Sarcopenia: Revised European consensus on definition and diagnosis
Alfonso J. Cruz-Jentoft,Gulistan Bahat,Jürgen M. Bauer,Yves Boirie,Olivier Bruyère,Tommy Cederholm,Cyrus Cooper,Francesco Landi,Yves Rolland,Avan Aihie Sayer,Stéphane M. Schneider,Cornel C. Sieber,Eva Topinkova,Maurits Vandewoude,Marjolein Visser,Mauro Zamboni +15 more
TLDR
An emphasis is placed on low muscle strength as a key characteristic of sarcopenia, uses detection of low muscle quantity and quality to confirm the sarc Openia diagnosis, and provides clear cut-off points for measurements of variables that identify and characterise sarc openia.Abstract:
Background in 2010, the European Working Group on Sarcopenia in Older People (EWGSOP) published a sarcopenia definition that aimed to foster advances in identifying and caring for people with sarcopenia. In early 2018, the Working Group met again (EWGSOP2) to update the original definition in order to reflect scientific and clinical evidence that has built over the last decade. This paper presents our updated findings. Objectives to increase consistency of research design, clinical diagnoses and ultimately, care for people with sarcopenia. Recommendations sarcopenia is a muscle disease (muscle failure) rooted in adverse muscle changes that accrue across a lifetime; sarcopenia is common among adults of older age but can also occur earlier in life. In this updated consensus paper on sarcopenia, EWGSOP2: (1) focuses on low muscle strength as a key characteristic of sarcopenia, uses detection of low muscle quantity and quality to confirm the sarcopenia diagnosis, and identifies poor physical performance as indicative of severe sarcopenia; (2) updates the clinical algorithm that can be used for sarcopenia case-finding, diagnosis and confirmation, and severity determination and (3) provides clear cut-off points for measurements of variables that identify and characterise sarcopenia. Conclusions EWGSOP2's updated recommendations aim to increase awareness of sarcopenia and its risk. With these new recommendations, EWGSOP2 calls for healthcare professionals who treat patients at risk for sarcopenia to take actions that will promote early detection and treatment. We also encourage more research in the field of sarcopenia in order to prevent or delay adverse health outcomes that incur a heavy burden for patients and healthcare systems.read more
Citations
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Sarcopenic Obesity in Liver Cirrhosis: Possible Mechanism and Clinical Impact
TL;DR: In this paper, the authors overview the current knowledge of sarcopenic obesity (Sa-O), especially focusing on liver cirrhosis, and discuss the pathogenesis of Sa-O in chronic liver diseases.
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A Comparison of Different Frailty Scores and Impact of Frailty on Outcome in Patients With Cirrhosis
Sunil Taneja,Surender Singh,Sunil Taneja,Puneeta Tandon,Akash Bansal,Ujjwal Gorsi,Akash Roy,Arka De,Nipun Verma,Madhumita Premkumar,Ajay Duseja,Radha K. Dhiman,Virendra Singh +12 more
TL;DR: LFI, SPPB, FFC, and CFS are comparable in frailty assessment in patients with cirrhosis and comparison allows flexibility for clinical application.
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Lower grip strength and dynamic body balance in women with distal radial fractures
Koji Fujita,Hidetoshi Kaburagi,Akimoto Nimura,Takashi Miyamoto,Yoshiaki Wakabayashi,Y. Seki,H. Aoyama,Haruhiko Shimura,R. Kato,Atsushi Okawa +9 more
TL;DR: It was concluded that women with distal radial fractures who were surgically treated showed lower grip strength and dynamic body balancing than those of controls, suggesting that measurements of grip strengthand dynamic body balance may be useful screening tools to assess future fracture risk.
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Update of the European consensus on sarcopenia: what has changed in diagnosis and prevalence in peritoneal dialysis?
Maryanne Zilli Canedo Silva,Barbara Perez Vogt,Nayrana Soares do Carmo Reis,Jacqueline Costa Teixeira Caramori +3 more
TL;DR: An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Advances in the Role of Leucine-Sensing in the Regulation of Protein Synthesis in Aging Skeletal Muscle.
Yan Zhao,Jason Cholewa,Hua-Yu Shang,Yue-Qin Yang,Xiaomin Ding,Qianjin Wang,Quan-Sheng Su,Nelo Eidy Zanchi,Zhi Xia,Zhi Xia +9 more
TL;DR: In this paper, the authors systematically summarized the three critical processes involved in the leucine-sensing and response process: (1) How the coincidence detector mammalian target of rapamycin complex 1 localizes on the surface of lysosome and how its crucial upstream regulators Rheb and RagB/RagD interact to modulate the leuceine response; (2) how complexes such as Ragulator, GATOR, FLCN, and TSC control the nucleotide loading state of RHEb and RB/RB/RB, and (3
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Alfonso J. Cruz-Jentoft,Jean-Pierre Baeyens,Jürgen M. Bauer,Yves Boirie,Tommy Cederholm,Francesco Landi,Finbarr C. Martin,Jean-Pierre Michel,Yves Rolland,Stéphane M. Schneider,Eva Topinkova,Maurits Vandewoude,Mauro Zamboni +12 more
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