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Journal ArticleDOI

Irradiation in a flash: Unique sparing of memory in mice after whole brain irradiation with dose rates above 100 Gy/s

Pierre Montay-Gruel, +12 more
- 22 May 2017 - 
- Vol. 124, Iss: 3, pp 365-369
TLDR
This study shows for the first time that normal brain tissue toxicities after WBI can be reduced with increased dose rate.
About: 
This article is published in Radiotherapy and Oncology.The article was published on 2017-05-22. It has received 363 citations till now.

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Citations
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Journal ArticleDOI

FLASH Irradiation Results in Reduced Severe Skin Toxicity Compared to Conventional-Dose-Rate Irradiation

Luis A. Soto, +16 more
- 01 Dec 2020 - 
TL;DR: A shifting of the dose-response curve for radiation-induced skin ulceration to the right for FLASH, compared to CONV irradiation is suggested, suggesting the potential for an enhanced therapeutic index for radiation therapy of cancer.
Journal ArticleDOI

Radiotherapy Using High-Intensity Pulsed Radiation Beams (FLASH): A Radiation-Chemical Perspective.

Peter Wardman
- 20 May 2020 - 
TL;DR: Two scenarios are examined here that may provide a mechanistic basis for any differential response in normal tissues versus tumors in FLASH radiotherapy, and radical–radical reactions as a possible cause of effects occurring mainly with high-intensity pulsed radiation.
Journal ArticleDOI

Radiobiology of the FLASH effect.

Anna A. Friedl, +4 more
- 20 Sep 2021 - 
TL;DR: In this paper, the authors summarized the current evidence of the FLASH effect and reviewed FLASH-RT studies performed in preclinical models of normal tissue response, evaluating in vitro studies performed with normal and tumour cells.
Journal ArticleDOI

Ultra-high-dose-rate FLASH and Conventional-Dose-Rate Irradiation Differentially Affect Human Acute Lymphoblastic Leukemia and Normal Hematopoiesis

Sara Chabi, +11 more
- 01 Mar 2021 - 
TL;DR: The present findings are the first to show benefits of FLASH-TBI on human hematopoiesis and leukemia treatment and reduced functional damage to human blood stem cells and had a therapeutic effect on human T-ALL with a common genetic and genomic profile.
Journal ArticleDOI

May oxygen depletion explain the FLASH effect? A chemical track structure analysis.

Daria Boscolo, +4 more
- 29 Jun 2021 - 
TL;DR: In this article, a bottom-up approach starting from the chemical track evolution of 1-MeV electrons in oxygenated water simulated with the TRAX-CHEM Monte Carlo code was used to determine the oxygen consumption and radiolytic reactive oxygen species production following a short radiation pulse.
References
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Journal ArticleDOI

The novel object recognition memory: neurobiology, test procedure, and its modifications.

Marta Coelho Antunes, +2 more
- 01 May 2012 - 
TL;DR: The neurobiology and methodological modifications of the test commonly used in behavioral pharmacology are reviewed to review the novel object recognition paradigms in animals, as a valuable measure of cognition.
Journal ArticleDOI

AAPM's TG-51 protocol for clinical reference dosimetry of high-energy photon and electron beams.

P. R. Almond, +6 more
- 01 Sep 1999 - 
TL;DR: This protocol represents a major simplification compared to the AAPM's TG-21 protocol in the sense that large tables of stopping-power ratios and mass-energy absorption coefficients are not needed and the user does not need to calculate any theoretical dosimetry factors.
Journal ArticleDOI

Neuroinflammation and M2 microglia: the good, the bad, and the inflamed.

Jonathan D. Cherry, +2 more
- 03 Jun 2014 - 
TL;DR: The multiple possible activation states microglia can be polarized to are examined and particular attention is given to utilizing M2 microglial polarization as a potential therapeutic option in treating diseases.
Journal ArticleDOI

Ultrahigh dose-rate FLASH irradiation increases the differential response between normal and tumor tissue in mice

Vincent Favaudon, +22 more
- 16 Jul 2014 - 
TL;DR: The results suggest that FLASH radiation may be a viable option for treating lung tumors and reduce the occurrence and severity of early and late complications affecting normal tissue.
Journal ArticleDOI

Radiation-induced impairment of hippocampal neurogenesis is associated with cognitive deficits in young mice

Radoslaw Rola, +6 more
- 01 Aug 2004 - 
TL;DR: Evidence is provided that irradiation of young animals induces a long-term impairment of dentate subgranular zone neurogenesis that is associated with hippocampal-dependent memory deficits.
Related Papers (5)

Ultrahigh dose-rate FLASH irradiation increases the differential response between normal and tumor tissue in mice

Vincent Favaudon, +22 more
- 16 Jul 2014 - 

The Advantage of FLASH Radiotherapy Confirmed in Mini-pig and Cat-cancer Patients.

Marie-Catherine Vozenin, +15 more
- 01 Jan 2019 - 

Long-term neurocognitive benefits of FLASH radiotherapy driven by reduced reactive oxygen species.

Pierre Montay-Gruel, +21 more
- 28 May 2019 - 

Treatment of a first patient with FLASH-radiotherapy.

Jean Bourhis, +11 more
- 01 Oct 2019 - 

X-rays can trigger the FLASH effect: Ultra-high dose-rate synchrotron light source prevents normal brain injury after whole brain irradiation in mice.

Pierre Montay-Gruel, +11 more
- 31 Aug 2018 -