Journal ArticleDOI
Irradiation in a flash: Unique sparing of memory in mice after whole brain irradiation with dose rates above 100 Gy/s
Pierre Montay-Gruel,Pierre Montay-Gruel,Kristoffer Petersson,Maud Jaccard,Gael Boivin,Jean-François Germond,Benoit Petit,Raphael Doenlen,Vincent Favaudon,François Bochud,Claude Bailat,Jean Bourhis,Marie-Catherine Vozenin +12 more
TLDR
This study shows for the first time that normal brain tissue toxicities after WBI can be reduced with increased dose rate.About:
This article is published in Radiotherapy and Oncology.The article was published on 2017-05-22. It has received 363 citations till now.read more
Citations
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Organoids as Complex In Vitro Models for Studying Radiation-Induced Cell Recruitment
TL;DR: Recent advances in mammary organoid technology are evaluated, the advantages of using organoids to study radiation response are considered, and future directions for the applications of this technique are discussed.
Journal ArticleDOI
Dosimetric characterisation and application to radiation biology of a kHz laser-driven electron beam
M. Cavallone,M. Cavallone,Lucas Rovige,Julius Huijts,Emilie Bayart,Rachel Delorme,Aline Vernier,Patrik Gonçalves Jorge,Raphaël Moeckli,Eric Deutsch,Jérôme Faure,Alessandro Flacco +11 more
TL;DR: In this paper, the authors presented the dosimetric characterisation of a kHz, low energy laser-driven electron source and preliminary results on in-vitro irradiation of cancer cells.
Journal ArticleDOI
Stereotactic radiotherapy for early stage non-small cell lung cancer: current standards and ongoing research
TL;DR: International guidelines and the current standard of care, ongoing clinical challenges and future directions from the clinical and technical point of view are discussed.
Journal ArticleDOI
FLASH radiotherapy treatment planning and models for electron beams.
Mahbubur Rahman,Antonio Trigilio,Gaia Franciosini,Raphaël Moeckli,Rongxiao Zhang,Till Tobias Böhlen +5 more
TL;DR: In this paper , the authors present a review of the TPS developments in high-energy electron (HEE) and very high energy electron (VHEE, 50-250 MeV) beam models, characteristics, and future FLASH applications.
Journal ArticleDOI
Advanced pencil beam scanning Bragg peak FLASH-RT delivery technique can enhance lung cancer planning treatment outcomes compared to conventional multiple-energy proton PBS techniques.
TL;DR: In this article , a single-energy PBS Bragg peak FLASH treatment plans were optimized based on a novel tracking technique to enable Bragg peaks to stop at the distal edge of the target.
References
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The novel object recognition memory: neurobiology, test procedure, and its modifications.
TL;DR: The neurobiology and methodological modifications of the test commonly used in behavioral pharmacology are reviewed to review the novel object recognition paradigms in animals, as a valuable measure of cognition.
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AAPM's TG-51 protocol for clinical reference dosimetry of high-energy photon and electron beams.
P. R. Almond,Peter J. Biggs,Bert M. Coursey,William F. Hanson,M. Saiful Huq,Ravinder Nath,David W. O. Rogers +6 more
TL;DR: This protocol represents a major simplification compared to the AAPM's TG-21 protocol in the sense that large tables of stopping-power ratios and mass-energy absorption coefficients are not needed and the user does not need to calculate any theoretical dosimetry factors.
Journal ArticleDOI
Neuroinflammation and M2 microglia: the good, the bad, and the inflamed.
TL;DR: The multiple possible activation states microglia can be polarized to are examined and particular attention is given to utilizing M2 microglial polarization as a potential therapeutic option in treating diseases.
Journal ArticleDOI
Ultrahigh dose-rate FLASH irradiation increases the differential response between normal and tumor tissue in mice
Vincent Favaudon,Vincent Favaudon,Laura Caplier,Virginie Monceau,Virginie Monceau,Frederic Pouzoulet,Frederic Pouzoulet,Mano Sayarath,Mano Sayarath,Charles Fouillade,Charles Fouillade,Marie-France Poupon,Marie-France Poupon,Isabel Brito,Isabel Brito,Philippe Hupé,Jean Bourhis,Jean Bourhis,Jean Bourhis,Janet Hall,Janet Hall,Jean-Jacques Fontaine,Marie-Catherine Vozenin +22 more
TL;DR: The results suggest that FLASH radiation may be a viable option for treating lung tumors and reduce the occurrence and severity of early and late complications affecting normal tissue.
Journal ArticleDOI
Radiation-induced impairment of hippocampal neurogenesis is associated with cognitive deficits in young mice
Radoslaw Rola,Jacob Raber,Angela Rizk,Shinji Otsuka,Scott R. VandenBerg,Duncan R. Morhardt,John R. Fike +6 more
TL;DR: Evidence is provided that irradiation of young animals induces a long-term impairment of dentate subgranular zone neurogenesis that is associated with hippocampal-dependent memory deficits.
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