Open AccessJournal Article
Interleukin-13: Central mediator of allergic asthma
Marsha Wills-Karp,Jackie Luyimbazi,Xueying Xu,Brian Schofield,Tamlyn Neben,Christopher L. Karp,Debra D. Donaldson +6 more
TLDR
In this article, the type 2 cytokine IL-13, which shares a receptor component and signaling pathways with IL-4, was found to be necessary and sufficient for the expression of allergic asthma.Abstract:
The worldwide incidence, morbidity, and mortality of allergic asthma are increasing. The pathophysiological features of allergic asthma are thought to result from the aberrant expansion of CD4 + T cells producing the type 2 cytokines interleukin-4 (IL-4) and IL-5, although a necessary role for these cytokines in allergic asthma has not been demonstrable. The type 2 cytokine IL-13, which shares a receptor component and signaling pathways with IL-4, was found to be necessary and sufficient for the expression of allergic asthma. IL-13 induces the pathophysiological features of asthma in a manner that is independent of immunoglobulin E and eosinophils. Thus, IL-13 is critical to allergen-induced asthma but operates through mechanisms other than those that are classically implicated in allergic responses.read more
Citations
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Journal ArticleDOI
An IL-13 promoter polymorphism associated with increased risk of allergic asthma.
van der Pouw Kraan Tc,van Veen A,L. C. M. Boeije,van Tuyl Sa,de Groot Er,S O Stapel,A.H.F. Bakker,Cornelis L. Verweij,Lucien A. Aarden,van der Zee Js +9 more
TL;DR: The identification of a novel IL-13 promoter polymorphism (C to T exchange) at position −1055 is described, and it is postulate that the presence of this polymorphism predisposes to the development of allergic asthma.
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Pathophysiology of allergic inflammation
TL;DR: Better understanding of the pathophysiology of allergic inflammation has identified new therapeutic targets but developing effective novel therapies has been challenging, and Corticosteroids are highly effective with a broad spectrum of anti‐inflammatory effects.
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Pro- versus anti-inflammatory cytokines: myth or reality.
TL;DR: This review points out that this classification is far too simplistic and provides numerous examples illustrating that a given cytokine may behave as a pro- as well as an anti-inflammatory cytokine.
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Biologic Rhythms in the Immune System
Erhard Haus,Michael H. Smolensky +1 more
TL;DR: The response of the immune system to introduction of an antigen and to challenge of the sensitized organism varies in extent in the circadian frequency range and also in lower frequencies, for example, of about a week (circaseptan) or seasonally (circannual).
Journal ArticleDOI
IL-13 induces eosinophil recruitment into the lung by an IL-5- and eotaxin-dependent mechanism.
Samuel M. Pope,Eric B. Brandt,Anil Mishra,Simon P. Hogan,Nives Zimmermann,Klaus I. Matthaei,Paul S. Foster,Marc E. Rothenberg +7 more
TL;DR: Selective components of the IL-13-induced asthma phenotype--airway eosinophilia but not mucus secretion--are differentially regulated by IL-5 and eotaxin.
References
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TL;DR: Eosinophilic inflammation of the airways is correlated with the severity of asthma and these cells are likely to play a part in the epithelial damage seen in this disease.
Journal ArticleDOI
Requirement for IL-13 Independently of IL-4 in Experimental Asthma
Gabriele Grünig,Martha L. Warnock,Adil E. Wakil,Rajeev Venkayya,Frank Brombacher,Donna M. Rennick,Dean Sheppard,Markus Mohrs,Debra D. Donaldson,Richard M. Locksley,David B. Corry +10 more
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