Journal ArticleDOI
Irradiation in a flash: Unique sparing of memory in mice after whole brain irradiation with dose rates above 100 Gy/s
Pierre Montay-Gruel,Pierre Montay-Gruel,Kristoffer Petersson,Maud Jaccard,Gael Boivin,Jean-François Germond,Benoit Petit,Raphael Doenlen,Vincent Favaudon,François Bochud,Claude Bailat,Jean Bourhis,Marie-Catherine Vozenin +12 more
TLDR
This study shows for the first time that normal brain tissue toxicities after WBI can be reduced with increased dose rate.About:
This article is published in Radiotherapy and Oncology.The article was published on 2017-05-22. It has received 363 citations till now.read more
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Journal ArticleDOI
Characterization of the proton pulsed beam at CMAM
S. Viñals,D. Sánchez-Parcerisa,L. M. Fraile,Samuel España,G. García,M. García-Díaz,V. Sánchez-Tembleque,J. M. Udías +7 more
TL;DR: In this article, a pulsed beam has been characterized with an 8 MeV proton beam, using an existing equipment at CMAM: two pairs of electrostatic plates (RASTER) that deflect the beam, commonly used for homogeneous irradiation of large areas.
Journal ArticleDOI
A comprehensive analysis of the relationship between dose-rate and biological effects in pre-clinical and clinical studies, from brachytherapy to flattening filter-free radiation therapy and FLASH irradiation.
A. Beddok,Chloé Lahaye,Valentin Calugaru,Ludovic De Marzi,Charles Fouillade,S. Salvador,J.M. Fontbonne,Vincent Favaudon,Juliette Thariat +8 more
TL;DR: In this article , a critical review of preclinical and clinical studies to investigate the biological and clinical effects of dose rate variation in the range covering brachytherapy to flattening filter free EBRT and FLASH is presented.
Longitudinal Compression of Macro Relativistic Electron Beam
TL;DR: In this paper , a longitudinal bunch train compression method was proposed for manipulating relativistic electron beam in range of hundreds of meters, which has the potential to compress the electron beam generated by a conditional linear accelerator with a high ratio and raise its power to an high level comparable with large induction accelerators.
Journal ArticleDOI
Effects of Flash Radiotherapy on Blood Lymphocytes in Humans and Small Laboratory Animals
TL;DR: In this paper , a mathematical model which describes the level of surviving lymphocytes in the blood after ultra-high (FLASH) and lower dose rates of partial-body irradiation, is developed.
References
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Journal ArticleDOI
The novel object recognition memory: neurobiology, test procedure, and its modifications.
TL;DR: The neurobiology and methodological modifications of the test commonly used in behavioral pharmacology are reviewed to review the novel object recognition paradigms in animals, as a valuable measure of cognition.
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AAPM's TG-51 protocol for clinical reference dosimetry of high-energy photon and electron beams.
P. R. Almond,Peter J. Biggs,Bert M. Coursey,William F. Hanson,M. Saiful Huq,Ravinder Nath,David W. O. Rogers +6 more
TL;DR: This protocol represents a major simplification compared to the AAPM's TG-21 protocol in the sense that large tables of stopping-power ratios and mass-energy absorption coefficients are not needed and the user does not need to calculate any theoretical dosimetry factors.
Journal ArticleDOI
Neuroinflammation and M2 microglia: the good, the bad, and the inflamed.
TL;DR: The multiple possible activation states microglia can be polarized to are examined and particular attention is given to utilizing M2 microglial polarization as a potential therapeutic option in treating diseases.
Journal ArticleDOI
Ultrahigh dose-rate FLASH irradiation increases the differential response between normal and tumor tissue in mice
Vincent Favaudon,Vincent Favaudon,Laura Caplier,Virginie Monceau,Virginie Monceau,Frederic Pouzoulet,Frederic Pouzoulet,Mano Sayarath,Mano Sayarath,Charles Fouillade,Charles Fouillade,Marie-France Poupon,Marie-France Poupon,Isabel Brito,Isabel Brito,Philippe Hupé,Jean Bourhis,Jean Bourhis,Jean Bourhis,Janet Hall,Janet Hall,Jean-Jacques Fontaine,Marie-Catherine Vozenin +22 more
TL;DR: The results suggest that FLASH radiation may be a viable option for treating lung tumors and reduce the occurrence and severity of early and late complications affecting normal tissue.
Journal ArticleDOI
Radiation-induced impairment of hippocampal neurogenesis is associated with cognitive deficits in young mice
Radoslaw Rola,Jacob Raber,Angela Rizk,Shinji Otsuka,Scott R. VandenBerg,Duncan R. Morhardt,John R. Fike +6 more
TL;DR: Evidence is provided that irradiation of young animals induces a long-term impairment of dentate subgranular zone neurogenesis that is associated with hippocampal-dependent memory deficits.
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Ultrahigh dose-rate FLASH irradiation increases the differential response between normal and tumor tissue in mice
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Long-term neurocognitive benefits of FLASH radiotherapy driven by reduced reactive oxygen species.
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