Journal ArticleDOI
Irradiation in a flash: Unique sparing of memory in mice after whole brain irradiation with dose rates above 100 Gy/s
Pierre Montay-Gruel,Pierre Montay-Gruel,Kristoffer Petersson,Maud Jaccard,Gael Boivin,Jean-François Germond,Benoit Petit,Raphael Doenlen,Vincent Favaudon,François Bochud,Claude Bailat,Jean Bourhis,Marie-Catherine Vozenin +12 more
TLDR
This study shows for the first time that normal brain tissue toxicities after WBI can be reduced with increased dose rate.About:
This article is published in Radiotherapy and Oncology.The article was published on 2017-05-22. It has received 363 citations till now.read more
Citations
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Comparing fast imaging techniques for individual pulse imaging by Cherenkov in vivo from electron FLASH irradiation
Mahbubur Rahman,Muhammad Ramish Ashraf,Rongxiao Zhang,Xu Cao,David J. Gladstone,Lesley A. Jarvis,P. Jack Hoopes,Brian W. Pogue,Petr Bruza +8 more
TL;DR: This study investigates a fast-imaging technique of the first in vivo Cherenkov emission from an UHDR irradiator using an intensified CMOS camera and the effects of an intensifier (photocathode) on the image quality were considered concerning signal to noise ratio and spatial resolution.
Journal ArticleDOI
Fractionated FLASH radiation in xenografted lung tumors induced FLASH effect at a split dose of 2 Gy.
Yuling Dai,Runcheng Liang,Jianxin Wang,Jing Zhang,Dai-Lun Wu,Ri Zhao,Zhaoxing Liu,Faguo Chen +7 more
TL;DR: In this paper , the minimum split dose of FLASH radiotherapy (FLASH) was explored in the lungs of nude mice, and the effect of the FLASH effect on normal tissue sparing was evaluated.
Journal ArticleDOI
Comparable Long-Term Tumor Control for Hypofractionated FLASH Versus Conventional Radiation Therapy in an Immunocompetent Rat Glioma Model
Elise Konradsson,Emma Liljedahl,E.Mari Gustafsson,Gabriel Adrian,Sarah Beyer,S. E. Ilaahi,Kristoffer Petersson,Crister Ceberg,Henrietta Nittby Redebrandt +8 more
TL;DR: In this article , the authors evaluated tumor control and toxicity for hypofractionated FLASH-RT and conventional radiation therapy (CONV-RT) in an immunocompetent rat glioma model.
References
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Journal ArticleDOI
The novel object recognition memory: neurobiology, test procedure, and its modifications.
TL;DR: The neurobiology and methodological modifications of the test commonly used in behavioral pharmacology are reviewed to review the novel object recognition paradigms in animals, as a valuable measure of cognition.
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AAPM's TG-51 protocol for clinical reference dosimetry of high-energy photon and electron beams.
P. R. Almond,Peter J. Biggs,Bert M. Coursey,William F. Hanson,M. Saiful Huq,Ravinder Nath,David W. O. Rogers +6 more
TL;DR: This protocol represents a major simplification compared to the AAPM's TG-21 protocol in the sense that large tables of stopping-power ratios and mass-energy absorption coefficients are not needed and the user does not need to calculate any theoretical dosimetry factors.
Journal ArticleDOI
Neuroinflammation and M2 microglia: the good, the bad, and the inflamed.
TL;DR: The multiple possible activation states microglia can be polarized to are examined and particular attention is given to utilizing M2 microglial polarization as a potential therapeutic option in treating diseases.
Journal ArticleDOI
Ultrahigh dose-rate FLASH irradiation increases the differential response between normal and tumor tissue in mice
Vincent Favaudon,Vincent Favaudon,Laura Caplier,Virginie Monceau,Virginie Monceau,Frederic Pouzoulet,Frederic Pouzoulet,Mano Sayarath,Mano Sayarath,Charles Fouillade,Charles Fouillade,Marie-France Poupon,Marie-France Poupon,Isabel Brito,Isabel Brito,Philippe Hupé,Jean Bourhis,Jean Bourhis,Jean Bourhis,Janet Hall,Janet Hall,Jean-Jacques Fontaine,Marie-Catherine Vozenin +22 more
TL;DR: The results suggest that FLASH radiation may be a viable option for treating lung tumors and reduce the occurrence and severity of early and late complications affecting normal tissue.
Journal ArticleDOI
Radiation-induced impairment of hippocampal neurogenesis is associated with cognitive deficits in young mice
Radoslaw Rola,Jacob Raber,Angela Rizk,Shinji Otsuka,Scott R. VandenBerg,Duncan R. Morhardt,John R. Fike +6 more
TL;DR: Evidence is provided that irradiation of young animals induces a long-term impairment of dentate subgranular zone neurogenesis that is associated with hippocampal-dependent memory deficits.
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Long-term neurocognitive benefits of FLASH radiotherapy driven by reduced reactive oxygen species.
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