Journal ArticleDOI
Irradiation in a flash: Unique sparing of memory in mice after whole brain irradiation with dose rates above 100 Gy/s
Pierre Montay-Gruel,Pierre Montay-Gruel,Kristoffer Petersson,Maud Jaccard,Gael Boivin,Jean-François Germond,Benoit Petit,Raphael Doenlen,Vincent Favaudon,François Bochud,Claude Bailat,Jean Bourhis,Marie-Catherine Vozenin +12 more
TLDR
This study shows for the first time that normal brain tissue toxicities after WBI can be reduced with increased dose rate.About:
This article is published in Radiotherapy and Oncology.The article was published on 2017-05-22. It has received 363 citations till now.read more
Citations
More filters
Journal ArticleDOI
The Advantage of FLASH Radiotherapy Confirmed in Mini-pig and Cat-cancer Patients.
Marie-Catherine Vozenin,Pauline de Fornel,Kristoffer Petersson,Vincent Favaudon,Maud Jaccard,Jean François Germond,Benoit Petit,Marco Burki,Gisele Ferrand,David Patin,Hanan Bouchaab,Mahmut Ozsahin,François Bochud,Claude Bailat,Patrick Devauchelle,Jean Bourhis +15 more
TL;DR: The results confirmed the potential advantage of FLASH-RT and provide a strong rationale for further evaluating FLash-RT in human patients.
Journal ArticleDOI
Treatment of a first patient with FLASH-radiotherapy.
Jean Bourhis,Wendy Jeanneret Sozzi,Patrik Gonçalves Jorge,Olivier Gaide,Claude Bailat,F. Duclos,David Patin,Mahmut Ozsahin,François Bochud,Jean-François Germond,Raphaël Moeckli,Marie-Catherine Vozenin +11 more
TL;DR: This first FLash-RT treatment was feasible and safe with a favorable outcome both on normal skin and the tumor, and prompt to further clinical evaluation of FLASH-RT.
Journal ArticleDOI
Biological Benefits of Ultra-high Dose Rate FLASH Radiotherapy: Sleeping Beauty Awoken.
TL;DR: The current knowledge about the FLASH effect is summarized and a synthesis of the observations that have been reported on various experimental animal models, various organs, and by various groups across 40 years of research are provided.
Journal ArticleDOI
Ultra-High Dose Rate (FLASH) Radiotherapy: Silver Bullet or Fool's Gold?
TL;DR: The tissue response to FLASH radiotherapy is examined, the evidence supporting hypotheses surrounding the biological basis of the FLASH effect is critically evaluated, and the potential for FLash radiotherapy to be translated into clinical contexts is considered.
Journal ArticleDOI
Long-term neurocognitive benefits of FLASH radiotherapy driven by reduced reactive oxygen species.
Pierre Montay-Gruel,Munjal M. Acharya,Kristoffer Petersson,Leila Alikhani,Chakradhar Yakkala,Barrett D. Allen,Jonathan Ollivier,Benoit Petit,Patrik Gonçalves Jorge,Amber R. Syage,Thuan Nguyen,Al Anoud D. Baddour,Celine Lu,Paramvir Singh,Raphaël Moeckli,François Bochud,Jean François Germond,Pascal Froidevaux,Claude Bailat,Jean Bourhis,Marie-Catherine Vozenin,Charles L. Limoli +21 more
TL;DR: The remarkable normal tissue sparing afforded by FLASH may someday provide heretofore unrealized opportunities for dose escalation to the tumor bed, capabilities that promise to hasten the translation of this groundbreaking irradiation modality into clinical practice.
References
More filters
Journal ArticleDOI
Effects of fractionated radiation on the brain vasculature in a murine model: blood-brain barrier permeability, astrocyte proliferation, and ultrastructural changes.
Hong Yuan,Hong Yuan,M. Waleed Gaber,Kelli L. Boyd,Christy M. Wilson,Mohammad F. Kiani,Thomas E. Merchant,Thomas E. Merchant +7 more
TL;DR: The cellular and microvasculature response of the brain to FRT is mediated through astrogliosis and ultrastructural changes, accompanied by an increase in BBB permeability.
Journal ArticleDOI
Radiation-induced astrocytic and microglial responses in mouse brain.
TL;DR: Levels of glial fibrillary acidic protein (GFAP), which is a marker for astrocytes, were measured by ELISA in irradiated brains taken at varying time points after irradiation and there was an increase in the number and the intensity of microglial cell staining for Mac I antigen.
Journal ArticleDOI
Vascular damage after fractionated whole-brain irradiation in rats.
TL;DR: It is suggested that the early (10-week) and persistent vascular damage that occurs after a prolonged whole-brain irradiation fractionation scheme may play an important role in the development of late delayed radiation-induced brain injury.
Journal ArticleDOI
Response of Postmitotic Neurons to X-Irradiation: Implications for the Role of DNA Damage in Neuronal Apoptosis
TL;DR: Data suggest that DNA damage may induce neuronal apoptosis, that the extent of damage may determine the degree of apoptosis induced, and that slow repair ofDamage may play a role in the susceptibility of neurons to apoptosis.
Journal ArticleDOI
High dose-per-pulse electron beam dosimetry - A model to correct for the ion recombination in the Advanced Markus ionization chamber.
Kristoffer Petersson,Maud Jaccard,Jean-François Germond,T. Buchillier,François Bochud,Jean Bourhis,Marie-Catherine Vozenin,Claude Bailat +7 more
TL;DR: The ion collection efficiency of the Advanced Markus ionization chamber decreases for measurements in electron beams with increasingly higher dose‐per‐pulse, but this chamber is still functional for dose measurements in beams with doses up toward and above 10 Gy, if the ion recombination is taken into account.
Related Papers (5)
Ultrahigh dose-rate FLASH irradiation increases the differential response between normal and tumor tissue in mice
Vincent Favaudon,Vincent Favaudon,Laura Caplier,Virginie Monceau,Virginie Monceau,Frederic Pouzoulet,Frederic Pouzoulet,Mano Sayarath,Mano Sayarath,Charles Fouillade,Charles Fouillade,Marie-France Poupon,Marie-France Poupon,Isabel Brito,Isabel Brito,Philippe Hupé,Jean Bourhis,Jean Bourhis,Jean Bourhis,Janet Hall,Janet Hall,Jean-Jacques Fontaine,Marie-Catherine Vozenin +22 more
The Advantage of FLASH Radiotherapy Confirmed in Mini-pig and Cat-cancer Patients.
Long-term neurocognitive benefits of FLASH radiotherapy driven by reduced reactive oxygen species.
Pierre Montay-Gruel,Munjal M. Acharya,Kristoffer Petersson,Leila Alikhani,Chakradhar Yakkala,Barrett D. Allen,Jonathan Ollivier,Benoit Petit,Patrik Gonçalves Jorge,Amber R. Syage,Thuan Nguyen,Al Anoud D. Baddour,Celine Lu,Paramvir Singh,Raphaël Moeckli,François Bochud,Jean François Germond,Pascal Froidevaux,Claude Bailat,Jean Bourhis,Marie-Catherine Vozenin,Charles L. Limoli +21 more