Open AccessJournal Article
Interleukin-13: Central mediator of allergic asthma
Marsha Wills-Karp,Jackie Luyimbazi,Xueying Xu,Brian Schofield,Tamlyn Neben,Christopher L. Karp,Debra D. Donaldson +6 more
TLDR
In this article, the type 2 cytokine IL-13, which shares a receptor component and signaling pathways with IL-4, was found to be necessary and sufficient for the expression of allergic asthma.Abstract:
The worldwide incidence, morbidity, and mortality of allergic asthma are increasing. The pathophysiological features of allergic asthma are thought to result from the aberrant expansion of CD4 + T cells producing the type 2 cytokines interleukin-4 (IL-4) and IL-5, although a necessary role for these cytokines in allergic asthma has not been demonstrable. The type 2 cytokine IL-13, which shares a receptor component and signaling pathways with IL-4, was found to be necessary and sufficient for the expression of allergic asthma. IL-13 induces the pathophysiological features of asthma in a manner that is independent of immunoglobulin E and eosinophils. Thus, IL-13 is critical to allergen-induced asthma but operates through mechanisms other than those that are classically implicated in allergic responses.read more
Citations
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Journal ArticleDOI
A defective type 1 response to rhinovirus in atopic asthma
Nikolaos G. Papadopoulos,Luminita A. Stanciu,Alberto Papi,Stephen T. Holgate,Sebastian L. Johnston +4 more
TL;DR: Evidence suggests that the immune response to RVs is not uniquely of a type 1 phenotype, as previously suggested, and the type 1 response is defective in atopic asthmatic individuals, with a shift towards a type 2 phenotype.
Journal ArticleDOI
IL-13 in asthma and allergic disease: asthma phenotypes and targeted therapies.
Jennifer L. Ingram,Monica Kraft +1 more
TL;DR: Researchers and clinicians can now evaluate biomarkers of T(H)2-driven airway inflammation in asthmatic patients, such as serum IgE levels, sputum eosinophil counts, fraction of exhaled nitric oxide levels, and serum periostin levels, to aid decision making in clinical trials and drug development and to identify subsets of patients who might benefit from therapies.
Journal ArticleDOI
Therapeutic strategies for allergic diseases
TL;DR: Most of the many new therapies in development are aimed at inhibiting components of the allergic inflammatory response, but in the future there are real possibilities for the development of preventative and even curative treatments.
Journal ArticleDOI
Molecular and cellular mechanisms of allergic disease
TL;DR: Improved understanding of the basic mechanisms of allergic inflammation has led to the discovery of molecular targets involved in the initial events of the inflammatory cascade, which potential targets for the development of novel therapies for allergic disease include IgE, the T( H)2 lymphocyte, and T(H)2-derived cytokines, IL-4 and IL-5.
Journal ArticleDOI
Inhaled Multiwalled Carbon Nanotubes Potentiate Airway Fibrosis in Murine Allergic Asthma
Jessica P. Ryman-Rasmussen,Earl W. Tewksbury,Owen R. Moss,Mark F. Cesta,Brian A. Wong,James C. Bonner +5 more
TL;DR: It is indicated that individuals with pre-existing allergic inflammation may be susceptible to airway fibrosis from inhaled multiwalled carbon nanotubes, and combined ovalbumin sensitization and MWCNT inhalation also synergistically increased IL-5 mRNA levels, which could further contribute to airways fibrosis.
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Jean Bousquet,Pascal Chanez,J.-Y. Lacoste,G. Barneon,N Ghavanian,I. Enander,Per Venge,Staffan Ahlstedt,J Simony-Lafontaine,P. Godard +9 more
TL;DR: Eosinophilic inflammation of the airways is correlated with the severity of asthma and these cells are likely to play a part in the epithelial damage seen in this disease.
Journal ArticleDOI
Requirement for IL-13 Independently of IL-4 in Experimental Asthma
Gabriele Grünig,Martha L. Warnock,Adil E. Wakil,Rajeev Venkayya,Frank Brombacher,Donna M. Rennick,Dean Sheppard,Markus Mohrs,Debra D. Donaldson,Richard M. Locksley,David B. Corry +10 more
TL;DR: This article showed that IL-4 receptor α chain-dependent pathway may underlie the genetic associations of asthma with both the human 5q31 locus and the IL4 receptor and showed that selective neutralization of IL-13, a cytokine related to interleukin-4 that also binds to the α chain of the IL 4 receptor, ameliorated asthma phenotype.
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