Open AccessJournal Article
Interleukin-13: Central mediator of allergic asthma
Marsha Wills-Karp,Jackie Luyimbazi,Xueying Xu,Brian Schofield,Tamlyn Neben,Christopher L. Karp,Debra D. Donaldson +6 more
TLDR
In this article, the type 2 cytokine IL-13, which shares a receptor component and signaling pathways with IL-4, was found to be necessary and sufficient for the expression of allergic asthma.Abstract:
The worldwide incidence, morbidity, and mortality of allergic asthma are increasing. The pathophysiological features of allergic asthma are thought to result from the aberrant expansion of CD4 + T cells producing the type 2 cytokines interleukin-4 (IL-4) and IL-5, although a necessary role for these cytokines in allergic asthma has not been demonstrable. The type 2 cytokine IL-13, which shares a receptor component and signaling pathways with IL-4, was found to be necessary and sufficient for the expression of allergic asthma. IL-13 induces the pathophysiological features of asthma in a manner that is independent of immunoglobulin E and eosinophils. Thus, IL-13 is critical to allergen-induced asthma but operates through mechanisms other than those that are classically implicated in allergic responses.read more
Citations
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Journal ArticleDOI
Notch signaling prevents mucous metaplasia in mouse conducting airways during postnatal development
Po-Nien Tsao,Shu-Chen Wei,Ming-Fang Wu,Miao-Tzu Huang,Hsien-Yi Lin,Ming-Cheng Lee,Kurt M. Lin,I-Jong Wang,Vesa Kaartinen,Liang-Tung Yang,Wellington V. Cardoso +10 more
TL;DR: Evidence is provided of a novel role for Notch in restricting goblet cell differentiation in the airway epithelium during the postnatal period and Luciferase reporter analysis suggested that Notch directly repressed MUC5AC transcription in lung epithelial cells.
Journal ArticleDOI
Interleukin-18 enhances antigen-induced eosinophil recruitment into the mouse airways.
Kotaro Kumano,Atsuhito Nakao,Hiroshi Nakajima,Fumiaki Hayashi,Masashi Kurimoto,Haruki Okamura,Yasushi Saito,Itsuo Iwamoto +7 more
TL;DR: It is shown that the administration of recombinant murine IL-18 enhanced antigen-induced eosinophil recruitment into the trachea and bronchoalveolar lavage fluids of sensitized mice in a dose-dependent manner, and that IL- 18 may contribute to the development and exacerbation of airway inflammation in asthma.
Journal ArticleDOI
Analysis of the 5q31-q33 locus shows an association between IL13-1055C/T IL-13-591A/G polymorphisms and Schistosoma haematobium infections.
Bourema Kouriba,Christophe Chevillard,Christophe Chevillard,Jay H. Bream,Laurent Argiro,Hélia Dessein,Violaine Arnaud,Lansana Sangaré,Abdoulaye Dabo,Abdou Habib Beavogui,Charles Arama,Hamar A. Traoré,Ogobara K. Doumbo,Alain Dessein +13 more
TL;DR: It is shown that subjects bearing the IL13-1055T/T genotype were on average much less infected than individuals with other genotypes, which is in agreement with the fact that this cytokine enhances resistance to infection by schistosome in humans.
Journal Article
Interleukin-13 receptor-targeted cancer therapy in an immunodeficient animal model of human head and neck cancer.
TL;DR: The results demonstrate that by using a combination approach of gene transfer and systemic or locoregional cytotoxin therapy, the IL-13R represents a new potent target for head and neck cancer therapy.
Journal ArticleDOI
IL-13 signal transduction in human monocytes: phosphorylation of receptor components, association with Jaks, and phosphorylation/activation of Stats
TL;DR: The first complete report of the functional IL‐13 receptor complex and early signaling events in human monocytes is identified and it is reported that Jak2 is associated with IL‐4Rα, and Tyk2 isassociated with theIL‐13Rα1 component of the IL‐ 13 receptor complex.
References
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Journal ArticleDOI
Eosinophilic inflammation in asthma.
Jean Bousquet,Pascal Chanez,J.-Y. Lacoste,G. Barneon,N Ghavanian,I. Enander,Per Venge,Staffan Ahlstedt,J Simony-Lafontaine,P. Godard +9 more
TL;DR: Eosinophilic inflammation of the airways is correlated with the severity of asthma and these cells are likely to play a part in the epithelial damage seen in this disease.
Journal ArticleDOI
Requirement for IL-13 Independently of IL-4 in Experimental Asthma
Gabriele Grünig,Martha L. Warnock,Adil E. Wakil,Rajeev Venkayya,Frank Brombacher,Donna M. Rennick,Dean Sheppard,Markus Mohrs,Debra D. Donaldson,Richard M. Locksley,David B. Corry +10 more
TL;DR: This article showed that IL-4 receptor α chain-dependent pathway may underlie the genetic associations of asthma with both the human 5q31 locus and the IL4 receptor and showed that selective neutralization of IL-13, a cytokine related to interleukin-4 that also binds to the α chain of the IL 4 receptor, ameliorated asthma phenotype.
Journal ArticleDOI
Cellular events in the bronchi in mild asthma and after bronchial provocation.
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