Open AccessJournal Article
Interleukin-13: Central mediator of allergic asthma
Marsha Wills-Karp,Jackie Luyimbazi,Xueying Xu,Brian Schofield,Tamlyn Neben,Christopher L. Karp,Debra D. Donaldson +6 more
TLDR
In this article, the type 2 cytokine IL-13, which shares a receptor component and signaling pathways with IL-4, was found to be necessary and sufficient for the expression of allergic asthma.Abstract:
The worldwide incidence, morbidity, and mortality of allergic asthma are increasing. The pathophysiological features of allergic asthma are thought to result from the aberrant expansion of CD4 + T cells producing the type 2 cytokines interleukin-4 (IL-4) and IL-5, although a necessary role for these cytokines in allergic asthma has not been demonstrable. The type 2 cytokine IL-13, which shares a receptor component and signaling pathways with IL-4, was found to be necessary and sufficient for the expression of allergic asthma. IL-13 induces the pathophysiological features of asthma in a manner that is independent of immunoglobulin E and eosinophils. Thus, IL-13 is critical to allergen-induced asthma but operates through mechanisms other than those that are classically implicated in allergic responses.read more
Citations
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Journal ArticleDOI
Transgenic modeling of interleukin-13 in the lung.
Jack A. Elias,Tao Zheng,Chun Geun Lee,Robert J. Homer,Qingsheng Chen,Bing Ma,Michael R. Blackburn,Zhou Zhu +7 more
TL;DR: It was demonstrated that chemokine receptor-2, transforming growth factor-beta(1), and IL-11 play an important role in the regulation of inflammation and remodeling in the IL-13-treated lung and validated in vivo genetic targets against which therapies can be directed to selectively regulate aspects of theIL-13 phenotype.
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Resolution of inflammation in asthma.
TL;DR: This article focuses on recent discoveries of natural mediators derived from essential fatty acids, including ω-3 fatty acid, with anti-inflammatory and pro-resolving properties, which serve as agonists at specific receptors.
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Viral infections, cytokine dysregulation and the origins of childhood asthma and allergic diseases.
Samuel L. Friedlander,Daniel J. Jackson,Ronald E. Gangnon,Michael D. Evans,Zhanhai Li,Kathy A. Roberg,Elizabeth L. Anderson,Kirstin T Carlson-Dakes,Kiva J. Adler,Stephanie Gilbertson-White,Tressa Pappas,Douglas F. DaSilva,Christopher J. Tisler,Lisa E. Pleiss,Lance D. Mikus,Louis A. Rosenthal,Peter Shult,Carol J. Kirk,Erik Reisdorf,Sabine Hoffjan,James E. Gern,Robert F. Lemanske +21 more
TL;DR: The Childhood Origins of Asthma project evaluated children at high risk for asthma to study the relationships among viral infections, environmental factors, immune dysregulation, genetic factors, and the development of atopic diseases as discussed by the authors.
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A Cell-Impermeable Cyclosporine A Derivative Reduces Pathology in a Mouse Model of Allergic Lung Inflammation
Molly A. Balsley,Miroslav Malesevic,Erik J. Stemmy,Jason P. Gigley,Rosalyn A. Jurjus,Dallen Herzog,Michael Bukrinsky,Gunter Fischer,Stephanie L. Constant +8 more
TL;DR: Treatment with this compound in a mouse model of allergic lung inflammation demonstrates up to 80% reduction in inflammation, directly inhibits the recruitment of Ag-specific CD4+ T cells, and works equally well when delivered at 100-fold lower doses directly to the airways.
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Emerging immune targets for the therapy of allergic asthma.
TL;DR: This review explores the latest advances in the understanding of the pathogenesis of allergic asthma, and provides insight into the expanding collaborations between research scientists, clinicians and the pharmaceutical industry in the race to control the asthma epidemic.
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Journal ArticleDOI
Eosinophilic inflammation in asthma.
Jean Bousquet,Pascal Chanez,J.-Y. Lacoste,G. Barneon,N Ghavanian,I. Enander,Per Venge,Staffan Ahlstedt,J Simony-Lafontaine,P. Godard +9 more
TL;DR: Eosinophilic inflammation of the airways is correlated with the severity of asthma and these cells are likely to play a part in the epithelial damage seen in this disease.
Journal ArticleDOI
Requirement for IL-13 Independently of IL-4 in Experimental Asthma
Gabriele Grünig,Martha L. Warnock,Adil E. Wakil,Rajeev Venkayya,Frank Brombacher,Donna M. Rennick,Dean Sheppard,Markus Mohrs,Debra D. Donaldson,Richard M. Locksley,David B. Corry +10 more
TL;DR: This article showed that IL-4 receptor α chain-dependent pathway may underlie the genetic associations of asthma with both the human 5q31 locus and the IL4 receptor and showed that selective neutralization of IL-13, a cytokine related to interleukin-4 that also binds to the α chain of the IL 4 receptor, ameliorated asthma phenotype.
Journal ArticleDOI
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