Open AccessJournal Article
Interleukin-13: Central mediator of allergic asthma
Marsha Wills-Karp,Jackie Luyimbazi,Xueying Xu,Brian Schofield,Tamlyn Neben,Christopher L. Karp,Debra D. Donaldson +6 more
TLDR
In this article, the type 2 cytokine IL-13, which shares a receptor component and signaling pathways with IL-4, was found to be necessary and sufficient for the expression of allergic asthma.Abstract:
The worldwide incidence, morbidity, and mortality of allergic asthma are increasing. The pathophysiological features of allergic asthma are thought to result from the aberrant expansion of CD4 + T cells producing the type 2 cytokines interleukin-4 (IL-4) and IL-5, although a necessary role for these cytokines in allergic asthma has not been demonstrable. The type 2 cytokine IL-13, which shares a receptor component and signaling pathways with IL-4, was found to be necessary and sufficient for the expression of allergic asthma. IL-13 induces the pathophysiological features of asthma in a manner that is independent of immunoglobulin E and eosinophils. Thus, IL-13 is critical to allergen-induced asthma but operates through mechanisms other than those that are classically implicated in allergic responses.read more
Citations
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Journal ArticleDOI
High Dose Allergen Stimulation of T Cells from House Dust Mite-Allergic Subjects Induces Expansion of IFN-γ+ T Cells, Apoptosis of CD4+IL-4+ T Cells and T Cell Anergy
TL;DR: Results show that T cell division and apoptosis contribute to the cytokine skewing to predominant IFN-γ production by T cells observed at high allergen concentration, and the use of hypoallergenic T cell reactive preparations which can be given safely at higher doses than natural extracts may enhance efficacy of allergenic-specific immunotherapy.
Journal ArticleDOI
IL-13 production by donor T cells is prognostic of acute graft-versus-host disease following unrelated donor stem cell transplantation
William J. Jordan,Paul Brookes,Richard Szydlo,John M. Goldman,Robert I. Lechler,Mary A. Ritter +5 more
TL;DR: Novel associations between donor T-cell cytokine production during donor-antipatient mixed lymphocyte reactions (MLRs) and acute graft-versus-host disease (aGVHD) are described, high-lighting a novel and highly significant link between the Th2-type cytokine IL-13 and aGVHD.
Journal ArticleDOI
Opposing actions of Stat1 and Stat6 on IL-13-induced up-regulation of early growth response-1 and platelet-derived growth factor ligands in pulmonary fibroblasts.
Jennifer L. Ingram,Aurita Antao-Menezes,James B. Mangum,Otis Lyght,Patty J. Lee,Jack A. Elias,James C. Bonner +6 more
TL;DR: The findings support the hypothesis that Stat6 and Stat1 exert stimulatory and inhibitory effects on Egr-1 and PDGF ligand mRNA transcription, respectively, and could aid in identifying molecular targets for the treatment of chronic airway remodeling and fibrosis in asthma.
Journal ArticleDOI
Activation of interleukin-13 expression in T cells from HTLV-1-infected individuals and in chronically infected cell lines
Hye-kyung Chung,Howard A. Young,Peter K. C. Goon,Gisela Heidecker,Gerald L. Princler,Osamu Shimozato,Graham P. Taylor,Charles R. M. Bangham,David Derse +8 more
TL;DR: Clinical relevance was demonstrated by immunofluorescent staining and flow cytometry of lymphocytes obtained from HTLV-1-infected patients, which revealed that IL-13 production was directly related to the level of Tax expression in the infected CD4+ T cells soon after in vitro culture.
Journal ArticleDOI
Anti-Inflammatory Effects of Ginsenoside Rg3 via NF-κB Pathway in A549 Cells and Human Asthmatic Lung Tissue.
In-Seung Lee,InJoon Uh,Ki-Suk Kim,Kang-Hoon Kim,Jiyoung Park,Yumi Kim,Ji Hoon Jung,Hee-Jae Jung,Hyeung-Jin Jang +8 more
TL;DR: Rg3 showed the significant inhibition of NF-κB activity thereby reduced COX-2 expression was determined in both IL-1β-induced inflamed A549 cell and human asthmatic airway epithelial tissues, and the secretion levels of IL-4, TNF-α, and eotaxin were significantly decreased by Rg3 in asthma tissues.
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Journal ArticleDOI
Requirement for IL-13 Independently of IL-4 in Experimental Asthma
Gabriele Grünig,Martha L. Warnock,Adil E. Wakil,Rajeev Venkayya,Frank Brombacher,Donna M. Rennick,Dean Sheppard,Markus Mohrs,Debra D. Donaldson,Richard M. Locksley,David B. Corry +10 more
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Journal ArticleDOI
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