Journal ArticleDOI
Irradiation in a flash: Unique sparing of memory in mice after whole brain irradiation with dose rates above 100 Gy/s
Pierre Montay-Gruel,Pierre Montay-Gruel,Kristoffer Petersson,Maud Jaccard,Gael Boivin,Jean-François Germond,Benoit Petit,Raphael Doenlen,Vincent Favaudon,François Bochud,Claude Bailat,Jean Bourhis,Marie-Catherine Vozenin +12 more
TLDR
This study shows for the first time that normal brain tissue toxicities after WBI can be reduced with increased dose rate.About:
This article is published in Radiotherapy and Oncology.The article was published on 2017-05-22. It has received 363 citations till now.read more
Citations
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Journal ArticleDOI
Shaping of a laser-accelerated proton beam for radiobiology applications via genetic algorithm.
TL;DR: In this article, the authors demonstrate the use of a GA to design an optimal non-flat scattering system to shape the beam and efficiently flatten the transversal dose distribution at the irradiated target.
Journal ArticleDOI
Proton FLASH effects on mouse skin at different oxygen tensions
Qixian Zhang,Leo E. Gerweck,E Cascio,Qingyuan Yang,Peigen Huang,Andrzej Niemierko,A. Bertolet,Konrad Pawel Nesteruk,Aimee L. McNamara,Jan Schuemann +9 more
TL;DR: In this article , double scattering proton system provided a 1.2 × 1.6 cm2 elliptical field at a dose rate of ∼130 Gy s−1, and the legs of the FVB/N mice were marked with two tattooed dots.
Journal ArticleDOI
A 60 MeV proton beam-line dedicated to research and development programs.
Petter Hofverberg,M. Antunes,Corsi Armando,J.-M. Bergerot,Emilie Bourrel,Joseph DiCarlo,G. Donadey,S. Dumas,D. Fayaud,Jean-Claude Grini,Arianna Giusto,Y. Payan,M. Rolion,C. Salicis,G. Angellier,J. Herault,Daniel Maneval,M. Vidal,P. Mandrillon,F. Bezerra,Jade Mekki,R. Trimaud +21 more
TL;DR: In this paper , a new proton beam-line dedicated to R&D programs has been developed at CentreAntoine Lacassagne (CAL), in Nice (France), in collaboration with the Centrenational d'études spatiales (CNES).
Journal ArticleDOI
Commissioning a 250 MeV research beamline for proton FLASH radiotherapy preclinical experiments.
Yunjie Yang,Minglei Kang,Chin Cheng Chen,Lei Hu,Francis Yu,Ping-Fang Tsai,Shenglan Huang,Jiayi Liu,Ryan S Turner,Brian Shen,Shaakir Hasan,Arpit M. Chhabra,J. Isabelle Choi,Brett Bell,Michael Pennock,Wolfgang A. Tomé,Chandan Guha,Charles B. Simone,Haibo Lin +18 more
TL;DR: In this paper , a 2D strip ionization chamber array (SICA) with high spatiotemporal resolution was used to measure spot dwell times under various beam currents and to quantify dose rates for various field sizes.
Journal ArticleDOI
3D printing for dosimetric optimization and quality assurance in small animal irradiations using megavoltage X-rays.
Nikolaos Koutsouvelis,Michel Rouzaud,A. Dubouloz,Philippe Nouet,Maud Jaccard,Valentina Garibotto,Benjamin B. Tournier,Thomas Zilli,Giovanna Dipasquale +8 more
TL;DR: The feasibility of modern megavoltage (MV) linear accelerator (LINAC)-based RT for small animals using easy-to-use consumer 3D printing technology for dosimetric optimization and quality assurance (QA) assessment is reported on.
References
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Journal ArticleDOI
The novel object recognition memory: neurobiology, test procedure, and its modifications.
TL;DR: The neurobiology and methodological modifications of the test commonly used in behavioral pharmacology are reviewed to review the novel object recognition paradigms in animals, as a valuable measure of cognition.
Journal ArticleDOI
AAPM's TG-51 protocol for clinical reference dosimetry of high-energy photon and electron beams.
P. R. Almond,Peter J. Biggs,Bert M. Coursey,William F. Hanson,M. Saiful Huq,Ravinder Nath,David W. O. Rogers +6 more
TL;DR: This protocol represents a major simplification compared to the AAPM's TG-21 protocol in the sense that large tables of stopping-power ratios and mass-energy absorption coefficients are not needed and the user does not need to calculate any theoretical dosimetry factors.
Journal ArticleDOI
Neuroinflammation and M2 microglia: the good, the bad, and the inflamed.
TL;DR: The multiple possible activation states microglia can be polarized to are examined and particular attention is given to utilizing M2 microglial polarization as a potential therapeutic option in treating diseases.
Journal ArticleDOI
Ultrahigh dose-rate FLASH irradiation increases the differential response between normal and tumor tissue in mice
Vincent Favaudon,Vincent Favaudon,Laura Caplier,Virginie Monceau,Virginie Monceau,Frederic Pouzoulet,Frederic Pouzoulet,Mano Sayarath,Mano Sayarath,Charles Fouillade,Charles Fouillade,Marie-France Poupon,Marie-France Poupon,Isabel Brito,Isabel Brito,Philippe Hupé,Jean Bourhis,Jean Bourhis,Jean Bourhis,Janet Hall,Janet Hall,Jean-Jacques Fontaine,Marie-Catherine Vozenin +22 more
TL;DR: The results suggest that FLASH radiation may be a viable option for treating lung tumors and reduce the occurrence and severity of early and late complications affecting normal tissue.
Journal ArticleDOI
Radiation-induced impairment of hippocampal neurogenesis is associated with cognitive deficits in young mice
Radoslaw Rola,Jacob Raber,Angela Rizk,Shinji Otsuka,Scott R. VandenBerg,Duncan R. Morhardt,John R. Fike +6 more
TL;DR: Evidence is provided that irradiation of young animals induces a long-term impairment of dentate subgranular zone neurogenesis that is associated with hippocampal-dependent memory deficits.
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Long-term neurocognitive benefits of FLASH radiotherapy driven by reduced reactive oxygen species.
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