Journal ArticleDOI
Irradiation in a flash: Unique sparing of memory in mice after whole brain irradiation with dose rates above 100 Gy/s
Pierre Montay-Gruel,Pierre Montay-Gruel,Kristoffer Petersson,Maud Jaccard,Gael Boivin,Jean-François Germond,Benoit Petit,Raphael Doenlen,Vincent Favaudon,François Bochud,Claude Bailat,Jean Bourhis,Marie-Catherine Vozenin +12 more
TLDR
This study shows for the first time that normal brain tissue toxicities after WBI can be reduced with increased dose rate.About:
This article is published in Radiotherapy and Oncology.The article was published on 2017-05-22. It has received 363 citations till now.read more
Citations
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Journal ArticleDOI
A Quantitative Analysis of the Role of Oxygen Tension in FLASH Radiation Therapy
TL;DR: Oxygen depletion provides a credible quantitative model to understand the biological effects of FLASH radiotherapy and is compatible with a range of experimental observations ofFLASH sparing, highlighting the need for more detailed quantification of oxygen depletion under high dose rate radiation exposures in relevant systems.
Journal ArticleDOI
Bringing FLASH to the Clinic: Treatment Planning Considerations for Ultrahigh Dose-Rate Proton Beams.
Patricia van Marlen,Max Dahele,Michael Folkerts,Eric Abel,Berend J. Slotman,Wilko F.A.R. Verbakel +5 more
TL;DR: The methodology proposed in this proof-of-principle study provides a framework for evaluating the FLASH characteristics of scanning proton beam plans and can be adapted as FLASH-parameters are better defined.
Journal ArticleDOI
Understanding High-Dose, Ultra-High Dose Rate, and Spatially Fractionated Radiation Therapy.
Robert J. Griffin,Mansoor M. Ahmed,Beatriz E. Amendola,Oleg Belyakov,Søren M. Bentzen,Karl T. Butterworth,Sha Chang,C. Norman Coleman,Valentin Djonov,Sylvia C. Formenti,Eli Glatstein,Chandan Guha,Shalom Kalnicki,Quynh-Thu Le,Billy W. Loo,Anand Mahadevan,Mariangela Massaccesi,P.G. Maxim,Majid M. Mohiuddin,Mohammed Mohiuddin,N.A. Mayr,Ceferino Obcemea,Kristoffer Petersson,William F. Regine,Mack Roach,Pantaleo Romanelli,Charles B. Simone,James W. Snider,Douglas R. Spitz,Bhadrasain Vikram,Marie-Catherine Vozenin,May Abdel-Wahab,James S. Welsh,Xiaodong Wu,Charles L. Limoli +34 more
TL;DR: The National Cancer Institute's Radiation Research Program in collaboration with the Radiosurgery Society hosted a workshop on Understanding High-Dose, Ultra-High Dose rate and Spatially Fractionated Radiotherapy to understand the biological underpinning of these emerging techniques and the technical/physical parameters that must be further defined to drive clinical practice through innovative biologically-based clinical trials.
Journal ArticleDOI
Quantification of oxygen depletion during FLASH irradiation in vitro and in vivo.
Xu Cao,Rongxiao Zhang,Tatiana V. Esipova,Srinivasarao Allu,Ramish Ashraf,Mahbubur Rahman,Jason R. Gunn,Petr Bruza,David J. Gladstone,Benjamin B. Williams,Harold M. Swartz,P. Jack Hoopes,Sergei A. Vinogradov,Brian W. Pogue,Brian W. Pogue +14 more
TL;DR: In this article, the effects of radiation at ultra-high dose rates (UHDRs) on oxygen depletion in normal and tumor cells were measured in vitro and in vivo using a water-soluble molecular probe Oxyphor 2P.
Journal ArticleDOI
Ultra-high dose rate effect on circulating immune cells: A potential mechanism for FLASH effect?
J.Y. Jin,J.Y. Jin,Anxin Gu,Weili Wang,Nancy L. Oleinick,Mitchell Machtay,Feng-Ming Spring Kong +6 more
TL;DR: A strong sparing effect on circulating immune cells by FLASH-RT is calculated, which may contribute to the reported FLASH effects in animal studies.
References
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Journal ArticleDOI
The novel object recognition memory: neurobiology, test procedure, and its modifications.
TL;DR: The neurobiology and methodological modifications of the test commonly used in behavioral pharmacology are reviewed to review the novel object recognition paradigms in animals, as a valuable measure of cognition.
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AAPM's TG-51 protocol for clinical reference dosimetry of high-energy photon and electron beams.
P. R. Almond,Peter J. Biggs,Bert M. Coursey,William F. Hanson,M. Saiful Huq,Ravinder Nath,David W. O. Rogers +6 more
TL;DR: This protocol represents a major simplification compared to the AAPM's TG-21 protocol in the sense that large tables of stopping-power ratios and mass-energy absorption coefficients are not needed and the user does not need to calculate any theoretical dosimetry factors.
Journal ArticleDOI
Neuroinflammation and M2 microglia: the good, the bad, and the inflamed.
TL;DR: The multiple possible activation states microglia can be polarized to are examined and particular attention is given to utilizing M2 microglial polarization as a potential therapeutic option in treating diseases.
Journal ArticleDOI
Ultrahigh dose-rate FLASH irradiation increases the differential response between normal and tumor tissue in mice
Vincent Favaudon,Vincent Favaudon,Laura Caplier,Virginie Monceau,Virginie Monceau,Frederic Pouzoulet,Frederic Pouzoulet,Mano Sayarath,Mano Sayarath,Charles Fouillade,Charles Fouillade,Marie-France Poupon,Marie-France Poupon,Isabel Brito,Isabel Brito,Philippe Hupé,Jean Bourhis,Jean Bourhis,Jean Bourhis,Janet Hall,Janet Hall,Jean-Jacques Fontaine,Marie-Catherine Vozenin +22 more
TL;DR: The results suggest that FLASH radiation may be a viable option for treating lung tumors and reduce the occurrence and severity of early and late complications affecting normal tissue.
Journal ArticleDOI
Radiation-induced impairment of hippocampal neurogenesis is associated with cognitive deficits in young mice
Radoslaw Rola,Jacob Raber,Angela Rizk,Shinji Otsuka,Scott R. VandenBerg,Duncan R. Morhardt,John R. Fike +6 more
TL;DR: Evidence is provided that irradiation of young animals induces a long-term impairment of dentate subgranular zone neurogenesis that is associated with hippocampal-dependent memory deficits.
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Ultrahigh dose-rate FLASH irradiation increases the differential response between normal and tumor tissue in mice
Vincent Favaudon,Vincent Favaudon,Laura Caplier,Virginie Monceau,Virginie Monceau,Frederic Pouzoulet,Frederic Pouzoulet,Mano Sayarath,Mano Sayarath,Charles Fouillade,Charles Fouillade,Marie-France Poupon,Marie-France Poupon,Isabel Brito,Isabel Brito,Philippe Hupé,Jean Bourhis,Jean Bourhis,Jean Bourhis,Janet Hall,Janet Hall,Jean-Jacques Fontaine,Marie-Catherine Vozenin +22 more
The Advantage of FLASH Radiotherapy Confirmed in Mini-pig and Cat-cancer Patients.
Long-term neurocognitive benefits of FLASH radiotherapy driven by reduced reactive oxygen species.
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