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Journal ArticleDOI

Irradiation in a flash: Unique sparing of memory in mice after whole brain irradiation with dose rates above 100 Gy/s

Pierre Montay-Gruel, +12 more
- 22 May 2017 - 
- Vol. 124, Iss: 3, pp 365-369
TLDR
This study shows for the first time that normal brain tissue toxicities after WBI can be reduced with increased dose rate.
About: 
This article is published in Radiotherapy and Oncology.The article was published on 2017-05-22. It has received 363 citations till now.

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Citations
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Journal ArticleDOI

FLASH Radiotherapy With Electrons: Issues Related to the Production, Monitoring, and Dosimetric Characterization of the Beam

Fabio Di Martino, +15 more
- 02 Nov 2020 - 
TL;DR: The problems and solutions concerning the realization of an electron accelerator dedicated to FLASH therapy and optimized for in vivo experiments are investigated and the saturation problems of the most common radiotherapy dosimeters when used in the very high dose-per-pulse FLASH conditions are discussed.
Journal ArticleDOI

Proton FLASH Radiotherapy for the Treatment of Symptomatic Bone Metastases: The FAST-01 Nonrandomized Trial.

A Mascia, +17 more
- 23 Oct 2022 - 
TL;DR: Clinical workflow metrics, treatment efficacy, and safety data demonstrated that ultra-high-dose-rate proton FLASH radiotherapy was clinically feasible and the treatment efficacy and the profile of adverse events were comparable with those of standard-of-care radiotherapy.
Journal ArticleDOI

Applied nuclear physics at the new high-energy particle accelerator facilities

Marco Durante, +4 more
- 10 Apr 2019 - 
TL;DR: In this paper, the authors summarize the current status of applied sciences at high-energy accelerators, describe the characteristics of some of the machines under construction (FAIR, NICA, RAON, ELI), and discuss the new opportunities offered by these facilities in applied sciences.
Journal ArticleDOI

FLASH Investigations Using Protons: Design of Delivery System, Preclinical Setup and Confirmation of FLASH Effect with Protons in Animal Systems

Qixian Zhang, +8 more
- 01 Dec 2020 - 
TL;DR: First results indicate a potential tissue-sparing effect of FLASH, and the development of a proton irradiation platform in a clinical proton facility and the dosimetry methods developed are reported.
Journal ArticleDOI

FLASH radiotherapy : ultra-high dose rates to spare healthy tissue

R.M. de Kruijff
- 01 Apr 2020 - 
TL;DR: An overview of the investigations into FLASH radiotherapy is presented, with promising results, supporting further clinical studies and the mechanisms underlying the biological effects remain to be elucidated.
References
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Journal ArticleDOI

The novel object recognition memory: neurobiology, test procedure, and its modifications.

Marta Coelho Antunes, +2 more
- 01 May 2012 - 
TL;DR: The neurobiology and methodological modifications of the test commonly used in behavioral pharmacology are reviewed to review the novel object recognition paradigms in animals, as a valuable measure of cognition.
Journal ArticleDOI

AAPM's TG-51 protocol for clinical reference dosimetry of high-energy photon and electron beams.

P. R. Almond, +6 more
- 01 Sep 1999 - 
TL;DR: This protocol represents a major simplification compared to the AAPM's TG-21 protocol in the sense that large tables of stopping-power ratios and mass-energy absorption coefficients are not needed and the user does not need to calculate any theoretical dosimetry factors.
Journal ArticleDOI

Neuroinflammation and M2 microglia: the good, the bad, and the inflamed.

Jonathan D. Cherry, +2 more
- 03 Jun 2014 - 
TL;DR: The multiple possible activation states microglia can be polarized to are examined and particular attention is given to utilizing M2 microglial polarization as a potential therapeutic option in treating diseases.
Journal ArticleDOI

Ultrahigh dose-rate FLASH irradiation increases the differential response between normal and tumor tissue in mice

Vincent Favaudon, +22 more
- 16 Jul 2014 - 
TL;DR: The results suggest that FLASH radiation may be a viable option for treating lung tumors and reduce the occurrence and severity of early and late complications affecting normal tissue.
Journal ArticleDOI

Radiation-induced impairment of hippocampal neurogenesis is associated with cognitive deficits in young mice

Radoslaw Rola, +6 more
- 01 Aug 2004 - 
TL;DR: Evidence is provided that irradiation of young animals induces a long-term impairment of dentate subgranular zone neurogenesis that is associated with hippocampal-dependent memory deficits.
Related Papers (5)

Ultrahigh dose-rate FLASH irradiation increases the differential response between normal and tumor tissue in mice

Vincent Favaudon, +22 more
- 16 Jul 2014 - 

The Advantage of FLASH Radiotherapy Confirmed in Mini-pig and Cat-cancer Patients.

Marie-Catherine Vozenin, +15 more
- 01 Jan 2019 - 

Long-term neurocognitive benefits of FLASH radiotherapy driven by reduced reactive oxygen species.

Pierre Montay-Gruel, +21 more
- 28 May 2019 - 

Treatment of a first patient with FLASH-radiotherapy.

Jean Bourhis, +11 more
- 01 Oct 2019 - 

X-rays can trigger the FLASH effect: Ultra-high dose-rate synchrotron light source prevents normal brain injury after whole brain irradiation in mice.

Pierre Montay-Gruel, +11 more
- 31 Aug 2018 -