Open AccessJournal Article
Interleukin-13: Central mediator of allergic asthma
Marsha Wills-Karp,Jackie Luyimbazi,Xueying Xu,Brian Schofield,Tamlyn Neben,Christopher L. Karp,Debra D. Donaldson +6 more
TLDR
In this article, the type 2 cytokine IL-13, which shares a receptor component and signaling pathways with IL-4, was found to be necessary and sufficient for the expression of allergic asthma.Abstract:
The worldwide incidence, morbidity, and mortality of allergic asthma are increasing. The pathophysiological features of allergic asthma are thought to result from the aberrant expansion of CD4 + T cells producing the type 2 cytokines interleukin-4 (IL-4) and IL-5, although a necessary role for these cytokines in allergic asthma has not been demonstrable. The type 2 cytokine IL-13, which shares a receptor component and signaling pathways with IL-4, was found to be necessary and sufficient for the expression of allergic asthma. IL-13 induces the pathophysiological features of asthma in a manner that is independent of immunoglobulin E and eosinophils. Thus, IL-13 is critical to allergen-induced asthma but operates through mechanisms other than those that are classically implicated in allergic responses.read more
Citations
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Journal ArticleDOI
Airway Epithelial miRNA Expression Is Altered in Asthma
Owen D. Solberg,Edwin J. Ostrin,Michael I. Love,Jeffrey C. Peng,Nirav R. Bhakta,Lydia Hou,Christine P. Nguyen,Margaret Solon,Cindy N. Nguyen,Andrea J. Barczak,Lorna Zlock,Denitza P. Blagev,Walter E. Finkbeiner,K. Mark Ansel,Joseph R. Arron,David J. Erle,Prescott G. Woodruff +16 more
TL;DR: Dramatic alterations of airway epithelial cell miRNA levels are a common feature of asthma, and IL-13 effects may account for some of these alterations, including repression of miR-34/449 family members that have established roles in airway endothelial cell differentiation.
Journal Article
Interleukin-13 Modulates Collagen Homeostasis in Human Skin and Keloid Fibroblasts
Alfonso Oriente,Neal S. Fedarko,Sarah E. Pacocha,Shau Ku Huang,Lawrence M. Lichtenstein,David M. Essayan +5 more
TL;DR: Both the profibrotic effects of IL-13 on collagen homeostasis and the potential differential regulation of collagenHomeostasis in fibroblast subtypes by IL- 13 are demonstrated.
Journal ArticleDOI
The differential expression of IL-4 and IL-13 and its impact on type-2 immunity.
Katherine Bao,R. Lee Reinhardt +1 more
TL;DR: This review summarizes the literature surrounding the function and expression of IL-4 and IL-13 in CD4+ T cells and innate immune cells and highlights recent findings in vivo regarding the differential expression and non-canonical regulation of IL/IL-4 in various immune cells, which likely play important and underappreciated roles in type-2 immunity.
Journal ArticleDOI
Eosinophils Express Functional IL-13 in Eosinophilic Inflammatory Diseases
Peter Schmid-Grendelmeier,Frank Altznauer,Barbra Fischer,Christian Bizer,Alex Straumann,Günter Menz,Kurt Blaser,Brunello Wüthrich,Hans-Uwe Simon +8 more
TL;DR: Human eosinophils are able to produce and release functional IL-13 in eosInophilic inflammatory responses, and when blood eos inophils from control individuals were stimulated with GM-CSF or IL-5 in vitro, they generatedIL-13 mRNA and protein, suggesting that IL- 13 expression by eosINophils under inflammatory conditions is a cytokine-driven process.
Journal ArticleDOI
Dissecting asthma using focused transgenic modeling and functional genomics
Douglas A. Kuperman,Christina C. Lewis,Prescott G. Woodruff,Madeleine W. Rodriguez,Yee Hwa Yang,Gregory Dolganov,John V. Fahy,David J. Erle +7 more
TL;DR: The combination of focused transgenic models, DNA microarray analyses, and translational studies provides a powerful approach for analyzing the contributions of specific mediators and cell types and for focusing attention on a limited number of genes associated with specific pathophysiologic aspects of asthma.
References
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Jean Bousquet,Pascal Chanez,J.-Y. Lacoste,G. Barneon,N Ghavanian,I. Enander,Per Venge,Staffan Ahlstedt,J Simony-Lafontaine,P. Godard +9 more
TL;DR: Eosinophilic inflammation of the airways is correlated with the severity of asthma and these cells are likely to play a part in the epithelial damage seen in this disease.
Journal ArticleDOI
Requirement for IL-13 Independently of IL-4 in Experimental Asthma
Gabriele Grünig,Martha L. Warnock,Adil E. Wakil,Rajeev Venkayya,Frank Brombacher,Donna M. Rennick,Dean Sheppard,Markus Mohrs,Debra D. Donaldson,Richard M. Locksley,David B. Corry +10 more
TL;DR: This article showed that IL-4 receptor α chain-dependent pathway may underlie the genetic associations of asthma with both the human 5q31 locus and the IL4 receptor and showed that selective neutralization of IL-13, a cytokine related to interleukin-4 that also binds to the α chain of the IL 4 receptor, ameliorated asthma phenotype.
Journal ArticleDOI
Cellular events in the bronchi in mild asthma and after bronchial provocation.
TL;DR: It is concluded that allergic asthma is accompanied by extensive inflammatory changes in the airways, even in mild clinical and subclinical disease.
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