Sarcopenia: Revised European consensus on definition and diagnosis
Alfonso J. Cruz-Jentoft,Gulistan Bahat,Jürgen M. Bauer,Yves Boirie,Olivier Bruyère,Tommy Cederholm,Cyrus Cooper,Francesco Landi,Yves Rolland,Avan Aihie Sayer,Stéphane M. Schneider,Cornel C. Sieber,Eva Topinkova,Maurits Vandewoude,Marjolein Visser,Mauro Zamboni +15 more
TLDR
An emphasis is placed on low muscle strength as a key characteristic of sarcopenia, uses detection of low muscle quantity and quality to confirm the sarc Openia diagnosis, and provides clear cut-off points for measurements of variables that identify and characterise sarc openia.Abstract:
Background in 2010, the European Working Group on Sarcopenia in Older People (EWGSOP) published a sarcopenia definition that aimed to foster advances in identifying and caring for people with sarcopenia. In early 2018, the Working Group met again (EWGSOP2) to update the original definition in order to reflect scientific and clinical evidence that has built over the last decade. This paper presents our updated findings. Objectives to increase consistency of research design, clinical diagnoses and ultimately, care for people with sarcopenia. Recommendations sarcopenia is a muscle disease (muscle failure) rooted in adverse muscle changes that accrue across a lifetime; sarcopenia is common among adults of older age but can also occur earlier in life. In this updated consensus paper on sarcopenia, EWGSOP2: (1) focuses on low muscle strength as a key characteristic of sarcopenia, uses detection of low muscle quantity and quality to confirm the sarcopenia diagnosis, and identifies poor physical performance as indicative of severe sarcopenia; (2) updates the clinical algorithm that can be used for sarcopenia case-finding, diagnosis and confirmation, and severity determination and (3) provides clear cut-off points for measurements of variables that identify and characterise sarcopenia. Conclusions EWGSOP2's updated recommendations aim to increase awareness of sarcopenia and its risk. With these new recommendations, EWGSOP2 calls for healthcare professionals who treat patients at risk for sarcopenia to take actions that will promote early detection and treatment. We also encourage more research in the field of sarcopenia in order to prevent or delay adverse health outcomes that incur a heavy burden for patients and healthcare systems.read more
Citations
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AChRs Degeneration at NMJ in Aging-Associated Sarcopenia-A Systematic Review.
TL;DR: Investigating the role of these AChRs-related genes in the process of aging may provide a potential target to treat sarcopenia.
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Decline in Muscle Strength and Performance Predicts Fracture Risk in Elderly Women and Men.
Dima Alajlouni,Dima Alajlouni,Dana Bliuc,Dana Bliuc,Thach Tran,Thach Tran,John A. Eisman,John A. Eisman,John A. Eisman,Tuan V. Nguyen,Tuan V. Nguyen,Tuan V. Nguyen +11 more
TL;DR: Rate of decline in physical performance in both genders, and baseline strength and performance in men contributed independently to fracture risk, and 5xSTS and GS were the tests most consistently associated with fractures.
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The Refeeding Syndrome: a neglected but potentially serious condition for inpatients. A narrative review.
TL;DR: The objectives of this narrative review were to summarize the current knowledge and recommendations about the RFS and to provide useful tips to help physicians to recognize and prevent the syndrome.
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The TOR Pathway at the Neuromuscular Junction: More Than a Metabolic Player?
TL;DR: The role of the metabolic pathway associated to the kinase TOR (Target of Rapamycin) in the development, maintenance and alterations of the NMJ is discussed and the respective functions of the two TOR-associated complexes, TORC1 and TORC2, are highlighted.
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Association Between Muscle Quality Measured by Abdominal Computed Tomography and Subclinical Coronary Atherosclerosis.
TL;DR: A higher proportion of good quality muscle was strongly associated with a lower prevalence of significant coronary artery calcification after adjustment, especially in women, and the association was attenuated in Q3-4 after adjustment.
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