Journal ArticleDOI
Irradiation in a flash: Unique sparing of memory in mice after whole brain irradiation with dose rates above 100 Gy/s
Pierre Montay-Gruel,Pierre Montay-Gruel,Kristoffer Petersson,Maud Jaccard,Gael Boivin,Jean-François Germond,Benoit Petit,Raphael Doenlen,Vincent Favaudon,François Bochud,Claude Bailat,Jean Bourhis,Marie-Catherine Vozenin +12 more
TLDR
This study shows for the first time that normal brain tissue toxicities after WBI can be reduced with increased dose rate.About:
This article is published in Radiotherapy and Oncology.The article was published on 2017-05-22. It has received 363 citations till now.read more
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Abdominal FLASH irradiation reduces radiation-induced gastrointestinal toxicity for the treatment of ovarian cancer in mice.
Karen Levy,Suchitra Natarajan,Jinghui Wang,Stephanie Chow,Joshua T. Eggold,Phoebe Loo,Rakesh Manjappa,Stavros Melemenidis,Frederick M. Lartey,Emil Schüler,Lawrie Skinner,Marjan Rafat,Marjan Rafat,Ryan B. Ko,Anna Kim,Duaa H. Al-Rawi,Rie von Eyben,Oliver Dorigo,Kerriann M. Casey,Edward E. Graves,Karl Bush,Amy S. Yu,Albert C. Koong,P.G. Maxim,Billy W. Loo,Erinn B. Rankin +25 more
TL;DR: It is suggested that FLASH irradiation may be an effective strategy to enhance the therapeutic index of abdominal radiotherapy, with potential application to metastatic ovarian cancer.
Journal ArticleDOI
All the fun of the FAIR: fundamental physics at the facility for antiproton and ion research
Marco Durante,Paul Indelicato,Paul Indelicato,Björn Jonson,Björn Jonson,V. Koch,V. Koch,K. Langanke,Ulf-G. Meißner,E. Nappi,E. Nappi,Thomas Nilsson,Thomas Nilsson,Th. Stöhlker,Eberhard Widmann,Eberhard Widmann,Michael Wiescher,Michael Wiescher +17 more
TL;DR: The Facility for Antiproton and Ion Research (FAIR) as mentioned in this paper will be the accelerator-based flagship research facility in many basic sciences and their applications in Europe for the coming decades, which will open up unprecedented research opportunities in hadron and nuclear physics, in atomic physics and nuclear astrophysics as well as in applied sciences like materials research, plasma physics and radiation biophysics with applications towards novel medical treatments and space science.
Journal ArticleDOI
Comparative toxicity of synchrotron and conventional radiation therapy based on total and partial body irradiation in a murine model
Lloyd M. L. Smyth,Jacqueline F. Donoghue,Jacqueline F. Donoghue,Jessica Ventura,Jayde Livingstone,Tracy E. Bailey,Liam R. J. Day,Jeffrey C. Crosbie,Jeffrey C. Crosbie,Peter Rogers +9 more
TL;DR: This study provides the first in vivo dose-equivalence data between MRT, SBBR and CRT and presents systematic toxicity data for a range of organs that can be used as a reference point for future pre-clinical work.
Journal ArticleDOI
Dosimetric and preparation procedures for irradiating biological models with pulsed electron beam at ultra-high dose-rate.
Patrik Gonçalves Jorge,Maud Jaccard,Kristoffer Petersson,Maude Gondré,Maria Teresa Durán,Laurent Desorgher,Jean François Germond,Philippe Liger,Marie-Catherine Vozenin,Jean Bourhis,François Bochud,Raphaël Moeckli,Claude Bailat +12 more
TL;DR: The method is based on validated absolute dosimeters and extends their use to routine FLASH irradiations and developed the requirements needed for workflows of preclinical and clinical studies.
Journal ArticleDOI
Dosimetry for FLASH Radiotherapy: A Review of Tools and the Role of Radioluminescence and Cherenkov Emission
Muhammad Ramish Ashraf,Mahbubur Rahman,Rongxiao Zhang,Rongxiao Zhang,Benjamin B. Williams,Benjamin B. Williams,David J. Gladstone,David J. Gladstone,Brian W. Pogue,Brian W. Pogue,Petr Bruza +10 more
TL;DR: It is shown that luminescent detectors have a key role to play in the development of FLASH, as the field rapidly progresses toward clinical adaptation, and the unique ability of certain luminescence-based methods to provide tumor oxygenation maps in real-time with submillimeter resolution can elucidate the radiobiological mechanisms behind the FLASH effect.
References
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Journal ArticleDOI
The novel object recognition memory: neurobiology, test procedure, and its modifications.
TL;DR: The neurobiology and methodological modifications of the test commonly used in behavioral pharmacology are reviewed to review the novel object recognition paradigms in animals, as a valuable measure of cognition.
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AAPM's TG-51 protocol for clinical reference dosimetry of high-energy photon and electron beams.
P. R. Almond,Peter J. Biggs,Bert M. Coursey,William F. Hanson,M. Saiful Huq,Ravinder Nath,David W. O. Rogers +6 more
TL;DR: This protocol represents a major simplification compared to the AAPM's TG-21 protocol in the sense that large tables of stopping-power ratios and mass-energy absorption coefficients are not needed and the user does not need to calculate any theoretical dosimetry factors.
Journal ArticleDOI
Neuroinflammation and M2 microglia: the good, the bad, and the inflamed.
TL;DR: The multiple possible activation states microglia can be polarized to are examined and particular attention is given to utilizing M2 microglial polarization as a potential therapeutic option in treating diseases.
Journal ArticleDOI
Ultrahigh dose-rate FLASH irradiation increases the differential response between normal and tumor tissue in mice
Vincent Favaudon,Vincent Favaudon,Laura Caplier,Virginie Monceau,Virginie Monceau,Frederic Pouzoulet,Frederic Pouzoulet,Mano Sayarath,Mano Sayarath,Charles Fouillade,Charles Fouillade,Marie-France Poupon,Marie-France Poupon,Isabel Brito,Isabel Brito,Philippe Hupé,Jean Bourhis,Jean Bourhis,Jean Bourhis,Janet Hall,Janet Hall,Jean-Jacques Fontaine,Marie-Catherine Vozenin +22 more
TL;DR: The results suggest that FLASH radiation may be a viable option for treating lung tumors and reduce the occurrence and severity of early and late complications affecting normal tissue.
Journal ArticleDOI
Radiation-induced impairment of hippocampal neurogenesis is associated with cognitive deficits in young mice
Radoslaw Rola,Jacob Raber,Angela Rizk,Shinji Otsuka,Scott R. VandenBerg,Duncan R. Morhardt,John R. Fike +6 more
TL;DR: Evidence is provided that irradiation of young animals induces a long-term impairment of dentate subgranular zone neurogenesis that is associated with hippocampal-dependent memory deficits.
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