Sarcopenia: Revised European consensus on definition and diagnosis
Alfonso J. Cruz-Jentoft,Gulistan Bahat,Jürgen M. Bauer,Yves Boirie,Olivier Bruyère,Tommy Cederholm,Cyrus Cooper,Francesco Landi,Yves Rolland,Avan Aihie Sayer,Stéphane M. Schneider,Cornel C. Sieber,Eva Topinkova,Maurits Vandewoude,Marjolein Visser,Mauro Zamboni +15 more
TLDR
An emphasis is placed on low muscle strength as a key characteristic of sarcopenia, uses detection of low muscle quantity and quality to confirm the sarc Openia diagnosis, and provides clear cut-off points for measurements of variables that identify and characterise sarc openia.Abstract:
Background in 2010, the European Working Group on Sarcopenia in Older People (EWGSOP) published a sarcopenia definition that aimed to foster advances in identifying and caring for people with sarcopenia. In early 2018, the Working Group met again (EWGSOP2) to update the original definition in order to reflect scientific and clinical evidence that has built over the last decade. This paper presents our updated findings. Objectives to increase consistency of research design, clinical diagnoses and ultimately, care for people with sarcopenia. Recommendations sarcopenia is a muscle disease (muscle failure) rooted in adverse muscle changes that accrue across a lifetime; sarcopenia is common among adults of older age but can also occur earlier in life. In this updated consensus paper on sarcopenia, EWGSOP2: (1) focuses on low muscle strength as a key characteristic of sarcopenia, uses detection of low muscle quantity and quality to confirm the sarcopenia diagnosis, and identifies poor physical performance as indicative of severe sarcopenia; (2) updates the clinical algorithm that can be used for sarcopenia case-finding, diagnosis and confirmation, and severity determination and (3) provides clear cut-off points for measurements of variables that identify and characterise sarcopenia. Conclusions EWGSOP2's updated recommendations aim to increase awareness of sarcopenia and its risk. With these new recommendations, EWGSOP2 calls for healthcare professionals who treat patients at risk for sarcopenia to take actions that will promote early detection and treatment. We also encourage more research in the field of sarcopenia in order to prevent or delay adverse health outcomes that incur a heavy burden for patients and healthcare systems.read more
Citations
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Journal ArticleDOI
Expression Patterns of Muscle-Specific miR-133b and miR-206 Correlate with Nutritional Status and Sarcopenia
Francesca Iannone,Alberto Montesanto,Erika Cione,Paolina Crocco,Maria Cristina Caroleo,Serena Dato,Giuseppina Rose,Giuseppe Passarino +7 more
TL;DR: A nutrient-miR-133b/ miR-206 pathway having a potential role in the age-related muscle decline is highlighted, suggesting a mediating effect of nutrition on the relationship between miR -133b and sarcopenia.
Journal ArticleDOI
Machine Learning for Automatic Paraspinous Muscle Area and Attenuation Measures on Low-Dose Chest CT Scans.
Ryan T. Barnard,Josh Tan,Brandon L. Roller,Caroline Chiles,Ashley A. Weaver,Robert D. Boutin,Stephen B. Kritchevsky,Leon Lenchik +7 more
TL;DR: The ML algorithm for measurement of paraspinous muscles compared favorably to manual ground truth measurements in the NLST and may be capable of automated quantification of muscle metrics to screen for sarcopenia on routine chest CT examinations.
Journal ArticleDOI
German Version of SARC-F: Translation, Adaption, and Validation.
Michael Drey,Uta Ferrari,Marina Schraml,Wolfgang Kemmler,Daniel Schoene,Anna Franke,Ellen Freiberger,Robert Kob,Cornel C. Sieber +8 more
TL;DR: The translated and culturally adapted version of the SARC-F for the German language has shown excellent inter-rater reliability and good test-retest reliability and the internal consistency is acceptable.
Journal ArticleDOI
Awareness, perceptions and practices regarding cancer-related malnutrition and sarcopenia: a survey of cancer clinicians
Nicole Kiss,Nicole Kiss,Judy Bauer,Anna Boltong,Teresa Brown,Teresa Brown,Liz Isenring,Liz Isenring,Jenelle Loeliger,Belinda Steer,Merran Findlay +10 more
TL;DR: While awareness of the importance of cancer-related malnutrition and sarcopenia are high, participants identified substantial barriers to delivering optimal nutrition care.
Journal ArticleDOI
Biomarkers of sarcopenia in very old patients with hip fracture
C. Sánchez-Castellano,Sagrario Martín-Aragón,Paloma Bermejo-Bescós,Nieves Vaquero-Pinto,Carmen Miret-Corchado,Ana Merello de Miguel,Alfonso J. Cruz-Jentoft +6 more
TL;DR: Potential biomarkers (neuromuscular and peripheral pro‐inflammatory and oxidative stress markers) that may be associated with sarcopenia in very old persons with hip fracture are explored.
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