Journal ArticleDOI
Immunological biomarkers of tuberculosis.
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TLDR
Interplay between the host immune system and M. tuberculosis may provide a platform for the identification of suitable biomarkers, through both unbiased and targeted hypothesis-driven approaches.Abstract:
Currently there are no sufficiently validated biomarkers to aid the evaluation of new tuberculosis vaccine candidates, the improvement of tuberculosis diagnostics or the development of more effective and shorter treatment regimens. To date, the detection of Mycobacterium tuberculosis or its products has not been able to adequately address these needs. Understanding the interplay between the host immune system and M. tuberculosis may provide a platform for the identification of suitable biomarkers, through both unbiased and targeted hypothesis-driven approaches. Here, we review immunological markers, their relation to M. tuberculosis infection stages and their potential use in the fight against tuberculosis.read more
Citations
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Journal ArticleDOI
The Immune Response in Tuberculosis
Anne O'Garra,Paul S. Redford,Finlay W. McNab,Chloe I Bloom,Robert J. Wilkinson,Matthew Berry +5 more
TL;DR: What the authors know about the immune response in tuberculosis, in human disease, and in a range of experimental models is summarized, all of which are essential to advancing the mechanistic knowledge base of the host-pathogen interactions that influence disease outcome.
Journal ArticleDOI
Advances in the development of new tuberculosis drugs and treatment regimens
TL;DR: Current concepts and recent advances in TB drug discovery and development are covered, including an update of ongoing TB treatment trials, newer clinical trial designs, TB biomarkers and adjunct host-directed therapies.
Journal ArticleDOI
A blood RNA signature for tuberculosis disease risk: a prospective cohort study.
Daniel E. Zak,Adam Penn-Nicholson,Thomas J. Scriba,Ethan G. Thompson,Sara Suliman,Lynn M. Amon,Hassan Mahomed,Mzwandile Erasmus,Wendy Whatney,Gregory D. Hussey,Deborah Abrahams,Fazlin Kafaar,Tony Hawkridge,Suzanne Verver,E. Jane Hughes,Martin O. C. Ota,Jayne S. Sutherland,Rawleigh Howe,Hazel M. Dockrell,W. Henry Boom,Bonnie Thiel,Tom H. M. Ottenhoff,Harriet Mayanja-Kizza,Amelia C. Crampin,Katrina Downing,Mark Hatherill,Joe Valvo,Smitha Shankar,Shreemanta K. Parida,Stefan H. E. Kaufmann,Gerhard Walzl,Alan Aderem,Willem A. Hanekom +32 more
TL;DR: The whole blood tuberculosis risk signature prospectively identified people at risk of developing active tuberculosis, opening the possibility for targeted intervention to prevent the disease.
Journal ArticleDOI
The immunological life cycle of tuberculosis.
TL;DR: It is proposed that there are distinct stages in the immune response to M. tuberculosis that form an 'immunological life cycle' and this thesis will provide a framework for investigation to understand immunity toM.
Journal ArticleDOI
Sterilization of granulomas is common in active and latent tuberculosis despite within-host variability in bacterial killing
Philana Ling Lin,Christopher B. Ford,Christopher B. Ford,M. Teresa Coleman,Amy J. Myers,Richa Gawande,Thomas R. Ioerger,James C. Sacchettini,Sarah M. Fortune,Sarah M. Fortune,Sarah M. Fortune,JoAnne L. Flynn +11 more
TL;DR: This work uses individually marked Mtb isolates and quantitative measures of culturable and cumulative bacterial burden to show that most lung lesions are probably founded by a single bacterium and reach similar maximum burdens, and suggests that lesional heterogeneity arises through differential killing of bacteria after the onset of adaptive immunity.
References
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Journal ArticleDOI
An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis
Matthew Berry,Christine M. Graham,Finlay W. McNab,Zhaohui Xu,Susannah Bloch,Tolu Oni,Tolu Oni,Katalin A. Wilkinson,Katalin A. Wilkinson,Romain Banchereau,Jason A. Skinner,Robert J. Wilkinson,Robert J. Wilkinson,Robert J. Wilkinson,Charles T. Quinn,Derek Blankenship,Ranju Dhawan,John J. Cush,Asuncion Mejias,Octavio Ramilo,Onn Min Kon,Virginia Pascual,Jacques Banchereau,Damien Chaussabel,Anne O'Garra +24 more
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Journal ArticleDOI
Physiological and pathological roles for microRNAs in the immune system
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Journal ArticleDOI
IL-23 and IL-17 in the establishment of protective pulmonary CD4 + T cell responses after vaccination and during Mycobacterium tuberculosis challenge
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TL;DR: It is proposed that vaccination induces IL-17-producing CD4+ T cells that populate the lung and, after challenge, trigger the production of chemokines that recruit CD4- T cells producing interferon-γ, which ultimately restrict bacterial growth.
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An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis
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