Induction of Airway Mucus Production By T Helper 2 (Th2) Cells: A Critical Role For Interleukin 4 In Cell Recruitment But Not Mucus Production
TLDR
It is suggested that IL-4 is crucial for Th2 cell recruitment to the lung and for induction of inflammation, but has no direct role in mucus production.Abstract:
Airway inflammation is believed to stimulate mucus production in asthmatic patients. Increased mucus secretion is an important clinical symptom and contributes to airway obstruction in asthma. Activated CD4 Th1 and Th2 cells have both been identified in airway biopsies of asthmatics but their role in mucus production is not clear. Using CD4 T cells from mice transgenic for the OVA-specific TCR, we studied the role of Th1 and Th2 cells in airway inflammation and mucus production. Airway inflammation induced by Th2 cells was comprised of eosinophils and lymphocytes; features found in asthmatic patients. Additionally, there was a marked increase in mucus production in mice that received Th2 cells and inhaled OVA, but not in mice that received Th1 cells. However, OVA-specific Th2 cells from IL-4–deficient mice were not recruited to the lung and did not induce mucus production. When this defect in homing was overcome by administration of TNF-α, IL-4 −/− Th2 cells induced mucus as effectively as IL-4 +/+ Th2 cells. These studies establish a role for Th2 cells in mucus production and dissect the effector functions of IL-4 in these processes. These data suggest that IL-4 is crucial for Th2 cell recruitment to the lung and for induction of inflammation, but has no direct role in mucus production.read more
Citations
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Journal ArticleDOI
IgE Cross-Linking or Lipopolysaccharide Treatment Induces Recruitment of Th2 Cells to the Lung in the Absence of Specific Antigen
Robin Stephens,David D. Chaplin +1 more
TL;DR: The data suggest that Th2 cells of the adaptive immune response are similar to cells ofThe innate immune response in their lack of requirement for protein Ag to initiate cell recruitment and demonstrate further that recruitment can occur independently of Ag-dependent activation.
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A Novel Pathway That Regulates Inflammatory Disease in the Respiratory Tract
TL;DR: It is shown that Th1- and Th2-induced airway inflammation followed by repeated exposure to inhaled Ag leads to a state of immunosuppression, and induction of this pathway may offer potent localized treatment of chronic T cell-mediated respiratory illnesses and provide insights into the development of such diseases.
Journal ArticleDOI
Interleukin-4-promoted T helper 2 responses enhance Nippostrongylus brasiliensis-induced pulmonary pathology.
Helen Mearns,William G. C. Horsnell,J. Claire Hoving,Benjamin G Dewals,Antony J. Cutler,Frank Kirstein,Elmarie Myburgh,Berenice Arendse,Frank Brombacher +8 more
TL;DR: It is demonstrated that CD4+ T-cell IL-4 responsiveness facilitates eosinophil and lymphocyte recruitment, lymphocyte localization, and TH2 cytokine production in the allergic pathology associated with N. brasiliensis infections.
Journal ArticleDOI
Transfer of in vivo primed transgenic T cells supports allergic lung inflammation and FIZZ1 and Ym1 production in an IL-4Rα and STAT6 dependent manner.
TL;DR: It is established that transfer of in vivo primed CD4+ T cells can induce allergic lung inflammation and eosinophilia are only partially dependent on this pathway, although further studies are required to identify other proteins and signaling pathways involved in airway inflammation.
Journal ArticleDOI
Both Th1 and Th2 cells require P-selectin glycoprotein ligand-1 for optimal rolling on inflamed endothelium.
Paul R. Mangan,Darrell B. O'Quinn,Laurie E. Harrington,Claudine S. Bonder,Paul Kubes,Dennis F. Kucik,Daniel C. Bullard,Casey T. Weaver +7 more
TL;DR: Both Th1 and Th2 populations express functional PS GL-1-based selectin ligands for tethering and rolling on activated endothelium, and both effector populations can use PSGL-1 as the dominant scaffold for functional selectinligand expression.
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