Journal ArticleDOI
Irradiation in a flash: Unique sparing of memory in mice after whole brain irradiation with dose rates above 100 Gy/s
Pierre Montay-Gruel,Pierre Montay-Gruel,Kristoffer Petersson,Maud Jaccard,Gael Boivin,Jean-François Germond,Benoit Petit,Raphael Doenlen,Vincent Favaudon,François Bochud,Claude Bailat,Jean Bourhis,Marie-Catherine Vozenin +12 more
TLDR
This study shows for the first time that normal brain tissue toxicities after WBI can be reduced with increased dose rate.About:
This article is published in Radiotherapy and Oncology.The article was published on 2017-05-22. It has received 363 citations till now.read more
Citations
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Journal ArticleDOI
Optimization of FLASH proton beams using a track‐repeating algorithm
Qianxia Wang,M. Munier +1 more
TL;DR: In this paper , a set of automatic FLASH proton beam optimization algorithms were developed and tested using two proton energies (87.0 MeV and 159.5 MeV) in a variety of beam line arrangements.
Journal ArticleDOI
Point scintillator dosimetry in ultra-high dose rate electron "FLASH" radiation therapy: A first characterization.
Verdi Vanreusel,Alessia Gasparini,F. Galante,Giulia Mariani,M. Pacitti,Madalina Cociorb,Andrea Giammanco,Brigitte Reniers,Nathalie Reulens,Tunde Blessed Shonde,Hugo Vallet,Dirk Vandenbroucke,Marc Peeters,Paul Leblans,B Ma,G. Felici,Dirk Verellen,L. de Freitas Nascimento +17 more
TL;DR: In this paper , a characterization of 6 real-time point scintillating dosimeters with 5 phosphors (Al2O3:C,Mg, Y2O-3:Eu, Al2O 3:C; Al 2O 3 :C; (C38H34P2)MnBr4 and (C 38H34p2)mnCl4) was performed in an UHDR pulsed electron beam.
Journal ArticleDOI
Impact of respiratory motion on proton pencil beam scanning FLASH radiotherapy: an in silico and phantom measurement study
Yunjie Yang,Minglei Kang,Shenglan Huang,Chin Cheng Chen,Ping-Fang Tsai,Lei Hu,Francis Yu,Carla Hajj,J. Isabelle Choi,Wolfgang A. Tomé,Charles B. Simone,Haibo Lin +11 more
TL;DR: In this paper , the effects of respiratory motion on the delivered dose in the context of proton pencil beam scanning (PBS) transmission FLASH radiotherapy (FLASH-RT) by simulation and phantom measurements were investigated.
Journal ArticleDOI
Technical Note: FLASH radiotherapy monitor chamber signal conditioning
Michael Snyder,Michael Snyder,Jessica Vadas,John Musselwhite,Robert Halford,George S. Wilson,George S. Wilson,Craig W. Stevens,Craig W. Stevens,Di Yan,Di Yan +10 more
TL;DR: Preliminary results indicate that current-generation monitor chambers could potentially govern FLASH radiotherapy, but overall beam and monitor chamber stability issues may necessitate machine modifications to achieve desired dosimetric accuracy.
Posted ContentDOI
FLASH and Conventional Radiation Induce Differential Immune Responses in Diffuse Intrinsic Pontine Glioma, Highlighting Potential for Combination Immunotherapy
Oscar A. Padilla,H. Minns,Hong Jian Wei,Andrea Marcela Webster-Carrion,Masih Tazhibi,N. McQuillan,Xu Zhang,Rebecca C. Yeh,Zhiguo Zhang,Tom K. Hei,Luca,Szalontay,Jovana Pavisic,Guy Garty,James Garvin,Peter Canoll,I. Coirç Claire,Vilas Menon,Marta Olah,Raul Rabadan,Cheng-Chia Wu,Robyn D. Gartrell +21 more
TL;DR: In this article , the effect of FLASH on the DIPG tumor immune micro-environment (TIME) has not yet been explored, however, the authors perform single-cell RNA sequencing on immune cells isolated from an orthotopic syngeneic murine model of DIPGs following the use of Flashing (90Gy/sec) or conventional (2Gy/min) dose-rate RT (CONV-RT).
