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Journal ArticleDOI

Irradiation in a flash: Unique sparing of memory in mice after whole brain irradiation with dose rates above 100 Gy/s

Pierre Montay-Gruel, +12 more
- 22 May 2017 - 
- Vol. 124, Iss: 3, pp 365-369
TLDR
This study shows for the first time that normal brain tissue toxicities after WBI can be reduced with increased dose rate.
About: 
This article is published in Radiotherapy and Oncology.The article was published on 2017-05-22. It has received 363 citations till now.

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Citations
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Journal ArticleDOI

Minimum dose rate estimation for pulsed FLASH radiotherapy: A dimensional analysis.

Sumin Zhou, +8 more
- 01 Jul 2020 - 
TL;DR: The Rmin introduced in this paper can be useful when designing a FLASH RT system and inversely proportional to the product of the square of the oxygen diffusion distance and the drop of intracellular [O2 ] per unit radiation dose.
Journal ArticleDOI

Radiobiology Experiments With Ultra-high Dose Rate Laser-Driven Protons: Methodology and State-of-the-Art

Pankaj Chaudhary, +6 more
- 08 Apr 2021 - 
TL;DR: The use of particle accelerators in radiotherapy has significantly changed the therapeutic outcomes for many types of solid tumours while carbon ions have been suggested to be particularly effective in the treatment of radio-resistant hypoxic tumours due to their higher Relative Biological Effectiveness (RBE) and Linear Energy Transfer (LET) values than protons as mentioned in this paper.
Journal ArticleDOI

First demonstration of the FLASH effect with ultrahigh dose rate high-energy X-rays

Feng Gao, +26 more
- 01 Jan 2022 - 
TL;DR: In this paper, the authors evaluated whether high-energy X-rays (HEXs) of the PARTER (platform for advanced radiotherapy research) platform built on CTFEL (Chengdu THz Free Electron Laser facility) can produce ultrahigh dose rate (FLASH) X-ray and trigger the FLASH effect.
Journal ArticleDOI

First demonstration of the FLASH effect with ultrahigh dose rate high-energy X-rays

- 01 Jan 2022 - 
TL;DR: In this paper , the authors evaluated whether high-energy X-rays (HEXs) of the PARTER (platform for advanced radiotherapy research) platform built on CTFEL (Chengdu THz Free Electron Laser facility) can produce ultrahigh dose rate (FLASH) X-ray and trigger the FLASH effect.
Journal ArticleDOI

Model studies of the role of oxygen in the FLASH effect

Vincent Favaudon, +2 more
- 18 Aug 2021 - 
TL;DR: In this paper, the effects of oxygen depletion on the radiation response of cell free, in vitro and in vivo model systems were investigated in FLASH radiotherapy (FLASH-RT), which relies on facilities capable of delivering ultrahigh dose rates in large doses in a single microsecond pulse, or in a few pulses given over a very short time sequence.
References
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Journal ArticleDOI

The novel object recognition memory: neurobiology, test procedure, and its modifications.

Marta Coelho Antunes, +2 more
- 01 May 2012 - 
TL;DR: The neurobiology and methodological modifications of the test commonly used in behavioral pharmacology are reviewed to review the novel object recognition paradigms in animals, as a valuable measure of cognition.
Journal ArticleDOI

AAPM's TG-51 protocol for clinical reference dosimetry of high-energy photon and electron beams.

P. R. Almond, +6 more
- 01 Sep 1999 - 
TL;DR: This protocol represents a major simplification compared to the AAPM's TG-21 protocol in the sense that large tables of stopping-power ratios and mass-energy absorption coefficients are not needed and the user does not need to calculate any theoretical dosimetry factors.
Journal ArticleDOI

Neuroinflammation and M2 microglia: the good, the bad, and the inflamed.

Jonathan D. Cherry, +2 more
- 03 Jun 2014 - 
TL;DR: The multiple possible activation states microglia can be polarized to are examined and particular attention is given to utilizing M2 microglial polarization as a potential therapeutic option in treating diseases.
Journal ArticleDOI

Ultrahigh dose-rate FLASH irradiation increases the differential response between normal and tumor tissue in mice

Vincent Favaudon, +22 more
- 16 Jul 2014 - 
TL;DR: The results suggest that FLASH radiation may be a viable option for treating lung tumors and reduce the occurrence and severity of early and late complications affecting normal tissue.
Journal ArticleDOI

Radiation-induced impairment of hippocampal neurogenesis is associated with cognitive deficits in young mice

Radoslaw Rola, +6 more
- 01 Aug 2004 - 
TL;DR: Evidence is provided that irradiation of young animals induces a long-term impairment of dentate subgranular zone neurogenesis that is associated with hippocampal-dependent memory deficits.
Related Papers (5)

Ultrahigh dose-rate FLASH irradiation increases the differential response between normal and tumor tissue in mice

Vincent Favaudon, +22 more
- 16 Jul 2014 - 

The Advantage of FLASH Radiotherapy Confirmed in Mini-pig and Cat-cancer Patients.

Marie-Catherine Vozenin, +15 more
- 01 Jan 2019 - 

Long-term neurocognitive benefits of FLASH radiotherapy driven by reduced reactive oxygen species.

Pierre Montay-Gruel, +21 more
- 28 May 2019 - 

Treatment of a first patient with FLASH-radiotherapy.

Jean Bourhis, +11 more
- 01 Oct 2019 - 

X-rays can trigger the FLASH effect: Ultra-high dose-rate synchrotron light source prevents normal brain injury after whole brain irradiation in mice.

Pierre Montay-Gruel, +11 more
- 31 Aug 2018 -