Journal ArticleDOI
Novel sterol glucosyltransferase in the animal tissue and cultured cells: evidence that glucosylceramide as glucose donor.
Hisako Akiyama,Narie Sasaki,Shuwa Hanazawa,Shuwa Hanazawa,Mari Gotoh,Susumu Kobayashi,Yoshio Hirabayashi,Kimiko Murakami-Murofushi +7 more
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TLDR
Results suggest that animal sterol glucosyltransferase transfers glucose moiety from GlcCer to cholesterol, the most effective substrate for CG formation in animal tissues and cultured cells.About:
This article is published in Biochimica et Biophysica Acta.The article was published on 2011-05-01. It has received 18 citations till now. The article focuses on the topics: Heat shock & Uridine diphosphate glucose.read more
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Plasma membranes as heat stress sensors: From lipid-controlled molecular switches to therapeutic applications☆ , ☆☆
Zsolt Török,Tim Crul,Bruno Maresca,Gerhard J. Schütz,Félix Viana,Laura Dindia,Stefano Piotto,Mario Brameshuber,Gábor Balogh,Mária Péter,Amalia Porta,Alfonso Trapani,Imre Gombos,Attila Glatz,Burcin Gungor,Begüm Peksel,László Vígh,Bálint Csoboz,Ibolya Horváth,Mathilakath M. Vijayan,Phillip L. Hooper,John L. Harwood +21 more
TL;DR: The classic heat shock (stress) response (HSR) was originally attributed to protein denaturation, but it is observed that a deregulated HSR is found in a large number of important diseases where more detailed knowledge of the molecular mechanisms involved may offer timely opportunities for clinical interventions and new, innovative drug treatments.
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New insights on glucosylated lipids: Metabolism and functions
TL;DR: The biological functions and metabolism of these three glucosylated lipids, ceramide, cholesterol, and phosphatidic acid, are discussed.
Journal ArticleDOI
Heat Shock Proteins and Autophagy Pathways in Neuroprotection: from Molecular Bases to Pharmacological Interventions
TL;DR: Specific mechanisms that maintain proteostasis are summarized, including molecular chaperons, the ubiquitin-proteasome system (UPS), endoplasmic reticulum associated degradation (ERAD), and different autophagic pathways (chaperon mediated-, micro-, and macro-autophagy).
Journal ArticleDOI
Glucosylated cholesterol in mammalian cells and tissues: formation and degradation by multiple cellular β-glucosidases
André Marques,Mina Mirzaian,Hisako Akiyama,Patrick Wisse,Maria J. Ferraz,Paulo Gaspar,Karen Ghauharali-van der Vlugt,Rianne Meijer,Pilar Giraldo,Pilar Alfonso,Pilar Irún,Maria Dahl,Stefan Karlsson,Elena Pavlova,Timothy M. Cox,Saskia Scheij,Marri Verhoek,Roelof Ottenhoff,Cindy P. A. A. van Roomen,Navraj S. Pannu,Marco van Eijk,Nick Dekker,Rolf G. Boot,Herman S. Overkleeft,E. F. C. Blommaart,Yoshio Hirabayashi,Johannes M. F. G. Aerts +26 more
TL;DR: It is demonstrated that through transglucosylation both GBA and GBA2 are able to catalyze in vitro the transfer of glucosyl-moieties from GlcCer to cholesterol, and vice versa.
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Parkinson's disease: acid‐glucocerebrosidase activity and alpha‐synuclein clearance
Judith Blanz,Paul Saftig +1 more
TL;DR: Therapeutic strategies aiming to increase either the expression, stability or delivery of the β‐glucocerebrosidase to lysosomes are likely to decrease the α‐synuclein burden and may be useful for an in depth evaluation at the organismal level.
References
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A simple method for the isolation and purification of total lipides from animal tissues.
TL;DR: In this paper, the authors described a simplified version of the method and reported the results of a study of its application to different tissues, including the efficiency of the washing procedure in terms of the removal from tissue lipides of some non-lipide substances of special biochemical interest.
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A rapid method of total lipid extraction and purification.
E. G. Bligh,W. J. Dyer +1 more
TL;DR: The lipid decomposition studies in frozen fish have led to the development of a simple and rapid method for the extraction and purification of lipids from biological materials that has been applied to fish muscle and may easily be adapted to use with other tissues.
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Functional rafts in cell membranes
Kai Simons,Elina Ikonen +1 more
TL;DR: A new aspect of cell membrane structure is presented, based on the dynamic clustering of sphingolipids and cholesterol to form rafts that move within the fluid bilayer that function as platforms for the attachment of proteins when membranes are moved around inside the cell and during signal transduction.
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Structure and function of sphingolipid- and cholesterol-rich membrane rafts.
Deborah A. Brown,Erwin London +1 more
TL;DR: This work will review the evidence that rafts exist in cells and focus on their structure, or the organization of raft lipids and proteins, and the role of rafts in signaling in hematopoietic cells.