Journal ArticleDOI
Irradiation in a flash: Unique sparing of memory in mice after whole brain irradiation with dose rates above 100 Gy/s
Pierre Montay-Gruel,Pierre Montay-Gruel,Kristoffer Petersson,Maud Jaccard,Gael Boivin,Jean-François Germond,Benoit Petit,Raphael Doenlen,Vincent Favaudon,François Bochud,Claude Bailat,Jean Bourhis,Marie-Catherine Vozenin +12 more
TLDR
This study shows for the first time that normal brain tissue toxicities after WBI can be reduced with increased dose rate.About:
This article is published in Radiotherapy and Oncology.The article was published on 2017-05-22. It has received 363 citations till now.read more
Citations
More filters
Journal ArticleDOI
A quantitative FLASH effectiveness model to reveal potentials and pitfalls of high dose rate proton therapy
Miriam Krieger,S. Van de Water,Michael Folkerts,Alejandro Mazal,S. Fabiano,Nicola Bizzocchi,Damien C. Weber,Sairos Safai,Antony J. Lomax +8 more
TL;DR: A phenomenological model provided a quantitative measure of the FLASH effect for various delivery and patient scenarios, supporting previous assumptions about potentially promising planning approaches for FLASH proton therapy.
Journal ArticleDOI
Normal tissue sparing by FLASH as a function of single fraction dose: A quantitative analysis.
T.T. Böhlen,Jean-François Germond,Jean Bourhis,Marie-Catherine Vozenin,Esat Mahmut Ozsahin,François Bochud,Claude Bailat,Raphaël Moeckli +7 more
TL;DR: In this article , the authors evaluated available experimental data on the magnitudes of normal tissue sparing provided by the FLASH effect as a function of dose, and followed a phenomenological data-driven approach for its parameterization.
Status of the CLEAR Electron Beam User Facility at CERN
Kyrre Sjobak,Erik Adli,Michele Bergamaschi,S. Burger,Roberto Corsini,Alessandro Curcio,S. Curt,Steffen Döbert,Wilfrid Farabolini,Davide Gamba,L. Garolfi,Antonio Gilardi,I. Gorgisyan,Eduardo Granados,Helene Guerin,Robert Kieffer,M. Krupa,Thibaut Lefèvre,C. A. Lindstrøm,Alexey Lyapin,Stefano Mazzoni,Gerard McMonagle,Johannes Nadenau,H. Panuganti,Sam Pitman,Vivien Rude,Anders Schlogelhofer,Piotr Skowroński,Manfred Wendt,Anna Zemanek +29 more
TL;DR: The CERN Linear Electron Accelerator for Research (CLEAR) has now finished its second year of operation, providing a testbed for new accelerator technologies and a versatile radiation source.
Journal ArticleDOI
Development of an ultra‐thin parallel plate ionization chamber for dosimetry in FLASH radiotherapy
Faustino Gómez,D.M. González-Castaño,Nicolás Gómez Fernández,Juan Pardo-Montero,A. Schüller,Alessia Gasparini,Verdi Vanreusel,Dirk Verellen,G. Felici,Rafael Kranzer,J. Paz-Martín +10 more
TL;DR: The results show that ultra-thin parallel plate ionization chambers are suitable for measurement in ultra-high dose rate electron beams and demonstrate the ability to extend the dose rate operating range of ionization chamber to ultra- high dose per pulse range by reducing the spacing between electrodes.
Journal ArticleDOI
Ultra-high dose rate transmission beam proton therapy for conventionally fractionated head and neck cancer: Treatment planning and dose rate distributions
Patricia van Marlen,Max Dahele,Michael Folkerts,Eric Abel,Ben J. Slotman,Wilko F.A.R. Verbakel +5 more
TL;DR: In this paper, plan quality for conventionally-fractionated head-and-neck cancer treatment using spot-scanning proton TBs, intensity-modulated PT (IMPT) and photon volumetric modulated arc therapy (VMAT), delivering 70/54.25 Gy in 35 fractions to boost/elective volumes, were compared.
