Sarcopenia: Revised European consensus on definition and diagnosis
Alfonso J. Cruz-Jentoft,Gulistan Bahat,Jürgen M. Bauer,Yves Boirie,Olivier Bruyère,Tommy Cederholm,Cyrus Cooper,Francesco Landi,Yves Rolland,Avan Aihie Sayer,Stéphane M. Schneider,Cornel C. Sieber,Eva Topinkova,Maurits Vandewoude,Marjolein Visser,Mauro Zamboni +15 more
TLDR
An emphasis is placed on low muscle strength as a key characteristic of sarcopenia, uses detection of low muscle quantity and quality to confirm the sarc Openia diagnosis, and provides clear cut-off points for measurements of variables that identify and characterise sarc openia.Abstract:
Background in 2010, the European Working Group on Sarcopenia in Older People (EWGSOP) published a sarcopenia definition that aimed to foster advances in identifying and caring for people with sarcopenia. In early 2018, the Working Group met again (EWGSOP2) to update the original definition in order to reflect scientific and clinical evidence that has built over the last decade. This paper presents our updated findings. Objectives to increase consistency of research design, clinical diagnoses and ultimately, care for people with sarcopenia. Recommendations sarcopenia is a muscle disease (muscle failure) rooted in adverse muscle changes that accrue across a lifetime; sarcopenia is common among adults of older age but can also occur earlier in life. In this updated consensus paper on sarcopenia, EWGSOP2: (1) focuses on low muscle strength as a key characteristic of sarcopenia, uses detection of low muscle quantity and quality to confirm the sarcopenia diagnosis, and identifies poor physical performance as indicative of severe sarcopenia; (2) updates the clinical algorithm that can be used for sarcopenia case-finding, diagnosis and confirmation, and severity determination and (3) provides clear cut-off points for measurements of variables that identify and characterise sarcopenia. Conclusions EWGSOP2's updated recommendations aim to increase awareness of sarcopenia and its risk. With these new recommendations, EWGSOP2 calls for healthcare professionals who treat patients at risk for sarcopenia to take actions that will promote early detection and treatment. We also encourage more research in the field of sarcopenia in order to prevent or delay adverse health outcomes that incur a heavy burden for patients and healthcare systems.read more
Citations
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Muscle Mass Loss in the Older Critically Ill Population: Potential Therapeutic Strategies.
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Skeletal Muscle Dysfunction in the Development and Progression of Nonalcoholic Fatty Liver Disease.
TL;DR: The relationship between skeletal muscle and liver in various stages of NAFLD progression is reviewed and current knowledge of the pathophysiology is summarized with the goal of better understanding the natural history, risk stratification, and management ofNAFLD.
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Whey for Sarcopenia; Can Whey Peptides, Hydrolysates or Proteins Play a Beneficial Role?
TL;DR: The evidence that whey protein, hydrolysates or peptides may have beneficial effects on sarcopenic biomarkers in myoblast cell lines, in aged rodents and in human dietary intervention trials with the older consumer is explored.
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A Review of Sarcopenia Pathophysiology, Diagnosis, Treatment and Future Direction
TL;DR: Future research should focus on sarcopenia biological pathway and improved diagnostic approaches such as biomarkers for early detection, development of consistently pre-eminent treatment methods for severe sarc Openia patients, and establishing sensitive measures for predicting sarcopenian treatment response.
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Reduced muscle mass as predictor of intensive care unit hospitalization in COVID-19 patients.
Chiara Giraudo,Giovanni Librizzi,Giulia Fichera,Raffaella Motta,Elisabetta Balestro,Fiorella Calabrese,Giovanni Carretta,Anna Maria Cattelan,Paolo Navalesi,Michela Pelloso,Mario Plebani,Federico Rea,Roberto Vettor,Andrea Vianello,Roberto Stramare +14 more
TL;DR: In this article, the authors evaluated if reduced muscle mass, assessed with computed tomography (CT), is a predictor of intensive care unit (ICU) hospitalization in COVID-19 patients.
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