Open AccessJournal Article
Interleukin-13: Central mediator of allergic asthma
Marsha Wills-Karp,Jackie Luyimbazi,Xueying Xu,Brian Schofield,Tamlyn Neben,Christopher L. Karp,Debra D. Donaldson +6 more
TLDR
In this article, the type 2 cytokine IL-13, which shares a receptor component and signaling pathways with IL-4, was found to be necessary and sufficient for the expression of allergic asthma.Abstract:
The worldwide incidence, morbidity, and mortality of allergic asthma are increasing. The pathophysiological features of allergic asthma are thought to result from the aberrant expansion of CD4 + T cells producing the type 2 cytokines interleukin-4 (IL-4) and IL-5, although a necessary role for these cytokines in allergic asthma has not been demonstrable. The type 2 cytokine IL-13, which shares a receptor component and signaling pathways with IL-4, was found to be necessary and sufficient for the expression of allergic asthma. IL-13 induces the pathophysiological features of asthma in a manner that is independent of immunoglobulin E and eosinophils. Thus, IL-13 is critical to allergen-induced asthma but operates through mechanisms other than those that are classically implicated in allergic responses.read more
Citations
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Signal transducer and activator of transcription 6 (STAT-6) expression and function in asthmatic bronchial epithelium.
Rebecca E. Mullings,Susan J. Wilson,Susan J. Wilson,Sarah M. Puddicombe,Sarah M. Puddicombe,James L. Lordan,James L. Lordan,Fabio Bucchieri,Fabio Bucchieri,Ratko Djukanovic,Ratko Djukanovic,Peter H. Howarth,Peter H. Howarth,Steven Harper,Steven Harper,Stephen T. Holgate,Stephen T. Holgate,Donna E. Davies,Donna E. Davies +18 more
TL;DR: The activity of this transcription factor is likely to play a key role in mediating the responses of the bronchial epithelium to T(H)2 cytokines that are characteristic of the asthmatic phenotype.
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Effect of tiotropium bromide on airway inflammation and remodelling in a mouse model of asthma
Sei Ohta,Naruhito Oda,Takuya Yokoe,Akihiko Tanaka,Yoshitaka Yamamoto,Yurie Watanabe,Kenji Minoguchi,Tsukasa Ohnishi,Takashi Hirose,Hiroyuki Nagase,Ken Ohta,Mitsuru Adachi +11 more
TL;DR: Tiotropium bromide, a long acting muscarinic receptor inhibitor, is a potent agent for patients with bronchial asthma as well as chronic obstructive pulmonary disease.
Journal ArticleDOI
The R576 IL-4 receptor α allele correlates with asthma severity☆☆☆★
Lillian Rosa-Rosa,Nives Zimmermann,Jonathan A. Bernstein,Marc E. Rothenberg,Gurjit K. Khurana Hershey +4 more
TL;DR: R576IL-4Rα acts as an allergic asthma susceptibility and disease-modifying gene and may serve as a clinically useful marker of asthma severity, suggesting a gene dosage effect.
Journal ArticleDOI
The E3 ubiquitin ligase midline 1 promotes allergen and rhinovirus-induced asthma by inhibiting protein phosphatase 2A activity
Adam Collison,Luke Hatchwell,Nicole M. Verrills,Peter A. B. Wark,Peter A. B. Wark,Ana Pereira de Siqueira,Melinda Tooze,Melinda Tooze,Helen Carpenter,Anthony S. Don,Jonathan C. Morris,Nives Zimmermann,Nathan W. Bartlett,Marc E. Rothenberg,Sebastian L. Johnston,Paul S. Foster,Joerg Mattes,Joerg Mattes +17 more
TL;DR: It is found that MID1 was upregulated in primary human bronchial epithelial cells upon HDM or rhinovirus exposure, and this correlated with TRAIL and CCL20 expression.
Journal ArticleDOI
Animal models of asthma: value, limitations and opportunities for alternative approaches
TL;DR: A disease modelling framework designed to better understand human asthma, and accelerate the development of safe and efficacious new asthma drugs that go beyond symptomatic relief is suggested.
References
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Journal ArticleDOI
Functional diversity of helper T lymphocytes.
TL;DR: The existence of subsets of CD4+ helper T lymphocytes that differ in their cytokine secretion patterns and effector functions provides a framework for understanding the heterogeneity of normal and pathological immune responses.
Journal ArticleDOI
Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma
Douglas S. Robinson,Qutayba Hamid,Sun Ying,Anne Tsicopoulos,J. Barkans,Andrew Bentley,Christopher Corrigan,Stephen R. Durham,A. B. Kay +8 more
TL;DR: Atopic asthma is associated with activation in the bronchi of the interleukin-3, 4, and 5 and GM-CSF gene cluster, a pattern compatible with predominant activation of the TH2-like T-cell population.
Journal ArticleDOI
Eosinophilic inflammation in asthma.
Jean Bousquet,Pascal Chanez,J.-Y. Lacoste,G. Barneon,N Ghavanian,I. Enander,Per Venge,Staffan Ahlstedt,J Simony-Lafontaine,P. Godard +9 more
TL;DR: Eosinophilic inflammation of the airways is correlated with the severity of asthma and these cells are likely to play a part in the epithelial damage seen in this disease.
Journal ArticleDOI
Requirement for IL-13 Independently of IL-4 in Experimental Asthma
Gabriele Grünig,Martha L. Warnock,Adil E. Wakil,Rajeev Venkayya,Frank Brombacher,Donna M. Rennick,Dean Sheppard,Markus Mohrs,Debra D. Donaldson,Richard M. Locksley,David B. Corry +10 more
TL;DR: This article showed that IL-4 receptor α chain-dependent pathway may underlie the genetic associations of asthma with both the human 5q31 locus and the IL4 receptor and showed that selective neutralization of IL-13, a cytokine related to interleukin-4 that also binds to the α chain of the IL 4 receptor, ameliorated asthma phenotype.
Journal ArticleDOI
Cellular events in the bronchi in mild asthma and after bronchial provocation.
TL;DR: It is concluded that allergic asthma is accompanied by extensive inflammatory changes in the airways, even in mild clinical and subclinical disease.
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