Open AccessJournal Article
Interleukin-13: Central mediator of allergic asthma
Marsha Wills-Karp,Jackie Luyimbazi,Xueying Xu,Brian Schofield,Tamlyn Neben,Christopher L. Karp,Debra D. Donaldson +6 more
TLDR
In this article, the type 2 cytokine IL-13, which shares a receptor component and signaling pathways with IL-4, was found to be necessary and sufficient for the expression of allergic asthma.Abstract:
The worldwide incidence, morbidity, and mortality of allergic asthma are increasing. The pathophysiological features of allergic asthma are thought to result from the aberrant expansion of CD4 + T cells producing the type 2 cytokines interleukin-4 (IL-4) and IL-5, although a necessary role for these cytokines in allergic asthma has not been demonstrable. The type 2 cytokine IL-13, which shares a receptor component and signaling pathways with IL-4, was found to be necessary and sufficient for the expression of allergic asthma. IL-13 induces the pathophysiological features of asthma in a manner that is independent of immunoglobulin E and eosinophils. Thus, IL-13 is critical to allergen-induced asthma but operates through mechanisms other than those that are classically implicated in allergic responses.read more
Citations
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Neutrophil elastase induces mucus cell metaplasia in mouse lung.
Judith A. Voynow,Bernard M. Fischer,David E. Malarkey,Lauranell H. Burch,Teresa Wong,Malinda Longphre,Samuel B. Ho,W. Michael Foster +7 more
TL;DR: These experiments suggest that NE proteolytic activity initiates an inflammatory process leading to goblet cell metaplasia.
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HIV-1 gp120 induces IL-4 and IL-13 release from human Fc epsilon RI+ cells through interaction with the VH3 region of IgE
TL;DR: Results indicate that gp120, which acts as a viral superantigen, interacts with the VH3 region of IgE to induce the release of IL-4 and IL-13 from human FcεRI+ cells.
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Methodology for the measurement of mucociliary function in the mouse by scintigraphy
TL;DR: Scintigraphy can discern particle deposition and clearance from the lower respiratory tract in the mouse, is noninvasive and reproducible, and includes the capability for restudy and lung lavage when time course or chronic treatments are being considered.
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Suppression of asthma-like responses in different mouse strains by oral tolerance.
Momtchilo Russo,Marie-Anne Nahori,Jean Lefort,Eliane Gomes,Alexandre C. Keller,Dunia Rodriguez,Orlando Garcia Ribeiro,Sahil Adriouch,Vallerie Gallois,Ana Maria Caetano Faria,B. Boris Vargaftig +10 more
TL;DR: Oral Ag administration was quite effective in suppressing the development of key features of asthma when initiated after primary immunization or after booster, but not when it increased allergic responses.
Journal ArticleDOI
Quantitative trait loci controlling allergen-induced airway hyperresponsiveness in inbred mice.
Susan Ewart,Douglas Kuperman,Eric E. Schadt,Clarke G. Tankersley,Andrew Grupe,Dennis M. Shubitowski,Gary Peltz,Marsha Wills-Karp +7 more
TL;DR: The strain distribution patterns for the asthma-related phenotypes airway hyperresponsiveness, lung eosinophils, and ovalbumin (OVA)-specific serum immunoglobulin (Ig) E induced by allergen exposure protocols are characterized and two distinct quantitative trait loci for susceptibility toallergen-induced AHR are identified.
References
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Jean Bousquet,Pascal Chanez,J.-Y. Lacoste,G. Barneon,N Ghavanian,I. Enander,Per Venge,Staffan Ahlstedt,J Simony-Lafontaine,P. Godard +9 more
TL;DR: Eosinophilic inflammation of the airways is correlated with the severity of asthma and these cells are likely to play a part in the epithelial damage seen in this disease.
Journal ArticleDOI
Requirement for IL-13 Independently of IL-4 in Experimental Asthma
Gabriele Grünig,Martha L. Warnock,Adil E. Wakil,Rajeev Venkayya,Frank Brombacher,Donna M. Rennick,Dean Sheppard,Markus Mohrs,Debra D. Donaldson,Richard M. Locksley,David B. Corry +10 more
TL;DR: This article showed that IL-4 receptor α chain-dependent pathway may underlie the genetic associations of asthma with both the human 5q31 locus and the IL4 receptor and showed that selective neutralization of IL-13, a cytokine related to interleukin-4 that also binds to the α chain of the IL 4 receptor, ameliorated asthma phenotype.
Journal ArticleDOI
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