Open AccessJournal Article
Interleukin-13: Central mediator of allergic asthma
Marsha Wills-Karp,Jackie Luyimbazi,Xueying Xu,Brian Schofield,Tamlyn Neben,Christopher L. Karp,Debra D. Donaldson +6 more
TLDR
In this article, the type 2 cytokine IL-13, which shares a receptor component and signaling pathways with IL-4, was found to be necessary and sufficient for the expression of allergic asthma.Abstract:
The worldwide incidence, morbidity, and mortality of allergic asthma are increasing. The pathophysiological features of allergic asthma are thought to result from the aberrant expansion of CD4 + T cells producing the type 2 cytokines interleukin-4 (IL-4) and IL-5, although a necessary role for these cytokines in allergic asthma has not been demonstrable. The type 2 cytokine IL-13, which shares a receptor component and signaling pathways with IL-4, was found to be necessary and sufficient for the expression of allergic asthma. IL-13 induces the pathophysiological features of asthma in a manner that is independent of immunoglobulin E and eosinophils. Thus, IL-13 is critical to allergen-induced asthma but operates through mechanisms other than those that are classically implicated in allergic responses.read more
Citations
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Journal ArticleDOI
Agents against cytokine synthesis or receptors.
TL;DR: As many cytokines are involved in the pathophysiology of inflammatory lung diseases, inhibitory agents of the synthesis of multiple cytokines may be more useful tools and several such agents are now in clinical development.
Journal ArticleDOI
Origin, Localization, and Immunoregulatory Properties of Pulmonary Phagocytes in Allergic Asthma.
Franziska M. Hoffmann,Fanny Ender,Inken Schmudde,Ian P. Lewkowich,Jörg Köhl,Peter König,Yves Laumonnier +6 more
TL;DR: An update on the current understanding of the origin, localization, and function of the diverse pulmonary antigen-presenting cell subsets, in particular with regard to the development and regulation of allergic asthma is provided.
Journal ArticleDOI
deltaNp63 has a role in maintaining epithelial integrity in airway epithelium.
Ari Jon Arason,Hulda R. Jonsdottir,Skarphedinn Halldorsson,Berglind Eva Benediktsdóttir,Jon Thor Bergthorsson,Saevar Ingthorsson,Olafur Baldursson,Satrajit Sinha,Thorarinn Gudjonsson,Magnus K. Magnusson +9 more
TL;DR: It is demonstrated that ΔNp63 is the major isoform in the human lung and its expression was exclusively found in the basal cells lining the basement membrane of the bronchial epithelium.
Journal ArticleDOI
Interleukin-13-dependent expression of matrix metalloproteinase-12 is required for the development of airway eosinophilia in mice.
Mahmoud A. Pouladi,Clinton S. Robbins,Filip K. Swirski,Meghan Cundall,Andrew N. J. McKenzie,Manel Jordana,Steven D. Shapiro,Martin R. Stämpfli +7 more
TL;DR: Data indicate a novel function for MMP-12 in the process of airway eosinophil accumulation in the context of adenovirus-mediated granulocyte macrophage colony-stimulating factor expression.
Journal ArticleDOI
Characterization of a powerful high affinity antagonist that inhibits biological activities of human interleukin-13.
Yasuo Oshima,Raj K. Puri +1 more
TL;DR: It is demonstrated that high affinity binding and signal generation can be uncoupled efficiently in a ligand receptor interaction and suggested that IL-13E13K may be a useful antagonist for the treatment of allergic, inflammatory, and parasitic diseases or even malignancies in which IL- 13 plays a central role.
References
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Douglas S. Robinson,Qutayba Hamid,Sun Ying,Anne Tsicopoulos,J. Barkans,Andrew Bentley,Christopher Corrigan,Stephen R. Durham,A. B. Kay +8 more
TL;DR: Atopic asthma is associated with activation in the bronchi of the interleukin-3, 4, and 5 and GM-CSF gene cluster, a pattern compatible with predominant activation of the TH2-like T-cell population.
Journal ArticleDOI
Eosinophilic inflammation in asthma.
Jean Bousquet,Pascal Chanez,J.-Y. Lacoste,G. Barneon,N Ghavanian,I. Enander,Per Venge,Staffan Ahlstedt,J Simony-Lafontaine,P. Godard +9 more
TL;DR: Eosinophilic inflammation of the airways is correlated with the severity of asthma and these cells are likely to play a part in the epithelial damage seen in this disease.
Journal ArticleDOI
Requirement for IL-13 Independently of IL-4 in Experimental Asthma
Gabriele Grünig,Martha L. Warnock,Adil E. Wakil,Rajeev Venkayya,Frank Brombacher,Donna M. Rennick,Dean Sheppard,Markus Mohrs,Debra D. Donaldson,Richard M. Locksley,David B. Corry +10 more
TL;DR: This article showed that IL-4 receptor α chain-dependent pathway may underlie the genetic associations of asthma with both the human 5q31 locus and the IL4 receptor and showed that selective neutralization of IL-13, a cytokine related to interleukin-4 that also binds to the α chain of the IL 4 receptor, ameliorated asthma phenotype.
Journal ArticleDOI
Cellular events in the bronchi in mild asthma and after bronchial provocation.
TL;DR: It is concluded that allergic asthma is accompanied by extensive inflammatory changes in the airways, even in mild clinical and subclinical disease.
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