Sarcopenia: Revised European consensus on definition and diagnosis
Alfonso J. Cruz-Jentoft,Gulistan Bahat,Jürgen M. Bauer,Yves Boirie,Olivier Bruyère,Tommy Cederholm,Cyrus Cooper,Francesco Landi,Yves Rolland,Avan Aihie Sayer,Stéphane M. Schneider,Cornel C. Sieber,Eva Topinkova,Maurits Vandewoude,Marjolein Visser,Mauro Zamboni +15 more
TLDR
An emphasis is placed on low muscle strength as a key characteristic of sarcopenia, uses detection of low muscle quantity and quality to confirm the sarc Openia diagnosis, and provides clear cut-off points for measurements of variables that identify and characterise sarc openia.Abstract:
Background in 2010, the European Working Group on Sarcopenia in Older People (EWGSOP) published a sarcopenia definition that aimed to foster advances in identifying and caring for people with sarcopenia. In early 2018, the Working Group met again (EWGSOP2) to update the original definition in order to reflect scientific and clinical evidence that has built over the last decade. This paper presents our updated findings. Objectives to increase consistency of research design, clinical diagnoses and ultimately, care for people with sarcopenia. Recommendations sarcopenia is a muscle disease (muscle failure) rooted in adverse muscle changes that accrue across a lifetime; sarcopenia is common among adults of older age but can also occur earlier in life. In this updated consensus paper on sarcopenia, EWGSOP2: (1) focuses on low muscle strength as a key characteristic of sarcopenia, uses detection of low muscle quantity and quality to confirm the sarcopenia diagnosis, and identifies poor physical performance as indicative of severe sarcopenia; (2) updates the clinical algorithm that can be used for sarcopenia case-finding, diagnosis and confirmation, and severity determination and (3) provides clear cut-off points for measurements of variables that identify and characterise sarcopenia. Conclusions EWGSOP2's updated recommendations aim to increase awareness of sarcopenia and its risk. With these new recommendations, EWGSOP2 calls for healthcare professionals who treat patients at risk for sarcopenia to take actions that will promote early detection and treatment. We also encourage more research in the field of sarcopenia in order to prevent or delay adverse health outcomes that incur a heavy burden for patients and healthcare systems.read more
Citations
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Low thoracic skeletal muscle area is not associated with negative outcomes in patients with COVID-19.
Paulina Moctezuma-Velázquez,Godolfino Miranda-Zazueta,Edgar Ortiz-Brizuela,María F González-Lara,Karla M Tamez-Torres,Carla M Roman-Montes,Bruno A. Díaz-Mejía,Esteban Pérez-García,Marco Villanueva-Reza,Víctor Hugo Tovar-Méndez,Carla Medrano-Borromeo,Alejandra Martínez-Valenzuela,Míguel Ángel Jandete-Medina,Bernardo A Martinez-Guerra,L.F. Uscanga-Domínguez,José Sifuentes-Osornio,Alfredo Ponce-de-León,Antonio Olivas-Martinez,Carlos Moctezuma-Velázquez +18 more
TL;DR: In this article, the skeletal muscle index determined by computed tomography at the level of twelfth thoracic vertebra was not associated with negative outcomes in hospitalized patients with COVID-19.
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Subchronic exposure to cellulose nanofibrils induces nutritional risk by non-specifically reducing the intestinal absorption.
TL;DR: The results demonstrated that CNF decreased fat absorption in the jejunum and attenuated WD-induced fatty liver, but slightly decreased lean body mass and affected glucose homeostasis.
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Dysregulations of mitochondrial quality control and autophagic flux at an early age lead to progression of sarcopenia in SAMP8 mice
TL;DR: The data suggest that early alterations of mitochondrial quality control and autophagic flux worsen muscle microenvironment prior to the onset of sarcopenia in SAMP8 mice.
Journal ArticleDOI
Lower Dietary and Circulating Vitamin C in Middle- and Older-Aged Men and Women Are Associated with Lower Estimated Skeletal Muscle Mass.
Lucy N Lewis,Richard P. G. Hayhoe,Angela A. Mulligan,Robert Luben,Kay-Tee Khaw,Ailsa A Welch +5 more
TL;DR: Positive associations, of both dietary and circulating vitamin C with measures of skeletal muscle mass in middle- and older-aged men and women, suggest that dietary vitamin C intake may be useful for reducing age-related muscle loss.
Journal ArticleDOI
High prevalence and clinical impact of dynapenia and sarcopenia in Japanese patients with type 1 and type 2 diabetes: Findings from the Impact of Diabetes Mellitus on Dynapenia study.
Hiroyasu Mori,Akio Kuroda,Sumiko Yoshida,Tetsuyuki Yasuda,Yutaka Umayahara,Sayoko Shimizu,Kayoko Ryomoto,Kazutomi Yoshiuchi,Tsunehiko Yamamoto,Taka-aki Matsuoka,Iichiro Shimomura,Munehide Matsuhisa +11 more
TL;DR: The present study aimed to clarify the prevalence and clinical characteristics of sarcopenia and dynapenia, which are muscle weakness with and without low muscle mass, respectively, in Japanese patients with type 1 Diabetes mellitus and type 2 diabetes mellitus.
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