelmann,Nicola A. Hanania,Mika J. Mäkelä,Irene Hernández Martín,Parameswaran Nair,Parameswaran Nair,Liam O'Mahony,Nikolaos G. Papadopoulos,Nikolaos G. Papadopoulos,Alberto Papi,Hae-Sim Park,Luis Pérez de Llano,Santiago Quirce,Joaquín Sastre,Mohamed H. Shamji,Mohamed H. Shamji,Jürgen Schwarze,Carlos Canelo-Aybar,Carlos Canelo-Aybar,Oscar Palomares,Marek Jutel +37 more
TL;DR: Both benralizumab and dupilumab improved asthma control with high certainty and omalizumAB with moderate certainty; however, none reached the minimal important difference (MID).
Journal ArticleDOI
Modulating Th2 Cell Immunity for the Treatment of Asthma.
TL;DR: A recent review as discussed by the authors highlights the current understanding of the heterogeneity of the Th2 cell compartment, their contribution to allergen-induced airway inflammation, and the therapies targeting the th2 cell pathway in asthma.
References
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Mepolizumab for severe eosinophilic asthma (DREAM): a multicentre, double-blind, placebo-controlled trial.
Ian D. Pavord,Stephanie Korn,Peter H. Howarth,Eugene R. Bleecker,Roland Buhl,Oliver N. Keene,Hector Ortega,Pascal Chanez +7 more
TL;DR: Mepolizumab is an effective and well tolerated treatment that reduces the risk of asthma exacerbations in patients with severe eosinophilic asthma.
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A large-scale, consortium-based genomewide association study of asthma.
Miriam F. Moffatt,Ivo Gut,Florence Demenais,David P. Strachan,Emmanuelle Bouzigon,Simon Heath,Erika von Mutius,Martin Farrall,Mark Lathrop,William O.C.M. Cookson +9 more
TL;DR: A few common alleles are associated with disease risk at all ages and suggest a role for communication of epithelial damage to the adaptive immune system and activation of airway inflammation in asthma.
Supplementary materials to a paper "A large-scale, consortium-based genomewide association study of asthma"
Moffatt Mf,Gut Ig,F. Demenais,Strachan Dp,E. Bouzigon,S. Heath,A. Kumar,P. Burney,D. Jarvis,M. Wjst,M. Kogevinas,R. Jogi,C. Janson,Franklin Ka,E. Omenaas,B. Leynaert,I. Pin,J. Heinrich,Probst Hensch Nm,Anto Jm,J. Sunyer,Maldonado Ja,J. Martinez Moratalla,I. Urrutia,F. Payo,F. Kauffmann,Dizier Mh,V. Siroux,A. Boznanski,C. Braun Fahrländer,J. Genuneit,J. Glas,E. Horak,M. Kabesch,Pillai Sg,Helms Pj,K. Carlsen,Carlsen Kh,J. Gerritsen,M. Silverman,P. Sly,J. Tsanakas,A. Von Berg,M. Whyte,M. Blumenthal,M. Imboden,T. Rochat,Thun Ga,Gerbase Mw,I. Curjuric,Gaspoz Jm,Liu Lj,Wouters Im,T. Sigsgaard,D. Heederik,I. Basinas,V. Schlunssen,Ø. Omland,P. Cullinan,R. Vermeulen,J. Henderson,R. Granell,McArdle Wl,Smith Gd,James Al,J. Hui,Palmer Lj,J. Beilby,Musk Aw,C. Laprise,Hudson Tj,M. Lemire,D. Daley,A. Becker,M. Chan Yeung,A. Sandford,Kozyrskyj Al,P. Paré,A. Ferguson,H. Dimich Ward,Watson Wt,Freidin Mb,Bragina EIu,Deev Ia,Deeva Ev,Kobyakova Os,Puzyrev Vp,Ogorodova Lm,Khusnutdinova Ek,Karunas As,Fedorova Yy,Hall Ip,I. Sayers,Tobin Md,Wan Yi,Heaney Lg,Al Momani Ba,Mansur Ah,S. Manney,Thomson Nc,R. Chaudhuri,Brightling Ce,M. Bafadhel,A. Singapuri,R. Niven,A. Simpson,Holloway Jw,Howarth Ph,Polonikov Av,Ivanov Vp,Solodilova Ma,E. Melén,G. Pershagen,A. Bergström,I. Kull,F. Nyberg,M. Wickman,C. Söderhäll,J. Kere,Postma Ds,M. Kerkhof,B. Brunekreef,Smit Ha,de Jongste Jc,A. Wijga,Aalberse Rc,Hoekstra Mo,Koppelman Gh,A. Binia,Chung Kf,P. Bhavsar,F. Chow,P. Macedo,A. Menzies Gow,N. van Stiphout,A. Bush,Lee Ya,J. Esparza Gordillo,R. Nickel,U. Wahn,S. Lau,I. Marenholz,T. Haahtela,L. von Hertzen,P. Jousilahti,T. Laatikainen,Mäkelä Mj,E. Vartiainen,T. Laitinen,Balding Dj,Peden Jf,E. Corda,D. Lechner,C. Besse,D. Zelenika,A. Boland,D. Bacq,S. Demonchy,H. Blanche,Y. Kamatani,E. von Mutius,M. Farrall,M. Lathrop,Cookson Wo +163 more
Journal ArticleDOI
Human IL-25- and IL-33-responsive type 2 innate lymphoid cells are defined by expression of CRTH2 and CD161.
Jenny Mjösberg,Sara Trifari,Sara Trifari,Natasha K Crellin,Natasha K Crellin,Charlotte P. Peters,Cornelis M. van Drunen,Berber Piet,Wytske Fokkens,Tom Cupedo,Hergen Spits +10 more
TL;DR: This work describes another lineage-negative CD127+CD161+ ILC population found in humans that expressed the chemoattractant receptor CRTH2 and identifies a unique type of human ILC that provides an innate source of T helper type 2 (TH2) cytokines.
Journal ArticleDOI
The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17–producing effector T helper cells in vivo
Mandy J. McGeachy,Yi Chen,Cristina M. Tato,Arian Laurence,Barbara Joyce-Shaikh,Wendy M. Blumenschein,Terrill K. McClanahan,John J. O'Shea,Daniel J. Cua +8 more
TL;DR: In the absence of IL-23, TH- 17 development was stalled at the early activation stage and fewer effector TH-17 cells were produced in the lymph nodes and hence available to emigrate to the bloodstream and tissues.
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