References
More filters
Journal ArticleDOI
The novel object recognition memory: neurobiology, test procedure, and its modifications.
TL;DR: The neurobiology and methodological modifications of the test commonly used in behavioral pharmacology are reviewed to review the novel object recognition paradigms in animals, as a valuable measure of cognition.
Journal ArticleDOI
AAPM's TG-51 protocol for clinical reference dosimetry of high-energy photon and electron beams.
P. R. Almond,Peter J. Biggs,Bert M. Coursey,William F. Hanson,M. Saiful Huq,Ravinder Nath,David W. O. Rogers +6 more
TL;DR: This protocol represents a major simplification compared to the AAPM's TG-21 protocol in the sense that large tables of stopping-power ratios and mass-energy absorption coefficients are not needed and the user does not need to calculate any theoretical dosimetry factors.
Journal ArticleDOI
Neuroinflammation and M2 microglia: the good, the bad, and the inflamed.
TL;DR: The multiple possible activation states microglia can be polarized to are examined and particular attention is given to utilizing M2 microglial polarization as a potential therapeutic option in treating diseases.
Journal ArticleDOI
Ultrahigh dose-rate FLASH irradiation increases the differential response between normal and tumor tissue in mice
Vincent Favaudon,Vincent Favaudon,Laura Caplier,Virginie Monceau,Virginie Monceau,Frederic Pouzoulet,Frederic Pouzoulet,Mano Sayarath,Mano Sayarath,Charles Fouillade,Charles Fouillade,Marie-France Poupon,Marie-France Poupon,Isabel Brito,Isabel Brito,Philippe Hupé,Jean Bourhis,Jean Bourhis,Jean Bourhis,Janet Hall,Janet Hall,Jean-Jacques Fontaine,Marie-Catherine Vozenin +22 more
TL;DR: The results suggest that FLASH radiation may be a viable option for treating lung tumors and reduce the occurrence and severity of early and late complications affecting normal tissue.
Journal ArticleDOI
Radiation-induced impairment of hippocampal neurogenesis is associated with cognitive deficits in young mice
Radoslaw Rola,Jacob Raber,Angela Rizk,Shinji Otsuka,Scott R. VandenBerg,Duncan R. Morhardt,John R. Fike +6 more
TL;DR: Evidence is provided that irradiation of young animals induces a long-term impairment of dentate subgranular zone neurogenesis that is associated with hippocampal-dependent memory deficits.
Related Papers (5)
Ultrahigh dose-rate FLASH irradiation increases the differential response between normal and tumor tissue in mice
Vincent Favaudon,Vincent Favaudon,Laura Caplier,Virginie Monceau,Virginie Monceau,Frederic Pouzoulet,Frederic Pouzoulet,Mano Sayarath,Mano Sayarath,Charles Fouillade,Charles Fouillade,Marie-France Poupon,Marie-France Poupon,Isabel Brito,Isabel Brito,Philippe Hupé,Jean Bourhis,Jean Bourhis,Jean Bourhis,Janet Hall,Janet Hall,Jean-Jacques Fontaine,Marie-Catherine Vozenin +22 more
The Advantage of FLASH Radiotherapy Confirmed in Mini-pig and Cat-cancer Patients.
Long-term neurocognitive benefits of FLASH radiotherapy driven by reduced reactive oxygen species.
Pierre Montay-Gruel,Munjal M. Acharya,Kristoffer Petersson,Leila Alikhani,Chakradhar Yakkala,Barrett D. Allen,Jonathan Ollivier,Benoit Petit,Patrik Gonçalves Jorge,Amber R. Syage,Thuan Nguyen,Al Anoud D. Baddour,Celine Lu,Paramvir Singh,Raphaël Moeckli,François Bochud,Jean François Germond,Pascal Froidevaux,Claude Bailat,Jean Bourhis,Marie-Catherine Vozenin,Charles L. Limoli +21 more