Open AccessJournal Article
Interleukin-13: Central mediator of allergic asthma
Marsha Wills-Karp,Jackie Luyimbazi,Xueying Xu,Brian Schofield,Tamlyn Neben,Christopher L. Karp,Debra D. Donaldson +6 more
TLDR
In this article, the type 2 cytokine IL-13, which shares a receptor component and signaling pathways with IL-4, was found to be necessary and sufficient for the expression of allergic asthma.Abstract:
The worldwide incidence, morbidity, and mortality of allergic asthma are increasing. The pathophysiological features of allergic asthma are thought to result from the aberrant expansion of CD4 + T cells producing the type 2 cytokines interleukin-4 (IL-4) and IL-5, although a necessary role for these cytokines in allergic asthma has not been demonstrable. The type 2 cytokine IL-13, which shares a receptor component and signaling pathways with IL-4, was found to be necessary and sufficient for the expression of allergic asthma. IL-13 induces the pathophysiological features of asthma in a manner that is independent of immunoglobulin E and eosinophils. Thus, IL-13 is critical to allergen-induced asthma but operates through mechanisms other than those that are classically implicated in allergic responses.read more
Citations
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Journal ArticleDOI
The Th2 lymphocyte products IL-4 and IL-13 rapidly induce airway hyperresponsiveness through direct effects on resident airway cells.
TL;DR: Airway inflammation and airway hyperresponsiveness are hallmarks of asthma and products of activated Th2 lymphocytes can rapidly perturb airway function through direct effects on resident airway cells, suggesting a critical role for interleukin (IL)-4 and/or IL-13.
Journal ArticleDOI
Significant Involvement of CCL2 (MCP-1) in Inflammatory Disorders of the Lung
TL;DR: Future studies are needed to determine if CCL2/CCR2 antagonism will offer breakthrough therapy for patients with allergic asthma, IPF, or BOS, and to confirm the hypothesis that CCL1 polymorphism places patients at greater risk for these disorders.
Journal ArticleDOI
Differential regulation of dual NADPH oxidases/peroxidases, Duox1 and Duox2, by Th1 and Th2 cytokines in respiratory tract epithelium.
Richart W Harper,Changhong Xu,Jason P. Eiserich,Yin Chen,Cheng Yuan Kao,Philip Thai,Henny Setiadi,Reen Wu +7 more
TL;DR: The regulation of Duox expression by immunomodulatory Th1 and Th2 cytokines is demonstrated for the first time, and a mechanism by which ROS production can be regulated in the respiratory tract as part of the host defense response is suggested.
Journal ArticleDOI
Eosinophil Cytokines, Chemokines, and Growth Factors: Emerging Roles in Immunity
Francis Davoine,Paige Lacy +1 more
TL;DR: The focus of this review is to describe the cytokines, growth factors, and chemokines that are elaborated by eosinophils, and to illustrate some of the intracellular events leading to the release of eos inophil-derived cytokines.
Journal ArticleDOI
A novel subset of mouse NKT cells bearing the IL-17 receptor B responds to IL-25 and contributes to airway hyperreactivity
Asuka Terashima,Hiroshi Watarai,Sayo Inoue,Etsuko Sekine,Ryusuke Nakagawa,Koji Hase,Chiaki Iwamura,Hiroshi Nakajima,Toshinori Nakayama,Masaru Taniguchi +9 more
TL;DR: A novel subset of natural killer T cells that expresses the interleukin 17 receptor B for IL-25 and is essential for the induction of AHR is identified, suggesting that IL-17RB+ CD4+ NKT cells play a crucial role in the pathogenesis of asthma.
References
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Douglas S. Robinson,Qutayba Hamid,Sun Ying,Anne Tsicopoulos,J. Barkans,Andrew Bentley,Christopher Corrigan,Stephen R. Durham,A. B. Kay +8 more
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Journal ArticleDOI
Eosinophilic inflammation in asthma.
Jean Bousquet,Pascal Chanez,J.-Y. Lacoste,G. Barneon,N Ghavanian,I. Enander,Per Venge,Staffan Ahlstedt,J Simony-Lafontaine,P. Godard +9 more
TL;DR: Eosinophilic inflammation of the airways is correlated with the severity of asthma and these cells are likely to play a part in the epithelial damage seen in this disease.
Journal ArticleDOI
Requirement for IL-13 Independently of IL-4 in Experimental Asthma
Gabriele Grünig,Martha L. Warnock,Adil E. Wakil,Rajeev Venkayya,Frank Brombacher,Donna M. Rennick,Dean Sheppard,Markus Mohrs,Debra D. Donaldson,Richard M. Locksley,David B. Corry +10 more
TL;DR: This article showed that IL-4 receptor α chain-dependent pathway may underlie the genetic associations of asthma with both the human 5q31 locus and the IL4 receptor and showed that selective neutralization of IL-13, a cytokine related to interleukin-4 that also binds to the α chain of the IL 4 receptor, ameliorated asthma phenotype.
Journal ArticleDOI
Cellular events in the bronchi in mild asthma and after bronchial provocation.
TL;DR: It is concluded that allergic asthma is accompanied by extensive inflammatory changes in the airways, even in mild clinical and subclinical disease.
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