Open AccessJournal Article
Interleukin-13: Central mediator of allergic asthma
Marsha Wills-Karp,Jackie Luyimbazi,Xueying Xu,Brian Schofield,Tamlyn Neben,Christopher L. Karp,Debra D. Donaldson +6 more
TLDR
In this article, the type 2 cytokine IL-13, which shares a receptor component and signaling pathways with IL-4, was found to be necessary and sufficient for the expression of allergic asthma.Abstract:
The worldwide incidence, morbidity, and mortality of allergic asthma are increasing. The pathophysiological features of allergic asthma are thought to result from the aberrant expansion of CD4 + T cells producing the type 2 cytokines interleukin-4 (IL-4) and IL-5, although a necessary role for these cytokines in allergic asthma has not been demonstrable. The type 2 cytokine IL-13, which shares a receptor component and signaling pathways with IL-4, was found to be necessary and sufficient for the expression of allergic asthma. IL-13 induces the pathophysiological features of asthma in a manner that is independent of immunoglobulin E and eosinophils. Thus, IL-13 is critical to allergen-induced asthma but operates through mechanisms other than those that are classically implicated in allergic responses.read more
Citations
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A phase II placebo-controlled study of tralokinumab in moderate-to-severe asthma
Edward Piper,Christopher E. Brightling,Robert Niven,Chad K. Oh,Raffaella Faggioni,Kwai Poon,Dewei She,Chris Kell,Richard D. May,Gregory P. Geba,Nestor A. Molfino +10 more
TL;DR: The effects of tralokinumab, an investigational human IL-13-neutralising immunoglobulin G4 monoclonal antibody, in adults with moderate-to-severe uncontrolled asthma despite controller therapies was assessed, although no improvement in ACQ-6 was observed, although tralokerumab treatment was associated with improved lung function.
Journal ArticleDOI
Taking our breath away: dendritic cells in the pathogenesis of asthma.
Bart N. Lambrecht,Hamida Hammad +1 more
TL;DR: It is proposed that DCs are similarly essential for controlling effector T-cell responses and, therefore, might have a role in T- cell-mediated diseases.
Journal ArticleDOI
Defective lipoxin-mediated anti-inflammatory activity in the cystic fibrosis airway.
Christopher L. Karp,Leah M. Flick,Kiwon Park,Samir Softic,Todd M. Greer,Raquel Keledjian,Rong Yang,Jasmin Uddin,William B. Guggino,Sowsan F. Atabani,Yasmine Belkaid,Yan Xu,Jeffrey A. Whitsett,Frank J. Accurso,Marsha Wills-Karp,Nicos A. Petasis +15 more
TL;DR: It is reported here that lipoxin concentrations in airway fluid were significantly suppressed in patients with cystic fibrosis compared to patients with other inflammatory lung conditions and that lipoxins have therapeutic potential in this lethal autosomal disease.
Journal ArticleDOI
Protectin D1 Is Generated in Asthma and Dampens Airway Inflammation and Hyperresponsiveness
Bruce D. Levy,Payal Kohli,Katherine H. Gotlinger,Oliver Haworth,Song Hong,Shamsah Kazani,Elliot Israel,Kathleen J. Haley,Charles N. Serhan +8 more
TL;DR: Findings provide evidence for endogenous PD1 as a pivotal counterregulatory signal in allergic airway inflammation and point to new therapeutic strategies for modulating inflammation in asthmatic lung.
Journal ArticleDOI
IL-4 and IL-13 signaling in allergic airway disease.
Naina Gour,Marsha Wills-Karp +1 more
TL;DR: The purpose of this chapter is to review the current understanding of the distinct roles that IL-4 and IL-13 play in allergic inflammatory states and the utility of their modulation as potential therapeutic strategies for the treatment of allergic disorders.
References
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Jean Bousquet,Pascal Chanez,J.-Y. Lacoste,G. Barneon,N Ghavanian,I. Enander,Per Venge,Staffan Ahlstedt,J Simony-Lafontaine,P. Godard +9 more
TL;DR: Eosinophilic inflammation of the airways is correlated with the severity of asthma and these cells are likely to play a part in the epithelial damage seen in this disease.
Journal ArticleDOI
Requirement for IL-13 Independently of IL-4 in Experimental Asthma
Gabriele Grünig,Martha L. Warnock,Adil E. Wakil,Rajeev Venkayya,Frank Brombacher,Donna M. Rennick,Dean Sheppard,Markus Mohrs,Debra D. Donaldson,Richard M. Locksley,David B. Corry +10 more
TL;DR: This article showed that IL-4 receptor α chain-dependent pathway may underlie the genetic associations of asthma with both the human 5q31 locus and the IL4 receptor and showed that selective neutralization of IL-13, a cytokine related to interleukin-4 that also binds to the α chain of the IL 4 receptor, ameliorated asthma phenotype.
Journal ArticleDOI
Cellular events in the bronchi in mild asthma and after bronchial provocation.
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