Open Access
Mechanisms and models of somatic cell reprogramming
TLDR
Whitehead Institute for Biomedical Research (Jerome and Florence Brill Graduate Student Fellowship) as discussed by the authors ) was the first recipient of the WBIR grant. But this work was performed in a supervised setting.Abstract:
Whitehead Institute for Biomedical Research (Jerome and Florence Brill Graduate Student Fellowship)read more
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Transcriptional Addiction in Cancer
TL;DR: How transcriptional control is disrupted by genetic alterations in cancer cells, why transcriptional dependencies can develop as a consequence of dysregulated programs, and how these dependencies provide opportunities for novel therapeutic interventions in cancer are discussed.
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A decade of transcription factor-mediated reprogramming to pluripotency
TL;DR: The mechanisms underlying transcription factor-mediated reprogramming are still poorly understood; however, several mechanistic insights have recently been obtained, making it more amenable to applications in the fields of regenerative medicine, disease modelling and drug discovery.
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Pioneer transcription factors target partial DNA motifs on nucleosomes to initiate reprogramming
Abdenour Soufi,Meilin Fernandez Garcia,Artur Jaroszewicz,Nebiyu Osman,Matteo Pellegrini,Kenneth S. Zaret +5 more
TL;DR: This work compares the nucleosome and chromatin targeting activities of Oct4, Sox2, and Klf4, which together reprogram somatic cells to pluripotency and provides insight into how pioneer factors can target naive chromatin sites.
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In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming
Alejandro Ocampo,Pradeep Reddy,Paloma Martinez-Redondo,Aida Platero-Luengo,Fumiyuki Hatanaka,Tomoaki Hishida,Mo Li,David Lam,Masakazu Kurita,Masakazu Kurita,Ergin Beyret,Toshikazu Araoka,Toshikazu Araoka,Eric Vazquez-Ferrer,David Donoso,Jose Luis Roman,Jinna Xu,Concepcion Rodriguez Esteban,Gabriel Núñez,Estrella Nuñez Delicado,Josep M. Campistol,Isabel Guillen,Pedro Guillen,Juan Carlos Izpisua Belmonte +23 more
TL;DR: It is reported that partial reprogramming by short-term cyclic expression of Oct4, Sox2, Klf4, and c-Myc (OSKM) ameliorates cellular and physiological hallmarks of aging and prolongs lifespan in a mouse model of premature aging.
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Transcription factors as readers and effectors of DNA methylation
Heng Zhu,Guohua Wang,Jiang Qian +2 more
TL;DR: Evidence is emerging to suggest that transcription factors lacking a MBD can also interact with methylated DNA, and the identification of these proteins and the elucidation of their characteristics and the biological consequences are important stepping stones towards a mechanistic understanding of methylation-mediated biological processes.
References
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Incomplete DNA methylation underlies a transcriptional memory of somatic cells in human iPS cells
Yuki Ohi,Han Qin,Chibo Hong,Laure Blouin,Jose M. Polo,Jose M. Polo,Tingxia Guo,Zhongxia Qi,Sara L. Downey,Philip D. Manos,Philip D. Manos,Derrick J. Rossi,Derrick J. Rossi,Jingwei Yu,Matthias Hebrok,Konrad Hochedlinger,Konrad Hochedlinger,Joseph F. Costello,Jun S. Song,Miguel Ramalho-Santos +19 more
TL;DR: In this article, a systematic comparison of human induced pluripotent stem (iPS) cells generated from hepatocytes (representative of endoderm), skin fibroblasts (mesoderm) and melanocytes (ectoderm).
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Wdr5 Mediates Self-Renewal and Reprogramming via the Embryonic Stem Cell Core Transcriptional Network
Yen-Sin Ang,Su-Yi Tsai,Dung Fang Lee,Jonathan M. Monk,Jie Su,Kajan Ratnakumar,Junjun Ding,Yongchao Ge,Henia Darr,Betty Chang,Jianlong Wang,Michael Rendl,Emily Bernstein,Christoph Schaniel,Ihor R. Lemischka +14 more
TL;DR: It is shown that WD repeat domain 5 (Wdr5), a core member of the mammalian Trithorax (trxG) complex, positively correlates with the undifferentiated state and is a regulator of ES cell self-renewal.
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Elite and stochastic models for induced pluripotent stem cell generation
TL;DR: Why for bottlenecks in induced pluripotent stem cell generation is considered, and a model in which most or all cells have the potential to become pluripotency is proposed.
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Directed transdifferentiation of mouse mesoderm to heart tissue by defined factors.
TL;DR: It is shown that two cardiac transcription factors, Gata4 and Tbx5, and a cardiac-specific subunit of BAF chromatin-remodelling complexes, Baf60c, can direct ectopic differentiation of mouse mesoderm into beating cardiomyocytes, including the normally non-cardiogenic posterior Mesoderm and the extraembryonic mesod Germ of the amnion.
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Genome-wide Chromatin State Transitions Associated with Developmental and Environmental Cues
Jiang Zhu,Mazhar Adli,James Zou,Griet Verstappen,Griet Verstappen,Michael Coyne,Xiaolan Zhang,Timothy Durham,Mohammad Miri,Vikram Deshpande,Philip L. De Jager,Philip L. De Jager,David A. Bennett,Joseph A. Houmard,Deborah M. Muoio,Tamer T. Onder,Raymond Camahort,Raymond Camahort,Chad A. Cowan,Chad A. Cowan,Alexander Meissner,Alexander Meissner,Charles B. Epstein,Noam Shoresh,Bradley E. Bernstein +24 more
TL;DR: The chromatin genome-wide in a large and diverse collection of human tissues and stem cells is mapped to yield unprecedented annotations of functional genomic elements and their regulation across developmental stages, lineages, and cellular environments.