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Journal ArticleDOI

Irradiation in a flash: Unique sparing of memory in mice after whole brain irradiation with dose rates above 100 Gy/s

Pierre Montay-Gruel, +12 more
- 22 May 2017 - 
- Vol. 124, Iss: 3, pp 365-369
TLDR
This study shows for the first time that normal brain tissue toxicities after WBI can be reduced with increased dose rate.
About: 
This article is published in Radiotherapy and Oncology.The article was published on 2017-05-22. It has received 363 citations till now.

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Citations
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Journal ArticleDOI

Nanoparticle radio-enhancement: principles, progress and application to cancer treatment

Zdenka Kuncic, +1 more
- 09 Jan 2018 - 
TL;DR: The purpose of this Topical Review is to consolidate findings from the different studies and summarise progress to date, as well as to identify strategies that offer promising opportunities for clinical translation.
Journal ArticleDOI

Faster and safer? FLASH ultra-high dose rate in radiotherapy.

Marco Durante, +2 more
- 15 Dec 2017 - 
TL;DR: The Franco-Swiss team of Institute Curie and Centre Hospitalier Universitaire Vaudois demonstrate a remarkable sparing of normal tissue after irradiation at ultra- high dose rate, suggesting that ultra-high dose rate can substantially enhance the therapeutic window in radiotherapy.
Journal ArticleDOI

Reduced cognitive deficits after FLASH irradiation of whole mouse brain are associated with less hippocampal dendritic spine loss and neuroinflammation.

Danielle A. Simmons, +18 more
- 01 Oct 2019 - 
TL;DR: In this article, the impact of ultra-rapid FLASH mouse whole brain irradiation on hippocampal dendritic spines and neuroinflammation was evaluated with a custom configured clinical linac.
Journal ArticleDOI

High dose-per-pulse electron beam dosimetry: Commissioning of the Oriatron eRT6 prototype linear accelerator for preclinical use.

Maud Jaccard, +8 more
- 01 Feb 2018 - 
TL;DR: The beam monitoring system was able to measure in a reproducible way the total charge of electrons that exit the machine, as long as the electron pulse amplitude remains above a given threshold, which is suitable mainly for small animal irradiation.
Journal ArticleDOI

The FLASH effect depends on oxygen concentration.

Gabriel Adrian, +5 more
- 01 Feb 2020 - 
TL;DR: In vitro-evidence for the role of oxygen concentration underlying the difference between FLASH and CONV irradiation is shown, and the in vitro FLASH effect depends on oxygen concentration.
References
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Journal ArticleDOI

The novel object recognition memory: neurobiology, test procedure, and its modifications.

Marta Coelho Antunes, +2 more
- 01 May 2012 - 
TL;DR: The neurobiology and methodological modifications of the test commonly used in behavioral pharmacology are reviewed to review the novel object recognition paradigms in animals, as a valuable measure of cognition.
Journal ArticleDOI

AAPM's TG-51 protocol for clinical reference dosimetry of high-energy photon and electron beams.

P. R. Almond, +6 more
- 01 Sep 1999 - 
TL;DR: This protocol represents a major simplification compared to the AAPM's TG-21 protocol in the sense that large tables of stopping-power ratios and mass-energy absorption coefficients are not needed and the user does not need to calculate any theoretical dosimetry factors.
Journal ArticleDOI

Neuroinflammation and M2 microglia: the good, the bad, and the inflamed.

Jonathan D. Cherry, +2 more
- 03 Jun 2014 - 
TL;DR: The multiple possible activation states microglia can be polarized to are examined and particular attention is given to utilizing M2 microglial polarization as a potential therapeutic option in treating diseases.
Journal ArticleDOI

Ultrahigh dose-rate FLASH irradiation increases the differential response between normal and tumor tissue in mice

Vincent Favaudon, +22 more
- 16 Jul 2014 - 
TL;DR: The results suggest that FLASH radiation may be a viable option for treating lung tumors and reduce the occurrence and severity of early and late complications affecting normal tissue.
Journal ArticleDOI

Radiation-induced impairment of hippocampal neurogenesis is associated with cognitive deficits in young mice

Radoslaw Rola, +6 more
- 01 Aug 2004 - 
TL;DR: Evidence is provided that irradiation of young animals induces a long-term impairment of dentate subgranular zone neurogenesis that is associated with hippocampal-dependent memory deficits.
Related Papers (5)

Ultrahigh dose-rate FLASH irradiation increases the differential response between normal and tumor tissue in mice

Vincent Favaudon, +22 more
- 16 Jul 2014 - 

The Advantage of FLASH Radiotherapy Confirmed in Mini-pig and Cat-cancer Patients.

Marie-Catherine Vozenin, +15 more
- 01 Jan 2019 - 

Long-term neurocognitive benefits of FLASH radiotherapy driven by reduced reactive oxygen species.

Pierre Montay-Gruel, +21 more
- 28 May 2019 - 

Treatment of a first patient with FLASH-radiotherapy.

Jean Bourhis, +11 more
- 01 Oct 2019 - 

X-rays can trigger the FLASH effect: Ultra-high dose-rate synchrotron light source prevents normal brain injury after whole brain irradiation in mice.

Pierre Montay-Gruel, +11 more
- 31 Aug 2018 -