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Journal ArticleDOI

Irradiation in a flash: Unique sparing of memory in mice after whole brain irradiation with dose rates above 100 Gy/s

Pierre Montay-Gruel, +12 more
- 22 May 2017 - 
- Vol. 124, Iss: 3, pp 365-369
TLDR
This study shows for the first time that normal brain tissue toxicities after WBI can be reduced with increased dose rate.
About: 
This article is published in Radiotherapy and Oncology.The article was published on 2017-05-22. It has received 363 citations till now.

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Citations
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Journal ArticleDOI

Biological and Mechanical Synergies to Deal With Proton Therapy Pitfalls: Minibeams, FLASH, Arcs, and Gantryless Rooms.

Alejandro Mazal, +25 more
- 21 Jan 2021 - 
TL;DR: In this article, a review of beam management in time and modulation in space for proton therapy is presented, together with rotational techniques optimized in partial arcs and gantryless delivery systems.
Journal ArticleDOI

FLASH irradiation induces lower levels of DNA damage ex vivo, an effect modulated by oxygen tension, dose, and dose rate.

C. Cooper, +3 more
- 16 Feb 2022 - 
TL;DR: This paper is first to directly show that FLASH-induced DNA damage is modulated by oxygen tension, total dose and dose rate, with FLASH inducing significantly lower levels of DNA damage for doses ≥20 Gy and dose rates ≥30 Gy/s.
Journal ArticleDOI

Cured in a FLASH: Reducing Normal Tissue Toxicities Using Ultra-High-Dose Rates.

Hania A. Al-Hallaq, +3 more
- 01 Jun 2019 - 
Journal ArticleDOI

A Novel Proton Pencil Beam Scanning FLASH RT Delivery Method Enables Optimal OAR Sparing and Ultra-High Dose Rate Delivery: A Comprehensive Dosimetry Study for Lung Tumors.

Shouyi Wei, +4 more
- 18 Nov 2021 - 
TL;DR: In this paper, the authors compared single energy Bragg peak proton beam plans with transmission beam plans in lung tumors and evaluated the effect of beam angular optimization on the beam angles.
Journal ArticleDOI

Compact S -band linear accelerator system for ultrafast, ultrahigh dose-rate radiotherapy

Luigi Faillace, +15 more
- 17 May 2021 - 
TL;DR: The first dedicated compact $S$-band linear accelerator for FLASH radiotherapy is developed, optimized for a nominal energy of 7 MeV and a pulsed electron beam current of 100 mA and above, mounted on a remote-controlled system for preclinical research studies in the FLASH regime.
References
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Journal ArticleDOI

The novel object recognition memory: neurobiology, test procedure, and its modifications.

Marta Coelho Antunes, +2 more
- 01 May 2012 - 
TL;DR: The neurobiology and methodological modifications of the test commonly used in behavioral pharmacology are reviewed to review the novel object recognition paradigms in animals, as a valuable measure of cognition.
Journal ArticleDOI

AAPM's TG-51 protocol for clinical reference dosimetry of high-energy photon and electron beams.

P. R. Almond, +6 more
- 01 Sep 1999 - 
TL;DR: This protocol represents a major simplification compared to the AAPM's TG-21 protocol in the sense that large tables of stopping-power ratios and mass-energy absorption coefficients are not needed and the user does not need to calculate any theoretical dosimetry factors.
Journal ArticleDOI

Neuroinflammation and M2 microglia: the good, the bad, and the inflamed.

Jonathan D. Cherry, +2 more
- 03 Jun 2014 - 
TL;DR: The multiple possible activation states microglia can be polarized to are examined and particular attention is given to utilizing M2 microglial polarization as a potential therapeutic option in treating diseases.
Journal ArticleDOI

Ultrahigh dose-rate FLASH irradiation increases the differential response between normal and tumor tissue in mice

Vincent Favaudon, +22 more
- 16 Jul 2014 - 
TL;DR: The results suggest that FLASH radiation may be a viable option for treating lung tumors and reduce the occurrence and severity of early and late complications affecting normal tissue.
Journal ArticleDOI

Radiation-induced impairment of hippocampal neurogenesis is associated with cognitive deficits in young mice

Radoslaw Rola, +6 more
- 01 Aug 2004 - 
TL;DR: Evidence is provided that irradiation of young animals induces a long-term impairment of dentate subgranular zone neurogenesis that is associated with hippocampal-dependent memory deficits.
Related Papers (5)

Ultrahigh dose-rate FLASH irradiation increases the differential response between normal and tumor tissue in mice

Vincent Favaudon, +22 more
- 16 Jul 2014 - 

The Advantage of FLASH Radiotherapy Confirmed in Mini-pig and Cat-cancer Patients.

Marie-Catherine Vozenin, +15 more
- 01 Jan 2019 - 

Long-term neurocognitive benefits of FLASH radiotherapy driven by reduced reactive oxygen species.

Pierre Montay-Gruel, +21 more
- 28 May 2019 - 

Treatment of a first patient with FLASH-radiotherapy.

Jean Bourhis, +11 more
- 01 Oct 2019 - 

X-rays can trigger the FLASH effect: Ultra-high dose-rate synchrotron light source prevents normal brain injury after whole brain irradiation in mice.

Pierre Montay-Gruel, +11 more
- 31 Aug 2018 -