Open AccessJournal Article
Interleukin-13: Central mediator of allergic asthma
Marsha Wills-Karp,Jackie Luyimbazi,Xueying Xu,Brian Schofield,Tamlyn Neben,Christopher L. Karp,Debra D. Donaldson +6 more
TLDR
In this article, the type 2 cytokine IL-13, which shares a receptor component and signaling pathways with IL-4, was found to be necessary and sufficient for the expression of allergic asthma.Abstract:
The worldwide incidence, morbidity, and mortality of allergic asthma are increasing. The pathophysiological features of allergic asthma are thought to result from the aberrant expansion of CD4 + T cells producing the type 2 cytokines interleukin-4 (IL-4) and IL-5, although a necessary role for these cytokines in allergic asthma has not been demonstrable. The type 2 cytokine IL-13, which shares a receptor component and signaling pathways with IL-4, was found to be necessary and sufficient for the expression of allergic asthma. IL-13 induces the pathophysiological features of asthma in a manner that is independent of immunoglobulin E and eosinophils. Thus, IL-13 is critical to allergen-induced asthma but operates through mechanisms other than those that are classically implicated in allergic responses.read more
Citations
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Journal ArticleDOI
Inhibitory effects of astragaloside IV on ovalbumin-induced chronic experimental asthma.
Qiang DuQ. Du,Zhen ChenZ. Chen,Lin-fu ZhouL. Zhou,Qian ZhangQ. Zhang,Mao HuangM. Huang,Kai-sheng YinK. Yin +5 more
TL;DR: Significant reduction of eosinophilic airway inflammation, airway hyperresponsiveness, interleukin (IL)-4 and IL-13 levels in bronchoalveolar lavage fluid, and total immunoglobulin E levels in serum indicate that astragaloside IV may mitigate the development of characteristic features in chronic experimental asthma.
Journal ArticleDOI
IL-33-mediated IL-13 secretion by ST2+ Tregs controls inflammation after lung injury.
Quan Liu,Gaelen K. Dwyer,Yifei Zhao,Hui-Hua Li,Lisa R. Mathews,Anish Chakka,Uma R. Chandran,J. Demetris,John F. Alcorn,Keven M. Robinson,Luis A. Ortiz,Bruce R. Pitt,Angus W. Thomson,Ming-Hui Fan,Timothy R. Billiar,Heth R. Turnquist +15 more
TL;DR: This study identifies a regulatory mechanism involving IL-33 and Treg secretion of IL-13 in response to tissue damage that is instrumental in limiting local inflammatory responses and may shape the myeloid compartment after lung injury.
Journal ArticleDOI
Personalized medicine with biologics for severe type 2 asthma: current status and future prospects
TL;DR: Biologics targeting type 2 cytokines have shown consistent efficacy, especially in patients with evidence of type 2 inflammation, suggesting that the future of asthma biologics is promising.
Journal ArticleDOI
IL-11 Selectively Inhibits Aeroallergen-Induced Pulmonary Eosinophilia and Th2 Cytokine Production
Jingming Wang,Robert J. Homer,Lielie Hong,Lauren Cohn,Chun Guen Lee,Sungsoo Jung,Jack A. Elias +6 more
TL;DR: It is demonstrated that IL-11 selectively inhibits Ag-induced eosinophilia, Th2 inflammation, and VCAM-1 gene expression in pulmonary tissues.
Journal ArticleDOI
Ocular surface and MUC5AC alterations in atopic patients with corneal shield ulcers.
Murat Dogru,Naoko Asano-Kato,Mari Tanaka,Ayako Igarashi,Shigeto Shimmura,Jun Shimazaki,Naoko Okada,Yoji Takano,Kazumi Fukagawa,Kazuo Tsubota,Hiroshi Fujishima +10 more
TL;DR: Ocular surface inflammation, tear film instability, and decreased conjunctival MUC5AC mRNA expression were thought to be important in the pathogenesis of noninfectious corneal shield ulcers in atopic ocular surface disease.
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Douglas S. Robinson,Qutayba Hamid,Sun Ying,Anne Tsicopoulos,J. Barkans,Andrew Bentley,Christopher Corrigan,Stephen R. Durham,A. B. Kay +8 more
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Eosinophilic inflammation in asthma.
Jean Bousquet,Pascal Chanez,J.-Y. Lacoste,G. Barneon,N Ghavanian,I. Enander,Per Venge,Staffan Ahlstedt,J Simony-Lafontaine,P. Godard +9 more
TL;DR: Eosinophilic inflammation of the airways is correlated with the severity of asthma and these cells are likely to play a part in the epithelial damage seen in this disease.
Journal ArticleDOI
Requirement for IL-13 Independently of IL-4 in Experimental Asthma
Gabriele Grünig,Martha L. Warnock,Adil E. Wakil,Rajeev Venkayya,Frank Brombacher,Donna M. Rennick,Dean Sheppard,Markus Mohrs,Debra D. Donaldson,Richard M. Locksley,David B. Corry +10 more
TL;DR: This article showed that IL-4 receptor α chain-dependent pathway may underlie the genetic associations of asthma with both the human 5q31 locus and the IL4 receptor and showed that selective neutralization of IL-13, a cytokine related to interleukin-4 that also binds to the α chain of the IL 4 receptor, ameliorated asthma phenotype.
Journal ArticleDOI
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