References
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Journal ArticleDOI
The novel object recognition memory: neurobiology, test procedure, and its modifications.
TL;DR: The neurobiology and methodological modifications of the test commonly used in behavioral pharmacology are reviewed to review the novel object recognition paradigms in animals, as a valuable measure of cognition.
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AAPM's TG-51 protocol for clinical reference dosimetry of high-energy photon and electron beams.
P. R. Almond,Peter J. Biggs,Bert M. Coursey,William F. Hanson,M. Saiful Huq,Ravinder Nath,David W. O. Rogers +6 more
TL;DR: This protocol represents a major simplification compared to the AAPM's TG-21 protocol in the sense that large tables of stopping-power ratios and mass-energy absorption coefficients are not needed and the user does not need to calculate any theoretical dosimetry factors.
Journal ArticleDOI
Neuroinflammation and M2 microglia: the good, the bad, and the inflamed.
TL;DR: The multiple possible activation states microglia can be polarized to are examined and particular attention is given to utilizing M2 microglial polarization as a potential therapeutic option in treating diseases.
Journal ArticleDOI
Ultrahigh dose-rate FLASH irradiation increases the differential response between normal and tumor tissue in mice
Vincent Favaudon,Vincent Favaudon,Laura Caplier,Virginie Monceau,Virginie Monceau,Frederic Pouzoulet,Frederic Pouzoulet,Mano Sayarath,Mano Sayarath,Charles Fouillade,Charles Fouillade,Marie-France Poupon,Marie-France Poupon,Isabel Brito,Isabel Brito,Philippe Hupé,Jean Bourhis,Jean Bourhis,Jean Bourhis,Janet Hall,Janet Hall,Jean-Jacques Fontaine,Marie-Catherine Vozenin +22 more
TL;DR: The results suggest that FLASH radiation may be a viable option for treating lung tumors and reduce the occurrence and severity of early and late complications affecting normal tissue.
Journal ArticleDOI
Radiation-induced impairment of hippocampal neurogenesis is associated with cognitive deficits in young mice
Radoslaw Rola,Jacob Raber,Angela Rizk,Shinji Otsuka,Scott R. VandenBerg,Duncan R. Morhardt,John R. Fike +6 more
TL;DR: Evidence is provided that irradiation of young animals induces a long-term impairment of dentate subgranular zone neurogenesis that is associated with hippocampal-dependent memory deficits.
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Ultrahigh dose-rate FLASH irradiation increases the differential response between normal and tumor tissue in mice
Vincent Favaudon,Vincent Favaudon,Laura Caplier,Virginie Monceau,Virginie Monceau,Frederic Pouzoulet,Frederic Pouzoulet,Mano Sayarath,Mano Sayarath,Charles Fouillade,Charles Fouillade,Marie-France Poupon,Marie-France Poupon,Isabel Brito,Isabel Brito,Philippe Hupé,Jean Bourhis,Jean Bourhis,Jean Bourhis,Janet Hall,Janet Hall,Jean-Jacques Fontaine,Marie-Catherine Vozenin +22 more
The Advantage of FLASH Radiotherapy Confirmed in Mini-pig and Cat-cancer Patients.
Long-term neurocognitive benefits of FLASH radiotherapy driven by reduced reactive oxygen species.
Pierre Montay-Gruel,Munjal M. Acharya,Kristoffer Petersson,Leila Alikhani,Chakradhar Yakkala,Barrett D. Allen,Jonathan Ollivier,Benoit Petit,Patrik Gonçalves Jorge,Amber R. Syage,Thuan Nguyen,Al Anoud D. Baddour,Celine Lu,Paramvir Singh,Raphaël Moeckli,François Bochud,Jean François Germond,Pascal Froidevaux,Claude Bailat,Jean Bourhis,Marie-Catherine Vozenin,Charles L. Limoli +21 more