Open AccessJournal Article
Interleukin-13: Central mediator of allergic asthma
Marsha Wills-Karp,Jackie Luyimbazi,Xueying Xu,Brian Schofield,Tamlyn Neben,Christopher L. Karp,Debra D. Donaldson +6 more
TLDR
In this article, the type 2 cytokine IL-13, which shares a receptor component and signaling pathways with IL-4, was found to be necessary and sufficient for the expression of allergic asthma.Abstract:
The worldwide incidence, morbidity, and mortality of allergic asthma are increasing. The pathophysiological features of allergic asthma are thought to result from the aberrant expansion of CD4 + T cells producing the type 2 cytokines interleukin-4 (IL-4) and IL-5, although a necessary role for these cytokines in allergic asthma has not been demonstrable. The type 2 cytokine IL-13, which shares a receptor component and signaling pathways with IL-4, was found to be necessary and sufficient for the expression of allergic asthma. IL-13 induces the pathophysiological features of asthma in a manner that is independent of immunoglobulin E and eosinophils. Thus, IL-13 is critical to allergen-induced asthma but operates through mechanisms other than those that are classically implicated in allergic responses.read more
Citations
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Book ChapterDOI
Regulation of IL-4 Expression in Immunity and Diseases.
I-Cheng Ho,Shi-Chuen Miaw +1 more
TL;DR: This chapter will review in detail the molecular mechanism regulating the cell type-specific expression of IL-4 in physiological and pathological type 2 immune responses.
Journal ArticleDOI
Targeting IL-4/IL-13 signaling to alleviate oral allergen–induced diarrhea
Eric B. Brandt,Ariel Munitz,Tatyana Orekov,Melissa K. Mingler,Melissa McBride,Fred D. Finkelman,Fred D. Finkelman,Marc E. Rothenberg +7 more
TL;DR: Endogenously produced IL-13 supplements the ability of IL-4 to induce allergic diarrhea by promoting oral allergen sensitization rather than the effector phase of intestinal anaphylaxis.
Journal ArticleDOI
An open-label, single-dose bioavailability study of the pharmacokinetics of CAT-354 after subcutaneous and intravenous administration in healthy males
Chad K. Oh,Raffaella Faggioni,Feng Jin,Lorin Roskos,Bing Wang,Claire Birrell,Rosamund Wilson,Nestor A. Molfino +7 more
TL;DR: CAT-354 exhibited bioavailability of approximately 60% when given s.c. to healthy male subjects, and dosing was consistent with endogenous IgG and reticuloendothelial elimination.
Journal ArticleDOI
Mycoplasma pneumoniae induces host-dependent pulmonary inflammation and airway obstruction in mice.
Monica Fonseca-Aten,Ana María Ríos,Asuncion Mejias,Susana Chavez-Bueno,Kathy Katz,Ana M. Gomez,George H. McCracken,R. Doug Hardy +7 more
TL;DR: The mice in this study exhibited host-dependent infection-related AO and AHR associated with chemokine and T-helper type (Th)1 pulmonary host response and not Th2 response after M. pneumoniae infection.
Journal ArticleDOI
Eosinophil trafficking in asthma.
TL;DR: The implications of this multistep process are that antagonists of IL-5, VLA-4, PSGL-1 and CC chemokine receptor 3, as well as IL-4 and IL-13, each have the potential markedly to inhibit eosinophil recruitment in asthma.
References
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Jean Bousquet,Pascal Chanez,J.-Y. Lacoste,G. Barneon,N Ghavanian,I. Enander,Per Venge,Staffan Ahlstedt,J Simony-Lafontaine,P. Godard +9 more
TL;DR: Eosinophilic inflammation of the airways is correlated with the severity of asthma and these cells are likely to play a part in the epithelial damage seen in this disease.
Journal ArticleDOI
Requirement for IL-13 Independently of IL-4 in Experimental Asthma
Gabriele Grünig,Martha L. Warnock,Adil E. Wakil,Rajeev Venkayya,Frank Brombacher,Donna M. Rennick,Dean Sheppard,Markus Mohrs,Debra D. Donaldson,Richard M. Locksley,David B. Corry +10 more
TL;DR: This article showed that IL-4 receptor α chain-dependent pathway may underlie the genetic associations of asthma with both the human 5q31 locus and the IL4 receptor and showed that selective neutralization of IL-13, a cytokine related to interleukin-4 that also binds to the α chain of the IL 4 receptor, ameliorated asthma phenotype.
Journal ArticleDOI
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