Open AccessJournal Article
Interleukin-13: Central mediator of allergic asthma
Marsha Wills-Karp,Jackie Luyimbazi,Xueying Xu,Brian Schofield,Tamlyn Neben,Christopher L. Karp,Debra D. Donaldson +6 more
TLDR
In this article, the type 2 cytokine IL-13, which shares a receptor component and signaling pathways with IL-4, was found to be necessary and sufficient for the expression of allergic asthma.Abstract:
The worldwide incidence, morbidity, and mortality of allergic asthma are increasing. The pathophysiological features of allergic asthma are thought to result from the aberrant expansion of CD4 + T cells producing the type 2 cytokines interleukin-4 (IL-4) and IL-5, although a necessary role for these cytokines in allergic asthma has not been demonstrable. The type 2 cytokine IL-13, which shares a receptor component and signaling pathways with IL-4, was found to be necessary and sufficient for the expression of allergic asthma. IL-13 induces the pathophysiological features of asthma in a manner that is independent of immunoglobulin E and eosinophils. Thus, IL-13 is critical to allergen-induced asthma but operates through mechanisms other than those that are classically implicated in allergic responses.read more
Citations
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Journal ArticleDOI
Enhanced airway Th2 response after allergen challenge in mice deficient in CC chemokine receptor-2 (CCR2).
YongBok Kim,Sung-sang J. Sung,William A. Kuziel,Sanford H. Feldman,Shu Man Fu,C. Edward Rose +5 more
TL;DR: An enhanced response in airway reactivity and in lung inflammation in CCR2−/− mutant mice compared with comparably sensitized and challenged C CR2+/+ mice is demonstrated, suggesting that CC chemokines and their receptors are involved in immunomodulation of atopic asthma.
Journal ArticleDOI
Interleukin-13 gene polymorphism G4257A is associated with atopic dermatitis in Japanese patients
Yuichiro Tsunemi,Hidehisa Saeki,Koichiro Nakamura,Takashi Sekiya,Koichi Hirai,Takashi Kakinuma,Hideki Fujita,Noriko Asano,Yuka Tanida,Motoshi Wakugawa,Hideshi Torii,Kunihiko Tamaki +11 more
TL;DR: The result suggests that 4257A allele is associated with susceptibility to AD and that it may function in the pathogenesis of AD itself, presumably by other mechanisms than inducing IgE production.
Journal ArticleDOI
Interleukin-13 Gene Expression Is Regulated by GATA-3 in T Cells: ROLE OF A CRITICAL ASSOCIATION OF A GATA AND TWO GATG MOTIFS *
TL;DR: An important role of GATA-3 in CD8 cytokine gene expression is indicated and it is demonstrated that a critical network of GATG binding sites highly modulates Gata-3 activity.
Journal ArticleDOI
Both stat5a and stat5b are required for antigen-induced eosinophil and T-cell recruitment into the tissue.
Shin-ichiro Kagami,Hiroshi Nakajima,Kotaro Kumano,Kotaro Suzuki,Akira Suto,Kazunori Imada,Helen W. Davey,Yasushi Saito,Kiyoshi Takatsu,Warren J. Leonard,Itsuo Iwamoto +10 more
TL;DR: Results indicate that both Stat5a and Stat5b are essential for induction of antigen-induced eosinophil recruitment into the airways and that the defects in antigen- induced eosInophil recruits result from both impaired IL-5 production in the airway and diminished IL- 5 responsiveness of eOSinophils.
Journal ArticleDOI
Human Airway Smooth Muscle Cells Express the High Affinity Receptor for IgE (FcεRI): A Critical Role of FcεRI in Human Airway Smooth Muscle Cell Function
Abdelilah S. Gounni,Vincent Wellemans,Jia Yang,Fabienne Bellesort,Kamrouz Kassiri,Sophie C. Gangloff,Moncef Guenounou,Andrew J. Halayko,Qutayba Hamid,Bouchaib Lamkhioued +9 more
TL;DR: A potential new and important mechanism by which activated airway smooth muscle cells may participate in airway inflammation and bronchoconstriction associated with allergic asthma is suggested.
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Journal ArticleDOI
Requirement for IL-13 Independently of IL-4 in Experimental Asthma
Gabriele Grünig,Martha L. Warnock,Adil E. Wakil,Rajeev Venkayya,Frank Brombacher,Donna M. Rennick,Dean Sheppard,Markus Mohrs,Debra D. Donaldson,Richard M. Locksley,David B. Corry +10 more
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